Ginseng Peptide Extract Mitigates Nicotine-Induced Human Aortic Endothelial Cells Oxidative Stress and Apoptosis by Maintaining the Keap1/Nrf2/HO-1 Signal Balance
Опубликована: Янв. 1, 2025
The
oxidative
damage
to
vascular
endothelial
cells
induced
by
smoking
represents
a
significant
pathogenic
factor
in
the
development
of
atherosclerosis.
In
present
study,
we
isolated
ginseng
oligopeptide
extract
(GOE),
which
emerges
as
promising
candidate
for
protecting
human
aortic
(HAECs)
from
stress
nicotine.
underlying
mechanisms
were
also
explored.
GOE
effectively
reversed
decline
cell
viability
and
protected
HAECs
BaP-induced
inhibiting
overproduction
intracellular
reactive
oxygen
species
(ROS)
while
preserving
superoxide
dismutase
(SOD)
activity.
We
identified
five
oligopeptides
(GOPs)
primary
components
GOE.
Furthermore,
demonstrated
that
significantly
alleviated
nicotine-induced
mitochondrial
dysfunction
promoting
nitric
oxide
(NO)
release
expression
GTP
cyclohydrolase
1
(GTPCH1).
Although
precise
mechanism
through
mitigates
remains
be
fully
elucidated,
our
findings
indicate
GOP-1~5
serve
bioactive
constituents
play
synergistic
role
reducing
apoptosis
damages
HAECs.
This
is
achieved
modulation
cellular
antioxidant
systems
via
maintaining
balance
within
Keap1/Nrf2/HO-1
signaling
pathway.
These
suggest
may
function
potential
therapeutic
agent
against
cigarette
smoking-induced
Язык: Английский
Research progress on anti-aging effects and mechanisms of the new ginsenoside Compound K
Deleted Journal,
Год журнала:
2025,
Номер
2(1), С. 100072 - 100072
Опубликована: Янв. 31, 2025
Язык: Английский
SIRT3 suppresses vascular endothelial senescence via DHRS2 and contributes to the anti-vascular aging effect of Bazi Bushen capsule
Phytomedicine,
Год журнала:
2025,
Номер
140, С. 156571 - 156571
Опубликована: Фев. 25, 2025
Язык: Английский
Gut Microbiota-Mediated Biotransformation of Medicinal Herb-Derived Natural Products: A Narrative Review of New Frontiers in Drug Discovery
J — Multidisciplinary Scientific Journal,
Год журнала:
2024,
Номер
7(3), С. 351 - 372
Опубликована: Сен. 4, 2024
The
discovery
of
natural
products
has
been
pivotal
in
drug
development,
providing
a
vast
reservoir
bioactive
compounds
from
various
biological
sources.
This
narrative
review
addresses
critical
research
gap:
the
largely
underexplored
role
gut
microbiota
mediation
and
biotransformation
medicinal
herb-derived
for
therapeutic
use.
By
examining
interplay
between
products,
this
highlights
potential
microbiota-mediated
to
unveil
novel
agents.
It
delves
into
mechanisms
by
which
microbes
modify
enhance
efficacy
with
focus
on
herbal
medicines
Ayurveda
traditional
Chinese
medicine,
known
their
applications
treating
metabolic
inflammatory
diseases.
also
discusses
recent
advances
microbiota-derived
product
research,
including
innovative
methodologies
such
as
culturomics,
metagenomics,
metabolomics.
exploring
intricate
interactions
microorganisms
substrates,
uncovers
new
strategies
leveraging
processes
development
groundbreaking
therapeutics.
Язык: Английский
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Язык: Английский
The brain-protective mechanism of fecal microbiota transplantation from young donor mice in the natural aging process via exosome, gut microbiota, and metabolomics analyses
Pharmacological Research,
Год журнала:
2024,
Номер
207, С. 107323 - 107323
Опубликована: Июль 23, 2024
The
natural
aging
process
is
accompanied
by
changes
in
exosomes,
gut
microbiota,
and
metabolites.
This
study
aimed
to
reveal
the
anti-aging
effect
mechanisms
of
fecal
microbiota
transplantation
(FMT)
from
young
donors
on
mice
analyzing
metabolomics.
Aging-relevant
telomeric
length,
oxidative
stress
indexes
brain
tissue,
serum
cytokine
levels
were
measured.
Flow
analysis
T-regulatory
(Treg),
CD4
Язык: Английский