Protective Effects of Nerolidol on Thrombotic Events, Systemic Inflammation, Oxidative Stress, and DNA Damage Following Pulmonary Exposure to Diesel Exhaust Particles DOI Creative Commons

Naserddine Hamadi,

Sumaya Beegam,

Nur Elena Zaaba

и другие.

Biomedicines, Год журнала: 2025, Номер 13(3), С. 729 - 729

Опубликована: Март 17, 2025

Background/Objectives: Inhalation of environmental particulate air pollution has been reported to cause pulmonary and systemic events including coagulation disturbances, inflammation, oxidative stress. Nerolidol, a naturally occurring sesquiterpene alcohol, effective antioxidant anti-inflammatory effects. Hence, the aim in present investigation was evaluate potential ameliorative effects nerolidol on actions induced by exposure diesel exhaust particles (DEPs). Methods: Nerolidol (100 mg/kg) given mice oral gavage one hour before intratracheal instillation DEPs (0.5 mg/kg), 24 h later various markers toxicity were evaluated. Results: treatment significantly abrogated DEP-induced platelet aggregation vivo vitro. also prevented shortening prothrombin time activated plasma thromboplastin triggered DEP exposure. Likewise, while concentrations fibrinogen plasminogen activator inhibitor-1 increased administration, that tissue decreased. These abolished group concomitantly treated with DEP. Moreover, stress, endothelial dysfunction which DEP-treated group, returned control levels + group. ameliorated increase hypoxia-inducible factor 1α, galectin-3, neutrophil gelatinase-associated lipocalin The co-administration mitigated DNA damage, 8-hydroxy-2-deoxyguanosine, apoptosis, cleaved-caspase-3, Conclusions: Collectively, our data demonstrate exert significant against thrombotic events, dysfunction, apoptosis. Pending further pharmacological toxicological studies, could be promising agent alleviate inhaled other pollutant particles.

Язык: Английский

Protective Effects of Nerolidol on Thrombotic Events, Systemic Inflammation, Oxidative Stress, and DNA Damage Following Pulmonary Exposure to Diesel Exhaust Particles DOI Creative Commons

Naserddine Hamadi,

Sumaya Beegam,

Nur Elena Zaaba

и другие.

Biomedicines, Год журнала: 2025, Номер 13(3), С. 729 - 729

Опубликована: Март 17, 2025

Background/Objectives: Inhalation of environmental particulate air pollution has been reported to cause pulmonary and systemic events including coagulation disturbances, inflammation, oxidative stress. Nerolidol, a naturally occurring sesquiterpene alcohol, effective antioxidant anti-inflammatory effects. Hence, the aim in present investigation was evaluate potential ameliorative effects nerolidol on actions induced by exposure diesel exhaust particles (DEPs). Methods: Nerolidol (100 mg/kg) given mice oral gavage one hour before intratracheal instillation DEPs (0.5 mg/kg), 24 h later various markers toxicity were evaluated. Results: treatment significantly abrogated DEP-induced platelet aggregation vivo vitro. also prevented shortening prothrombin time activated plasma thromboplastin triggered DEP exposure. Likewise, while concentrations fibrinogen plasminogen activator inhibitor-1 increased administration, that tissue decreased. These abolished group concomitantly treated with DEP. Moreover, stress, endothelial dysfunction which DEP-treated group, returned control levels + group. ameliorated increase hypoxia-inducible factor 1α, galectin-3, neutrophil gelatinase-associated lipocalin The co-administration mitigated DNA damage, 8-hydroxy-2-deoxyguanosine, apoptosis, cleaved-caspase-3, Conclusions: Collectively, our data demonstrate exert significant against thrombotic events, dysfunction, apoptosis. Pending further pharmacological toxicological studies, could be promising agent alleviate inhaled other pollutant particles.

Язык: Английский

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