Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 31, 2025
Neurological
disorders
pose
significant
global
public
health
challenges,
with
a
rising
prevalence
and
complex
pathophysiological
mechanisms
that
impose
substantial
social
economic
burdens.
Traditional
Chinese
Medicine
(TCM),
its
holistic
approach
multi-target
effects,
has
gained
increasing
attention
in
the
treatment
of
neurological
diseases.
This
review
explores
bioactive
compounds
derived
from
herbal
plants,
focusing
on
their
action,
underlying
pathways,
potential
applications
functional
food
development.
The
highlights
neuroprotective
properties
flavonoids,
alkaloids,
polysaccharides,
polyphenols
found
key
TCM
herbs
such
as
Scutellaria
baicalensis
,
Salvia
miltiorrhiza
Ligusticum
chuanxiong
Gastrodia
elata
.
These
have
demonstrated
anti-inflammatory,
antioxidant,
neurogenic
making
them
promising
candidates
for
prevention
conditions,
including
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
depression.
Furthermore,
synergistic
effects
formulations
targeting
multiple
signaling
pathways
offer
advantages
over
single-target
therapies,
especially
combating
neurodegenerative
also
discusses
challenges
future
directions
integrating
these
into
foods
dietary
supplements,
aiming
to
improve
enhance
clinical
outcomes.
Ultimately,
this
work
aims
provide
valuable
insights
TCM-based
interventions
promoting
well-being
addressing
burden
disorders.
Язык: Английский
Schaftoside Reduces Depression- and Anxiogenic-like Behaviors in Mice Depression Models
Hu Yue,
Yaoxue Gan,
Lei Jia
и другие.
Brain Sciences,
Год журнала:
2025,
Номер
15(3), С. 238 - 238
Опубликована: Фев. 24, 2025
Background:
Major
depressive
disorder
is
a
common
mental
health
issue
characterized
by
persistently
low
mood
and
high
morbidity
mortality.
The
major
pathophysiology
neuroinflammation,
as
evidenced
elevated
cytokine
levels.
Patients
often
fail
to
achieve
full
remission
with
the
use
of
currently
available
antidepressants,
prompting
search
for
new
treatment
options.
Schaftoside
(SS),
flavonoid
found
in
traditional
Chinese
herbs,
has
both
antioxidant
anti-inflammatory
properties.
However,
its
antidepressant
effects
are
poorly
understood.
Methods:
Male
C57BL/6
mice
underwent
chronic
unpredictable
mild
stress
(CUMS)
lipopolysaccharide
(LPS)
induce
depression-
anxiety-like
behaviors.
SS
was
administered
at
40,
80,
160
mg/kg
28
days.
effect
on
depression-like
behaviors
assessed
using
behavioral
assays,
ELISA
used
measure
pro-inflammatory
cytokines
serum
hippocampus.
Results:
significantly
decreased
immobility
forced
swim
tail
suspension
tests,
increased
sucrose
preference
test,
reduced
feeding
latency
novelty-suppressed
test.
These
findings
indicate
improved
depression
showed
that
lowered
interleukin-1
beta
(IL-1β),
IL-6,
tumor
necrosis
factor-alpha
levels
hippocampus
CUMS
mice.
Conclusions:
Our
study
indicates
anxiolytic
effects,
possibly
through
neuroinflammatory
processes,
making
it
promising
therapeutic
candidate
depression,
thus
deserves
further
investigation
into
mechanisms
clinical
efficacy.
Язык: Английский
Potential of Curcumin and Its Analogs in Glioblastoma Therapy
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 351 - 351
Опубликована: Март 18, 2025
Curcumin,
a
polyphenol
found
in
turmeric,
demonstrates
multifaceted
anti-cancer
activity
against
glioblastoma.
Its
therapeutic
potential
stems
from
its
ability
to
modulate
various
molecular
pathways
implicated
glioblastoma
development
and
progression,
enhance
the
effectiveness
of
radiation
therapy,
induce
cancer
cell
death
through
diverse
mechanisms,
including
apoptosis,
autophagy,
cycle
arrest.
These
combined
actions
make
curcumin
promising
candidate
for
treatment,
warranting
further
investigation
into
clinical
application.
In
this
review,
we
summarize
latest
research
on
analogs'
therapy.
Язык: Английский
Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases
Expert Opinion on Drug Delivery,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 5, 2025
It
is
anticipated
that
the
prevalence
of
illnesses
affecting
central
nervous
system
(CNS)
will
rise
significantly
due
to
longer
lifespans
and
changing
demography.
Age-related
decline
in
brain
function
neuronal
death
are
features
neurodegenerative
disorders,
such
as
Parkinson's
disease,
Alzheimer's
Huntington's
amyotrophic
lateral
sclerosis,
which
provide
formidable
treatment
challenges.
Because
most
therapeutic
drugs
cannot
pass
across
blood-brain
barrier
(BBB)
reach
brain,
there
still
few
alternatives
available
despite
a
great
deal
research.
This
study
explores
role
redox
chemical
delivery
systems
CNS
drug
addresses
challenges
associated
with
disease
(ND).
Redox
Chemical
Delivery
System
offers
promising
approach
enhancing
leveraging
reactions
facilitate
transport
agents
BBB.
Through
optimization
medication
pathways
this
technology
has
potential
greatly
improve
ND.
As
our
understanding
biological
underpinnings
ND
deepens,
for
effective
interventions
increases.
Refining
strategies,
RCDS,
essential
advancing
therapies
from
research
clinical
practice.
These
advancements
could
transform
management
ND,
improving
both
efficacy
patient
outcomes.
Язык: Английский
Evaluation of antioxidant properties, sensory profile of encapsulated spice oleoresins and molecular docking studies for the anti-depressive potential of their active components
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106545 - 106545
Опубликована: Апрель 1, 2025
Язык: Английский
Exploring the Effects of Natural Antioxidants in Neurodegenerative Diseases: A Comprehensive Review
International Journal For Multidisciplinary Research,
Год журнала:
2024,
Номер
6(6)
Опубликована: Дек. 29, 2024
Neurodegenerative
diseases
are
increasingly
becoming
a
significant
public
health
concern,
highlighting
an
urgent
need
for
effective
therapeutic
strategies.
This
comprehensive
review
delves
into
the
potential
of
natural
antioxidants,
such
as
Curcuminoids,
Vitamin
C,
E,
and
Resveratrol
in
preventing
treating
these
diseases.
We
examine
existing
evidence
neuroprotective
effects
compounds,
discuss
their
underlying
mechanisms,
emphasize
role
adjunctive
therapies
neurodegenerative
conditions
Язык: Английский