2017 IEEE International Ultrasonics Symposium (IUS),
Год журнала:
2023,
Номер
unknown, С. 1 - 4
Опубликована: Сен. 3, 2023
Photoacoustic
imaging
(PAI)
offers
a
unique
molecular
contrast
capable
of
solving
difficult
biomedical
tasks.
Conventional
systems
are
based
on
piezoelectric
transducers,
leveraging
established
acoustic
detection
methods
utilized
in
ultrasound
imaging,
but
such
complex
and
costly,
limiting
the
exploration
PAI
applications.
opportunity
for
optical
methods,
which
provide
larger
bandwidth,
better
low
frequency
response,
smaller
sensor
footprints
compared
to
transducer
arrays.
A
Fabry-Pérot
etalon
(FPE)
provides
highly
sensitive
resonant
cavity
photoacoustic
(PA)
waves.
However,
FPE
surface
relies
raster
scanning
aperture
at
each
point,
producing
an
inherent
temporal
limitation
pulse
repetition
rate
excitation
laser.
This
paper
studies
combination
PA
waves
with
compressed
sensing
techniques
used
ultrafast
photography
order
capture
entire
single
Results
image
reconstruction
data
set
simulated
blood
vessel
images
shown,
along
discussions
about
quality
versus
signal-to
noise
ratio
complexity.
Journal of Biomedical Optics,
Год журнала:
2023,
Номер
28(12)
Опубликована: Июнь 8, 2023
Photoacoustic
imaging
(PAI)
enables
the
visualization
of
optical
contrast
with
ultrasonic
imaging.
It
is
a
field
intense
research,
great
promise
for
clinical
application.
Understanding
principles
PAI
important
engineering
research
and
image
interpretation.
Advanced Photonics Nexus,
Год журнала:
2023,
Номер
2(05)
Опубликована: Июль 24, 2023
Photoacoustic
imaging
(PAI),
recognized
as
a
promising
biomedical
modality
for
preclinical
and
clinical
studies,
uniquely
combines
the
advantages
of
optical
ultrasound
imaging.
Despite
PAI's
great
potential
to
provide
valuable
biological
information,
its
wide
application
has
been
hindered
by
technical
limitations,
such
hardware
restrictions
or
lack
biometric
information
required
image
reconstruction.
We
first
analyze
limitations
PAI
categorize
them
seven
key
challenges:
limited
detection,
low-dosage
light
delivery,
inaccurate
quantification,
numerical
reconstruction,
tissue
heterogeneity,
imperfect
segmentation/classification,
others.
Then,
because
deep
learning
(DL)
increasingly
demonstrated
ability
overcome
physical
modalities,
we
review
DL
studies
from
past
five
years
that
address
each
challenges
in
PAI.
Finally,
discuss
promise
future
research
directions
DL-enhanced
Advanced Drug Delivery Reviews,
Год журнала:
2024,
Номер
205, С. 115177 - 115177
Опубликована: Янв. 5, 2024
Monitoring
brain
responses
to
ultrasonic
interventions
is
becoming
an
important
pillar
of
a
growing
number
applications
employing
acoustic
waves
actuate
and
cure
the
brain.
Optical
interrogation
living
tissues
provides
unique
means
for
retrieving
functional
molecular
information
related
activity
disease-specific
biomarkers.
The
hybrid
optoacoustic
imaging
methods
have
further
enabled
deep-tissue
with
optical
contrast
at
high
spatial
temporal
resolution.
marriage
between
light
sound
thus
brings
together
highly
complementary
advantages
both
modalities
toward
precision
interrogation,
stimulation,
therapy
strong
impact
in
fields
ultrasound
neuromodulation,
gene
drug
delivery,
or
noninvasive
treatments
neurological
neurodegenerative
disorders.
In
this
review,
we
elaborate
on
current
advances
monitoring
interventions.
We
describe
main
principles
mechanisms
underlying
each
method
before
diving
into
corresponding
biomedical
applications.
identify
areas
improvement
as
well
promising
approaches
clinical
translation
potential.
Photoacoustics,
Год журнала:
2023,
Номер
31, С. 100521 - 100521
Опубликована: Июнь 1, 2023
Optoacoustic
tomography
is
commonly
performed
with
bulky
and
expensive
short-pulsed
solid-state
lasers
providing
high
per-pulse
energies
in
the
millijoule
range.
