A versatile and double cross-linked hydrogel with potent antibacterial and immunomodulatory Zn@Met nanocomplexes for enhanced diabetic-infected wound healing
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 163942 - 163942
Опубликована: Май 1, 2025
Язык: Английский
Caloric Restriction Mimetics as Priming Agents of Mesenchymal Stem Cells Secretome to Enhance Regenerative Responses to Parkinson’s Disease
Molecules,
Год журнала:
2025,
Номер
30(11), С. 2260 - 2260
Опубликована: Май 22, 2025
Parkinson’s
disease
(PD)
is
a
neurodegenerative
disorder
primarily
defined
by
the
deterioration
of
motor
function
and
characterized
loss
dopaminergic
neurons
in
nigrostriatal
system.
Although
it
second
most
prevalent
central
nervous
system,
current
treatments
focus
on
symptom
management
modestly
slowing
progression,
ultimately
failing
to
preserve
long-term
quality
life
substantial
proportion
affected
individuals.
Innovative
therapies
that
can
restore
neuronal
have
emerged,
such
as
use
secretome
Mesenchymal
Stem
Cells
(MSCs)
due
their
rich
composition
bioactive
molecules.
This
therapy
exhibits
robust
paracrine
activity
drives
self-renewal
capacity,
differentiation
potential,
immune
regulation
MSCs
without
presenting
compatibility
issues
often
associated
with
stem
cell-based
therapies.
While
conceptually
appealing,
clinical
application
this
approach
still
limited
availability
proliferation
capacity
MSCs,
impacts
not
only
production
but
also
its
quality.
Various
protocols
been
developed
enhance
action
adding
various
compounds
cell
culture
media,
given
high
environmental
plasticity
MSCs.
Some
already
used
are
Caloric
Restriction
Mimetics
(CRMs),
molecules
mimic
(CR)
conditions,
which
demonstrated
extend
lifespan
reduce
age-related
diseases
organisms.
sufficient
cure
disorders,
these
may
potentiate
efficiency
enhancing
autophagy
pathways
relieving
oxidative
stress
burden
from
Therefore,
article,
we
aim
explore
effects
CRMs
priming
how
help
bridge
existing
gaps
regenerative
for
PD.
Язык: Английский
Suppressing the Aging Phenotype of Mesenchymal Stromal Cells: Are We Ready for Clinical Translation?
Biomedicines,
Год журнала:
2024,
Номер
12(12), С. 2811 - 2811
Опубликована: Дек. 11, 2024
Mesenchymal
stem/stromal
cells
(MSCs)
are
involved
in
the
maintenance
and
regeneration
of
a
large
variety
tissues
due
to
their
stemness
multi-lineage
differentiation
capability.
Harnessing
these
advantageous
features,
flurry
clinical
trials
have
focused
on
MSCs
treat
different
pathologies,
but
only
few
protocols
received
regulatory
approval
so
far.
Among
various
causes
hindering
MSCs'
efficacy
is
emergence
cellular
senescence,
which
has
been
correlated
with
specific
characteristics,
such
as
morphological
epigenetic
alterations,
DNA
damage,
ROS
production,
mitochondrial
dysfunction,
telomere
shortening,
non-coding
RNAs,
loss
proteostasis,
peculiar
senescence-associated
secretory
phenotype.
Several
strategies
investigated
for
delaying
or
even
hopefully
reverting
onset
assessed
by
senescent
phenotype
MSCs.
Here,
authors
reviewed
most
updated
literature
potential
particular
emphasis
current
future
therapeutic
approaches
aimed
at
senescence
and/or
extending
functional
lifespan
stem
cells.
Язык: Английский