3D-printed endovascular scaffold loaded with miR-199a-5p promotes the functional repair of atherosclerosis DOI Creative Commons
Min Xu, Mei Zhao

Materials Technology, Год журнала: 2024, Номер 39(1)

Опубликована: Ноя. 27, 2024

Among deaths related to cardiovascular disease (CVD), arteriosclerosis accounts for three-quarters of the total. The most common treatment is revascularization through implantation endovascular scaffolds. However, metal scaffolds currently available are non-biodegradable, which can lead rejection reactions. In this study, we have developed a CMCS-PEI/miR polysaccharide nucleic acid nanodrug loaded with miR-199a-5p first time. exhibits good blood compatibility, successfully transfects cells, and induces apoptosis vascular endothelial cells. Additionally, PCL/GO composite excellent mechanical properties biocompatibility were fabricated using 3D printing technology. This technology allows customisation meet needs individual patients. 3D-printed CMCS-PEI/miRNA effectively induce showing great potential in promoting functional repair preventing restenosis.

Язык: Английский

Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies DOI Creative Commons
Joseph Adu‐Amankwaah,

Qiang You,

Xinying Liu

и другие.

MedComm, Год журнала: 2025, Номер 6(3)

Опубликована: Март 1, 2025

Pulmonary hypertension (PH) stands as a tumor paradigm cardiovascular disease marked by hyperproliferation of cells and vascular remodeling, culminating in heart failure. Complex genetic epigenetic mechanisms collectively contribute to the disruption pulmonary homeostasis. In recent years, advancements research technology have identified numerous gene deletions mutations, addition bone morphogenetic protein receptor type 2, that are closely associated with remodeling process PH. Additionally, modifications such RNA methylation, DNA histone modification, noncoding RNAs been shown precisely regulate PH molecular networks cell-type-specific manner, emerging potential biomarkers therapeutic targets. This review summarizes analyzes roles currently genes factors PH, emphasizing pivotal role long ncRNAs its regulation. it examines current clinical preclinical therapies for targeting these explores new treatment strategies.

Язык: Английский

Процитировано

3
Crosstalk of glutamine metabolism between cancer-associated fibroblasts and cancer cells DOI
Tingyu Chen, Yiming Xu, Fan Yang

и другие.

Cellular Signalling, Год журнала: 2025, Номер 133, С. 111874 - 111874

Опубликована: Май 15, 2025

Язык: Английский

Процитировано

0
3,4-Dimethoxycinnamic acid from coffee silverskin biowaste ameliorates bleomycin-induced pulmonary fibrosis via modulating caveolin-1-dependent activation of NF-κB, TGF-β1/Smad3, and ERK1/2 signaling pathways DOI
Mahmoud Elshal, Abdelrahman Hamdi,

Iya Khalil

и другие.

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер 501, С. 117414 - 117414

Опубликована: Май 25, 2025

Язык: Английский

Процитировано

0
Role of inflammation in endothelial responses in Pulmonary Hypertension DOI
Aiping Wang, Pan Qin, Jing Zhang

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 188, С. 118206 - 118206

Опубликована: Май 28, 2025

Язык: Английский

Процитировано

0
3D-printed endovascular scaffold loaded with miR-199a-5p promotes the functional repair of atherosclerosis DOI Creative Commons
Min Xu, Mei Zhao

Materials Technology, Год журнала: 2024, Номер 39(1)

Опубликована: Ноя. 27, 2024

Among deaths related to cardiovascular disease (CVD), arteriosclerosis accounts for three-quarters of the total. The most common treatment is revascularization through implantation endovascular scaffolds. However, metal scaffolds currently available are non-biodegradable, which can lead rejection reactions. In this study, we have developed a CMCS-PEI/miR polysaccharide nucleic acid nanodrug loaded with miR-199a-5p first time. exhibits good blood compatibility, successfully transfects cells, and induces apoptosis vascular endothelial cells. Additionally, PCL/GO composite excellent mechanical properties biocompatibility were fabricated using 3D printing technology. This technology allows customisation meet needs individual patients. 3D-printed CMCS-PEI/miRNA effectively induce showing great potential in promoting functional repair preventing restenosis.

Язык: Английский

Процитировано

0