Light
emitting
diodes
(LEDs)
represent
a
cost-effective
portable
alternative
for
optoacoustic
signal
excitation
that
can
additionally
provide
excellent
pulse-to-pulse
stability.
Herein,
we
introduce
full-view
LED-based
(FLOAT)
system
deep
tissue
vivo
imaging.
It
based
on
custom-made
electronic
unit
driving
stacked
array
of
LEDs,
which
attains
100
ns
pulse
width
highly
stable
(0.62
%
standard
deviation)
total
energy
0.48
mJ.
The
illumination
source
integrated
into
circular
cylindrically-focused
ultrasound
detection
elements
to
result
tomographic
configuration,
plays
critical
role
circumventing
limited-view
effects,
enhancing
effective
field-of-view
image
quality
cross-sectional
(2D)
We
characterized
FLOAT
performance
terms
width,
power
stability,
light
distribution,
signal-to-noise
penetration
depth.
human
finger
revealed
comparable
imaging
achieved
pulsed
Nd:YAG
laser.
anticipated
this
compact,
affordable
versatile
technology
will
facilitate
developments
resource-limited
settings
biological
clinical
applications.
Sensors,
Год журнала:
2024,
Номер
24(9), С. 2670 - 2670
Опубликована: Апрель 23, 2024
Photoacoustic
imaging
(PAI)
is
a
rapidly
developing
emerging
non-invasive
biomedical
technique
that
combines
the
strong
contrast
from
optical
absorption
and
high
resolution
acoustic
imaging.
Abnormal
biological
tissues
(such
as
tumors
inflammation)
generate
different
levels
of
thermal
expansion
after
absorbing
energy,
producing
distinct
signals
normal
tissues.
This
can
detect
small
tissue
lesions
in
has
demonstrated
significant
potential
for
applications
tumor
research,
melanoma
detection,
cardiovascular
disease
diagnosis.
During
process
collecting
photoacoustic
PAI
system,
various
factors
influence
signals,
such
absorption,
scattering,
attenuation
A
single
ultrasound
transducer
cannot
provide
sufficient
information
to
reconstruct
high-precision
images.
To
obtain
more
accurate
clear
image
reconstruction
results,
systems
typically
use
large
number
transducers
collect
multi-channel
angles
positions,
thereby
acquiring
about
signals.
Therefore,
high-quality
images,
require
measurement
which
result
substantial
hardware
time
costs.
Compressed
sensing
an
algorithm
breaks
through
Nyquist
sampling
theorem
original
signal
with
based
on
compressed
made
breakthroughs
over
past
decade,
enabling
low
artifacts
images
improving
efficiency,
reducing
article
provides
detailed
introduction
sensing,
physical
transmission
model-based
method,
two-stage
reconstruction-based
single-pixel
camera-based
method.
Challenges
future
perspectives
sensing-based
are
also
discussed.
Journal of Biomedical Optics,
Год журнала:
2025,
Номер
30(04)
Опубликована: Апрель 11, 2025
Optoacoustic
tomography
systems
commonly
employ
bulky
and
expensive
solid-state
laser
sources
readily
capable
of
generating
dozens
millijoules
optical
energy
per
pulse.
Light-emitting
diodes
(LEDs)
may
offer
a
significantly
more
affordable
compact
solution
with
excellent
pulse-to-pulse
stability.
Yet,
the
design
must
optimize
density
delivered
to
target,
given
relatively
low
per-pulse
output
LEDs.
We
exploit
full-view
LED-based
optoacoustic
(FLOAT)
configuration
for
in
vivo
imaging
mice.
The
system
features
panoramic
light
illumination
delivering
0.48
mJ
total
an
array
160
LEDs
stacked
into
cylindrically
focused
circular
ultrasound
transducer.
characterize
performance
FLOAT
tissue-mimicking
phantoms,
subsequently
demonstrating
its
ability
cross-sectional
mouse
imaging.
It
is
anticipated
that
compact,
low-cost
will
open
up
new
venues
resource-limited
settings
studying
large-scale
biodynamics
such
as
pharmacokinetics
biodistribution
molecular
agents
drugs
on
whole-body
level.
