Roles of HSP70 in autophagic protection of cardiomyocytes induced by heat acclimation: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142984 - 142984
Опубликована: Апрель 1, 2025
Язык: Английский
Autophagy activity in cardiac fibroblasts at the early stages of cardiac dysfunction induced by pressure overload
Russian Cardiology Bulletin,
Год журнала:
2025,
Номер
20(1), С. 13 - 13
Опубликована: Апрель 14, 2025
Despite
advancements
in
investigation
of
cardiac
fibrosis
mechanisms,
molecular
and
cellular
regulation
this
process
remains
insufficiently
explored.
In
context,
examination
novel
targets
capable
regulating
the
state
fibroblasts
their
profibrotic
properties
becomes
a
pivotal
area
research.
These
processes
include
autophagy
as
an
evolutionary
conservative
mechanism
contributing
to
maintenance
homeostasis
through
utilization
macromolecules
organelles
via
lysosomal
degradation
pathway.
The
objective
was
investigate
at
early
stages
dysfunction
caused
by
pressure
overload.
Experimental
studies
showed
that
modelling
transverse
aortic
constriction
promotes
overload
with
cardiomyocyte
hypertrophy,
perivascular
interstitial
accumulation
collagen.
morphological
changes
were
accompanied
reduced
activity
tissue.
A
detailed
bioinformatic
analysis
transcriptome
single
cells
revealed
not
expression
genes
associated
total
pool
its
subpopulations.
Thus,
demonstrated
differences
specialized
response
heart
compared
myocardial
cell
pool.
No
change
is
probably
favor
suppression
adaptation
tissue
new
conditions
functioning.
Autophagy
diagnostic
marker
progression
requires
confirmation
additional
studies.
Язык: Английский
Cordycepin Activates Autophagy to Suppress FGF9-induced TM3 Mouse Leydig Progenitor Cell Proliferation
Cancer Genomics & Proteomics,
Год журнала:
2024,
Номер
21(6), С. 630 - 644
Опубликована: Окт. 28, 2024
Background/Aim:
Fibroblast
growth
factor
9
(FGF9)
is
a
member
of
the
human
FGF
family
known
for
its
pivotal
roles
in
various
biological
processes,
such
as
cell
proliferation,
tissue
repair,
and
male
sex
determination
including
testis
formation.
Cordycepin,
bioactive
compound
found
Cordyceps
sinensis,
exhibits
potent
antitumor
effects
by
triggering
apoptosis
and/or
autophagy
pathways.
Our
research
has
unveiled
that
FGF9
promotes
proliferation
tumorigenesis
MA-10
mouse
Leydig
tumor
cells,
phenomena
are
effectively
countered
cordycepin
through
induction.
Moreover,
we
have
observed
FGF9-mediated
stimulation
TM3
progenitor
prompting
an
investigation
into
potential
inhibitory
effect
on
under
treatment.
Hence,
hypothesized
induces
death
via
FGF9-treated
cells.
Materials
Methods:
cells
were
treated
with
FGF9,
flow
cytometry,
immunofluorescent
plus
western
blotting
assays
used
to
determine
how
regulated
Results:
findings
reveal
restricts
viability
colony
formation
while
inducing
morphological
alterations
associated
Surprisingly,
fails
elicit
expression
key
apoptotic
markers,
suggesting
alternate
mechanism
action.
Although
certain
autophagy-related
proteins
remains
unaltered,
significant
up-regulation
LC3-II,
indicative
autophagy,
cordycepin-treated
influence.
inhibition
chloroquine
reverses
cordycepin-induced
death,
highlighting
crucial
role
this
process.
Conclusion:
study
demonstrates
activates
induce
treatment
conditions.
Язык: Английский