Reactive Oxygen Species-Responsive Pillararene-Embedded Covalent Organic Frameworks with Amplified Antimicrobial Photodynamic Therapy for the Targeted Elimination of Periodontitis Pathogens

Nano Letters, Год журнала: 2024, Номер 24(43), С. 13708 - 13717

Опубликована: Окт. 17, 2024

Reactive oxygen species (ROS)-responsive drug delivery systems possess immense potential for targeted and controlled release of therapeutics. However, the rapid responsiveness to ROS sustained antibacterial drugs are often limited by challenging microenvironment periodontitis. Integrating ROS-responsive with photocatalytic technologies presents a strategic approach overcome these limitations. Herein, pillararene-embedded covalent organic framework (PCOF) incorporating prodrug thioacetal (TA) has been developed treat This drug-loaded nanoplatform, namely TA-loaded PCOF, utilizes self-amplifying property enhance therapeutic efficacy. PCOFs demonstrate exceptional photosensitivity generation capabilities when employed as carriers. When exposed ROS, TA within nanoplatform was activated cleaved into cinnamaldehyde (CA), highly potent compound. By leveraging visible light activate site-specific infection targeting, PCOF effectively alleviated periodontitis, thereby advancing field systems.

Язык: Английский

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Potential Effect of Cinnamaldehyde on Insulin Resistance Is Mediated by Glucose and Lipid Homeostasis

Nutrients, Год журнала: 2025, Номер 17(2), С. 297 - 297

Опубликована: Янв. 15, 2025

Diabetes mellitus is a metabolic syndrome that has grown globally to become significant public health challenge. Hypothesizing the plasma membrane protein, transient receptor potential ankyrin-1, pivotal target in insulin resistance, we investigated mechanism of action cinnamaldehyde (CIN), an electrophilic TRPA1 agonist, skeletal muscle, primary target. Specifically, evaluated effect CIN on hepatic glycogen accumulation and muscle adipose tissue glucose uptake. Furthermore, vitro role uptake intracellular signaling was determined insulin-resistant rats whose calcium influx analyzed. Moreover, serum lipid profile assessed following short-term treatment rats, tolerance The effects resistance were mediated by TRPA1, with downstream involving activation PI3-K, MAPK, PKC, as well extracellular release from stores. Additionally, cytoskeleton integrity required for complete muscle. also ameliorated improved triglyceride acute vivo exposure.

Язык: Английский

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Unraveling anthelmintic targets and mechanisms of action of trans-cinnamaldehyde from cinnamon essential oil

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 13, 2025

Parasitic nematodes pose a significant global socio-economic threat and contribute to neglected diseases. Current infection control relies on drug therapy, but increasing anthelmintic resistance highlights the urgent need for novel treatments. In this study, we investigate molecular targets mechanisms of action trans-cinnamaldehyde (TCA), principal component Cinnamon Essential Oil (Cinnamomum verum EO), using Caenorhabditis elegans as model organism. Our research offers new insights into effects TCA by identifying its specific interactions with key Cys-loop receptors detailing inhibitory mechanisms. The activity C. EO manifests rapid alterations in locomotor inhibition egg hatching. screening mutant worms lacking reveal multiple receptor targets, including levamisole-sensitive nicotinic ACh (L-AChR), GABA-activated chloride channel (UNC-49) glutamate-activated channel. mechanism behind hatching remains unclear, none mutants studied were found be resistant TCA. Furthermore, increases paralyzing anthelmintics levamisole monepantel synergistic manner, offering route more effective polytherapy strategies. Electrophysiological studies receptors, both native heterologous systems, used elucidate TCA-induced paralysis. reduces ACh- GABA-elicited macroscopic currents decreases single-channel open durations muscle L-AChR channels, indicating an action. Thus, acting through different that classical anthelmintics, may beneficial counteract combined therapies. findings underscore potential multitarget compound valuable tool integrated pharmacological

Язык: Английский

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Cinnamaldehyde Alleviates Salmonellosis in Chicks by Regulating Gut Health

