Patchoulene epoxide mitigates colitis and hepatic damage induced by dextran sulfate sodium by regulating the colonic microbiota and purine metabolism DOI Creative Commons
Chen Li-ping, Lili Xie, Li‐Fen Wang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 14, 2025

Introduction Ulcerative colitis (UC) is often characterized by dysbiosis of the colonic microbiota and metabolic disturbances, which can lead to liver damage. Patchoulene epoxide (PAO), a tricyclic sesquiterpene derived from aged essential oil Pogostemonis Herba, known for its anti-inflammatory ulcer-healing properties. However, dual protective role against UC injury remains largely unexplored. This study aims elucidate effect underlying mechanism PAO dextran sulfate sodium (DSS)-induced in mice. Methods Colitis mice were induced adding 3% DSS their drinking water continuously 7 days, at doses 20 40 mg/kg was administered orally daily first day until experimental endpoint. Stool consistency scores, blood stool body weights recorded weekly. Disease activity index (DAI) determined before necropsy, where colon tissues collected biochemical analyses. Additionally, fecal microbiome metabolites treated using 16S rRNA amplicon sequencing metabolomics. Results significantly reduced disease mitigated atrophy It also improved hepatic pathological changes safeguarding tight adherens junctions, suppressing generation pro-inflammatory cytokines lipopolysaccharide. These beneficial effects attributed PAO’s capability regulate processes. found enhance diversity shift microbial balance Specifically, it restored an Akkermansia-dominated state, characteristic UC, healthier Muribaculaceae-dominated composition. Furthermore, corrected disturbance modulating purine metabolism, notably increasing abundance deoxyadenosine, adenosine guanine Conclusions The therapeutic on mainly regulation metabolism. insights emphasize overall benefits treating injury.

Язык: Английский

Targeting Bile-Acid Metabolism: Nutritional and Microbial Approaches to Alleviate Ulcerative Colitis DOI Open Access
Xiaoxin Jiang, Jingyi Ren,

Gejun Yu

и другие.

Nutrients, Год журнала: 2025, Номер 17(7), С. 1174 - 1174

Опубликована: Март 28, 2025

Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colorectum, posing significant global health burden. Recent studies highlight critical role of gut microbiota and its metabolites, particularly bile acids (BAs), in UC's pathogenesis. The relationship between BAs bidirectional: influence BA composition, while regulate diversity activity through receptors like Farnesoid X receptor (FXR) Takeda G protein-coupled 5 (TGR5). Targeting bile-acid metabolism to reshape presents promising therapeutic strategy for UC. This review examines classification synthesis BAs, their interactions with microbiota, potential nutritional microbial interventions. By focusing on these therapies, we aim offer innovative approaches effective UC management.

Язык: Английский

Процитировано

0
Patchoulene epoxide mitigates colitis and hepatic damage induced by dextran sulfate sodium by regulating the colonic microbiota and purine metabolism DOI Creative Commons
Chen Li-ping, Lili Xie, Li‐Fen Wang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 14, 2025

Introduction Ulcerative colitis (UC) is often characterized by dysbiosis of the colonic microbiota and metabolic disturbances, which can lead to liver damage. Patchoulene epoxide (PAO), a tricyclic sesquiterpene derived from aged essential oil Pogostemonis Herba, known for its anti-inflammatory ulcer-healing properties. However, dual protective role against UC injury remains largely unexplored. This study aims elucidate effect underlying mechanism PAO dextran sulfate sodium (DSS)-induced in mice. Methods Colitis mice were induced adding 3% DSS their drinking water continuously 7 days, at doses 20 40 mg/kg was administered orally daily first day until experimental endpoint. Stool consistency scores, blood stool body weights recorded weekly. Disease activity index (DAI) determined before necropsy, where colon tissues collected biochemical analyses. Additionally, fecal microbiome metabolites treated using 16S rRNA amplicon sequencing metabolomics. Results significantly reduced disease mitigated atrophy It also improved hepatic pathological changes safeguarding tight adherens junctions, suppressing generation pro-inflammatory cytokines lipopolysaccharide. These beneficial effects attributed PAO’s capability regulate processes. found enhance diversity shift microbial balance Specifically, it restored an Akkermansia-dominated state, characteristic UC, healthier Muribaculaceae-dominated composition. Furthermore, corrected disturbance modulating purine metabolism, notably increasing abundance deoxyadenosine, adenosine guanine Conclusions The therapeutic on mainly regulation metabolism. insights emphasize overall benefits treating injury.

Язык: Английский

Процитировано

0