Medicinal Plant Extracts Targeting UV-Induced Skin Damage: Molecular Mechanisms and Therapeutic Potential
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2278 - 2278
Опубликована: Март 4, 2025
The
depletion
of
the
ozone
layer
has
intensified
ultraviolet
(UV)
radiation
exposure,
leading
to
oxidative
stress,
DNA
damage,
inflammation,
photoaging,
and
skin
cancer.
Medicinal
plants,
widely
used
in
Traditional
Herbal
Medicine
(THM),
particularly
Chinese
(TCM),
have
demonstrated
significant
therapeutic
potential
due
their
well-characterized
active
compounds
established
photoprotective
effects.
This
review
systematically
evaluates
18
medicinal
plants
selected
based
on
traditional
use
skin-related
conditions
emerging
evidence
supporting
efficacy
against
UV-induced
damage.
Their
bioactive
components
exert
antioxidant,
anti-inflammatory,
repair,
depigmentation
effects
by
modulating
key
signaling
pathways,
including
Nrf2/ARE-,
MAPK/AP-1-,
PI3K/Akt-,
MITF/TYR-related
melanogenesis
pathways.
Moreover,
novel
drug
delivery
systems,
such
as
exosomes,
hydrogels,
nanoemulsions,
significantly
enhanced
stability,
bioavailability,
penetration
these
compounds.
However,
challenges
remain
standardizing
plant-derived
formulations,
elucidating
complex
synergistic
mechanisms,
translating
preclinical
findings
into
clinical
applications.
Future
interdisciplinary
research
technological
advancements
will
be
essential
harness
full
for
damage
prevention
treatment.
Язык: Английский
The potential of natural herbal plants in the treatment and prevention of non-small cell lung cancer: An encounter between ferroptosis and mitophagy
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119555 - 119555
Опубликована: Фев. 1, 2025
Язык: Английский
Gold@Mesoporous Polydopamine Nanocomposite Hydrogel Loaded with Estrogen for the Treatment of Skin Photoaging
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 4571 - 4587
Опубликована: Апрель 1, 2025
Topical
application
of
17β-estradiol
(E2)
has
been
shown
to
improve
various
hallmark
features
skin
aging,
including
enhancing
elasticity
and
hydration,
reducing
wrinkles,
promoting
collagen
synthesis.
However,
the
role
estrogen
in
UVB-induced
photoaging
remains
unclear.
Furthermore,
E2's
clinical
is
limited
by
issues
such
as
bioavailability
potential
adverse
effects.
Therefore,
this
study
aims
explore
E2
prepare
a
gold
(Au)@mesoporous
polydopamine
(mPDA)-hyaluronic
acid
(HA)/carboxymethyl
chitosan
(CMCS)
nanoparticle
composite
hydrogel
(Au/E2@mPDA-HCG)
for
treatment
photoaging.
This
successfully
fabricated
mPDA
with
well-defined
mesoporous
structure
incorporated
Au
NPs
into
mesopores
using
an
situ
growth
method,
thereby
constructing
Au@mPDA
loaded
E2.
Subsequently,
Au/E2@mPDA
were
embedded
HA/CMCS
develop
Au/E2@mPDA-HCG
hydrogel.
The
was
characterized
through
vitro
vivo
experiments,
its
efficacy
improving
evaluated.
revealed
that
deficiency
significantly
exacerbates
photoaging,
likely
mechanisms
closely
associated
increased
oxidative
stress
reduced
production.
Moreover,
demonstrated
favorable
morphological
characteristics
biocompatibility.
In
experimental
results
indicated
effectively
enhanced
therapeutic
treating
evidenced
significant
mitigation
inflammatory
responses,
along
promotion
conclusion,
suggests
combination
Au@mPDA@HCG
nanocomposite
offers
promising
strategy
Язык: Английский