Veterinary Sciences, Год журнала: 2025, Номер 12(3), С. 237 - 237

Опубликована: Март 3, 2025

Due to the high mortality rate in chicks caused by pullorum disease (PD) and drawbacks of antibiotic resistance, poultry industry is increasingly interested using natural herbal antimicrobial agents as alternatives, with cinnamaldehyde (CA) being a focus due its multitarget synergistic effects. This study aimed evaluate effects oral administration CA on restoring intestinal physical integrity, microbial barrier, metabolism laboratory model Salmonella (S. pullorum) infection chicks. Thirty-six were divided into six groups. The S.P groups infected 5 × 108 CFU/mL, 0.5 mL S. pullorum, while CON group received an equal-volume saline injection. was treated 100 mg/kg CA, others phosphate buffer (PBS). Samples collected 24 h after last treatment. Intestinal integrity assessed H&E staining, ELISA used measure inflammatory factors. In situ hybridization (ISH) RT-qPCR expression tight-junction protein mRNA. microbiota analyzed 16S rRNA gene sequencing ileal contents, metabolite analysis performed contents. After treatment, IL-1β TNF-α reduced, IL-10 increased (p < 0.05). staining showed that structure partially restored ISH results fluorescence intensity indicating status low group, reduced permeability. up-regulated mRNA proteins (claudin-1, occludin-1, zo-1, p sequence significantly enriched (LDA score > 2.0, 0.05), specific genera more abundant Untargeted contents key metabolites (butyrate, alanine, glutamate, cholesterol, propionate) changed compared treatment most effective method for reducing PD colonization maintaining better homeostasis, possibly regulating metabolic functions.

Язык: Английский

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The Protective Role of Cinnamaldehyde in Kidney Injury: Modulation of NF-κB and PI3K/Akt Signaling Pathways

Journal for Research in Applied Sciences and Biotechnology, Год журнала: 2025, Номер 4(1), С. 132 - 141

Опубликована: Фев. 28, 2025

Chronic renal disease is defined as the presence of kidney damage or impaired function over a period at least three months, regardless origin condition. Numerous factors, including oxidative stress, inflammation, and cell death, are frequently responsible for acute chronic injury, which significant issue in field global health. Because crucial functions that they play, NF-κB PI3K/Akt signaling pathways potential therapeutic targets. These pathogenic processes mediated by these pathways. cinnamonaldehyde, naturally occurring bioactive component, has demonstrated encouraging nephroprotective properties. properties attributed to fact it contains anti-inflammatory, antioxidant, anti-apoptotic The purpose this review investigate molecular role cinnamaldehyde preventing modulating Within article, we examine involved highlight treatment disease. Although preclinical studies have protective effects, additional research, clinical trials, required validate its safety, effectiveness, uses management illness people.

Язык: Английский

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Sources, bioactivities, and industrial importance of plant-based aroma compounds

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 15 - 24

Опубликована: Янв. 1, 2025

Язык: Английский

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Promoting collagen synthesis: a viable strategy to combat skin ageing

Journal of Enzyme Inhibition and Medicinal Chemistry, Год журнала: 2025, Номер 40(1)

Опубликована: Апрель 11, 2025

Skin ageing is a complex physiological process primarily characterised by the deepening of wrinkles and sagging skin. Collagen essential for maintaining skin elasticity firmness. As ages, it experiences structural functional changes in collagen, including decrease collagen synthesis an increase hydrolysis. Thus, promoting represents practical strategy mitigating ageing. This review systematically described functions, classifications biosynthesis as well its role Additionally, major signalling pathways targets associated with were also discussed. More importantly, provided detailed summary natural products synthesis-promoting effects highlighted small molecule compounds potential anti-ageing activity, especially PPARδ agonists. The relevant content offers lead development anti-skin therapies.

Язык: Английский

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Potential of Cinnamomum zeylanicum for metabolic syndrome management: insights from in vivo and human studies

Journal of Integrative Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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2′-Hydroxycinnamaldehyde, a Natural Product from Cinnamon, Alleviates Ischemia/Reperfusion-Induced Microvascular Dysfunction and Oxidative Damage in Rats by Upregulating Cytosolic BAG3 and Nrf2/HO-1

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12962 - 12962

Опубликована: Дек. 2, 2024

2'-Hydroxycinnamaldehyde (HCA), a natural product isolated from the bark of

Язык: Английский

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Sodium thiosulfate modified graphitic carbon nitride for enhancing the photocatalytic production of aldehydes

Sustainable materials and technologies, Год журнала: 2024, Номер 42, С. e01123 - e01123

Опубликована: Сен. 20, 2024

Язык: Английский

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