Atractylodin alleviates polycystic ovary syndrome by inhibiting granule cells ferroptosis through pyruvate dehydrogenase kinase 4-mediated JAK-STAT3 pathway DOI
Qi Zhou,

Xuenong Ouyang,

Hong Tang

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 146, С. 113817 - 113817

Опубликована: Дек. 25, 2024

Язык: Английский

Mechanism and Molecular Targets of Euphorbia fischeriana Steud Root Extract in Hepatocellular Carcinoma DOI
Xinchen Tian,

Fen Liu,

Jing Zhao

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119707 - 119707

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Decoding the power of saponins in ferroptosis regulation and disease intervention: a review DOI
Min Ouyang, Jianhua Wu, Xizhuo Hu

и другие.

Journal of Pharmacy and Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 30, 2024

Abstract Objectives This review endeavors to elucidate the complex interplay underlying diseases associated with ferroptosis and delineate multifaceted mechanisms by which triterpenoid steroidal saponins modulate this form of cell death. Methods A meticulous examination literature was undertaken, drawing from an array databases including Web Science, PubMed, Wiley Library, a focus on keywords “ferroptosis,” “saponin,” “cancer,” “inflammation,” “natural products,” “signaling pathways.” Key findings Ferroptosis represents distinctive mode death that holds considerable promise for development innovative therapeutic strategies targeting wide range diseases, especially cancer inflammatory disorders. reveals nuanced interactions between critical signaling pathways, system Xc−-GSH-GPX4, Nrf2, p53, mTOR. These highlight dual capacity ferroptosis, thereby offering fresh perspectives intervention. Conclusions The insights garnered significantly advance our comprehension dynamic relationship ferroptosis. By shedding light these mechanisms, work sets stage leveraging in creation pioneering approaches disease treatment, marking significant stride evolution modalities.

Язык: Английский

Процитировано

2
Targeting NFE2L2/GPX4 signaling pathway: Therapeutic potential of arsenic sulfide-induced ferroptosis in combating rhabdomyosarcoma DOI Creative Commons
Yu Cai,

Shumin Lu,

Chuanying Zhu

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113614 - 113614

Опубликована: Ноя. 15, 2024

Язык: Английский

Процитировано

0
Atractylodin alleviates polycystic ovary syndrome by inhibiting granule cells ferroptosis through pyruvate dehydrogenase kinase 4-mediated JAK-STAT3 pathway DOI
Qi Zhou,

Xuenong Ouyang,

Hong Tang

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 146, С. 113817 - 113817

Опубликована: Дек. 25, 2024

Язык: Английский

Процитировано

0