Nutrients, Год журнала: 2025, Номер 17(2), С. 267 - 267

Опубликована: Янв. 13, 2025

Biological aging is a substantial change that leads to different diseases, including osteoporosis (OP), condition involved in loss of bone density, deterioration structure, and increased fracture risk. In old people, there natural decline mineral density (BMD), exacerbated by hormonal changes, particularly during menopause, it continues the early postmenopausal years. During this transition time, alterations are linked elevated oxidative stress (OS) decreased antioxidant defenses, leading significant increase OP. Aging significantly associated with an abnormal ratio oxidant/antioxidant modified nuclear factor erythroid-derived two related factor2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway. OS adversely affects health promoting osteoclastic (bone resorbing) activity impairing osteoblastic (bone-forming cells). Nrf2 critical controlling various cellular processes. The expression multiple age-related OP, deficiency unbalanced formation/resorption consequent mass. Various drugs available for treating OP; however, long-term uses these medicines implicated diverse illnesses such as cancer, cardiovascular, stroke. At same categories products, particular flavonoids, were proposed safe alternatives anti-osteoporotic effects.

Язык: Английский