Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols
Pharmaceuticals,
Год журнала:
2024,
Номер
17(10), С. 1354 - 1354
Опубликована: Окт. 10, 2024
Metabolic-Associated
Fatty
Liver
Disease
(MAFLD)
is
a
clinical-pathological
scenario
that
occurs
due
to
the
accumulation
of
triglycerides
in
hepatocytes
which
considered
significant
cause
liver
conditions
and
contributes
an
increased
risk
death
worldwide.
Even
though
possible
causes
MAFLD
can
involve
interaction
genetics,
hormones,
nutrition,
lifestyle
(diet
sedentary
lifestyle)
most
influential
factor
developing
this
condition.
Polyphenols
comprise
many
natural
chemical
compounds
be
helpful
managing
metabolic
diseases.
Therefore,
aim
review
was
investigate
impact
oxidative
stress,
inflammation,
mitochondrial
dysfunction,
role
polyphenols
MAFLD.
Some
reverse
part
damage
related
or
among
them
are
anthocyanin,
baicalin,
catechin,
curcumin,
chlorogenic
acid,
didymin,
epigallocatechin-3-gallate,
luteolin,
mangiferin,
puerarin,
punicalagin,
resveratrol,
silymarin.
These
have
actions
reducing
plasma
enzymes,
body
mass
index,
waist
circumference,
adipose
visceral
indices,
lipids,
glycated
hemoglobin,
insulin
resistance,
HOMA
index.
They
also
reduce
nuclear
factor-KB
(NF-KB),
interleukin
(IL)-1β,
IL-6,
tumor
necrosis
factor-α
(TNF-α),
blood
pressure,
fat
content,
steatosis
fibrosis.
On
other
hand,
they
improve
HDL-c,
adiponectin
levels,
fibrogenesis
markers.
results
show
promising
prevention
treatment
Язык: Английский
Bibliometric Web of Science and Google Trends analysis of multi-criteria decision analysis within the built environment
Frontiers in Built Environment,
Год журнала:
2025,
Номер
11
Опубликована: Март 3, 2025
This
research
aims
to
leverage
existing
data
sources
provide
new
insights
into
the
usage
of
Multi-Criteria
Decision
Analysis
(MCDA)
in
built
environment
without
creating
a
collection
process.
The
study
is
focused
upon
vocations,
spanning
disciplines
architecture,
construction
management,
urban
planning,
real
estate,
facilities
and
numerous
engineering
domains
that
support
capital
projects.
method
utilized
Google
search
engine
from
Trends
academic
literature
metadata
Web
Science,
which
was
analyzed
using
Bibliometrix
via
Biblioshiny
interface.
These
datasets
were
cross-referenced
with
original
collected
Qualtrics
delivered
industry
questionnaire
develop
more
comprehensive
understanding
MCDA
adoption
within
environment.
presents
ranked
list
methods
used
vocations
order
level
adoption,
top
five
being
PROMETHEE,
House
Quality,
Monte
Carlo
Simulations,
TOPSIS,
Utility
Theory.
results
include
visualizations
for
studied
papers
findings
related
tool
associations
key
clusters,
such
as
GIS
drone
based
usage,
concert
methods.
paper
evidence
MCDAs
are
frequently
environmental
science,
geography,
sustainability
studies
relative
other
design
or
oriented
use
cases.
By
integrating
diverse
sources—academic
publications,
trends,
responses—the
explores
multi-faceted
perspective
on
current
state
highlighting
gaps
between
focus,
practices,
public
interest.
notes
often
considered
an
individual
basis
instead
approached
broadly
set
mathematical
tools,
possibly
serving
barrier
expansive
means
practitioners
might
employ.
Язык: Английский
Interplay of Oxidative Stress, Gut Microbiota, and Nicotine in Metabolic-Associated Steatotic Liver Disease (MASLD)
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1532 - 1532
Опубликована: Дек. 14, 2024
Oxidative
stress
has
been
described
as
one
of
the
main
drivers
intracellular
damage
and
metabolic
disorders
leading
to
syndrome,
a
major
health
problem
worldwide.
In
particular,
free
radicals
alter
lipid
metabolism
promote
accumulation
in
liver,
existing
hepatic
facet
dysfunction-associated
steatotic
liver
disease
(MASLD).
Recent
literature
highlighted
how
nicotine,
especially
if
associated
with
high-fat
diet,
exerts
negative
effect
on
induction
progression
MASLD
by
upregulating
inflammation
increasing
oxidative
stress,
abdominal
fat
lipolysis,
lipogenesis.
Moreover,
considerable
evidence
shows
central
role
intestinal
dysbiosis
pathogenesis
impact
nicotine-induced
gut
microbiome.
This
results
an
intricate
network
which
stands
at
intersection
point
between
microbiome,
MASLD.
The
aim
this
review
is
delve
into
molecular
mechanisms
linking
tobacco
smoking
MASLD,
focusing
microbiota
modifications
their
development.
Язык: Английский
Global research trends on the associations between the microbiota and lung cancer: a visualization bibliometric analysis (2008–2023)
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 30, 2024
Numerous
papers
have
been
published
on
the
microbiota
in
lung
cancer
recent
years.
However,
there
is
still
a
lack
of
bibliometric
analysis
this
field.
Our
paper
did
analyses
and
elucidated
knowledge
structure
study
hotspots
related
to
patients.
We
screened
publications
reporting
from
2008
2023
Web
Science
Core
Collection
(WoSCC)
database,
carried
out
by
application
VOSviewers,
CiteSpace
R
package
"bibliometrix."
The
684
documents
enrolled
were
obtained
331
institutions
67
regions
4,661
authors
recorded
340
journals.
Annual
are
growing
rapidly,
countries
China,
United
States
Italy
contributing
most
area
research.
Zhejiang
University
main
research
organization.
Язык: Английский
Progress in the Study of Animal Models of Metabolic Dysfunction-Associated Steatotic Liver Disease
Nutrients,
Год журнала:
2024,
Номер
16(18), С. 3120 - 3120
Опубликована: Сен. 15, 2024
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
has
recently
been
proposed
as
an
alternative
term
to
NAFLD.
MASLD
is
a
globally
recognized
chronic
that
poses
significant
health
concerns
and
frequently
associated
with
obesity,
insulin
resistance,
hyperlipidemia.
To
better
understand
its
pathogenesis
develop
effective
treatments,
it
essential
establish
suitable
animal
models.
Therefore,
attempts
have
made
modelling
approaches
are
highly
similar
human
diet,
physiology,
pathology
replicate
progression.
Here,
we
reviewed
the
of
summarised
used
models
in
last
7
years
through
PubMed
database.
In
addition,
commonly
describe
advantages
disadvantages
various
induction,
including
genetic
models,
chemically
induced
provide
directions
for
research
on
treatment
MASLD.
Язык: Английский