Jujing Formula Protects Retinal by Regulating Nrf2/Ho-1 Pathways and Sphingolipid Rheostat and its Key Protein Levels on Liver-Kidney Yin Deficient Retinal Damage Mice
Опубликована: Янв. 1, 2025
Язык: Английский
Multi-omics Mendelian Randomization Reveals Immunometabolic Signatures of the Gut Microbiota in Optic Neuritis and the Potential Therapeutic Role of Vitamin B6
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Optic
neuritis
(ON)
is
an
inflammatory
condition
often
linked
to
autoimmune
disorders
like
multiple
sclerosis
(MS)
and
neuromyelitis
optica
spectrum
disorder
(NMOSD).
Despite
its
low
incidence,
ON
can
lead
severe,
irreversible
visual
impairment.
Emerging
evidence
suggests
the
gut
microbiota
(GM)
may
influence
through
complex
immune
metabolic
pathways,
yet
mechanisms
remain
underexplored.
This
study
employed
a
multi-omics
Mendelian
randomization
(MR)
approach
assess
causal
relationships
between
GM
taxa
ON.
We
analyzed
data
from
extensive
genetic
profiling,
examining
effect
473
taxa,
731
cells/traits,
1400
metabolites,
vitamin
B6,
Our
methodology
involved
two-sample
MR
analysis
establish
causality
mediation
explore
potential
therapeutic
strategies.
identified
27
with
direct
relationship
risk.
Further
highlighted
three
particularly
strong
associations.
Mediation
revealed
specific
pathways
which
these
exert
their
effects,
including
notable
interactions
B6
metabolism,
appeared
mediate
some
of
relationships.
found
that
could
be
method
by
acting
on
in
advances
our
understanding
etiology
highlights
as
target
for
The
significant
role
new
avenues
prevention
treatment,
emphasizing
need
further
research
into
diet-based
interventions.
Язык: Английский
Pharmacokinetic profiling and network pharmacology of honey-fried Licorice: An Integrative workflow to study traditional Chinese medicines (TCMs)
Journal of Chromatography B,
Год журнала:
2024,
Номер
1248, С. 124353 - 124353
Опубликована: Ноя. 1, 2024
Язык: Английский
Potential application of traditional Chinese medicine in age-related macular degeneration—focusing on mitophagy
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 17, 2024
Retinal
pigment
epithelial
cell
and
neuroretinal
damage
in
age-related
macular
degeneration
(AMD)
can
lead
to
serious
visual
impairments
blindness.
Studies
have
shown
that
mitophagy,
a
highly
specialized
cellular
degradation
system,
is
implicated
the
pathogenesis
of
AMD.
Mitophagy
selectively
eliminates
impaired
or
non-functioning
mitochondria
via
several
pathways,
such
as
phosphatase
tensin
homolog-induced
kinase
1/Parkin,
BCL2-interacting
protein
3
NIP3-like
X,
FUN14
domain-containing
1,
AMP-activated
pathways.
This
has
major
impact
on
maintenance
mitochondrial
homeostasis.
Therefore,
regulation
mitophagy
could
be
promising
therapeutic
strategy
for
Traditional
Chinese
medicine
(TCM)
uses
natural
products
potentially
prevent
treat
various
diseases,
review
aims
summarize
recent
findings
pathways
latest
progress
AMD
treatment
targeting
emphasizing
methods
involving
TCM.
Язык: Английский