An amplification mechanism for weak ELF magnetic fields quantum-bio effects in cancer cells

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 23, 2025

Язык: Английский

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Accelerating an integrative view of quantum biology

Frontiers in Physiology, Год журнала: 2024, Номер 14

Опубликована: Янв. 11, 2024

Quantum biology studies span multiple disciplines including physics, engineering, and with the goal of understanding quantum underpinnings living systems. Recent findings have brought wide attention to role mechanisms in function regulation biological processes. Moreover, a number activities been integral building vibrant community. Due inherent interdisciplinary nature field, it is challenge for researchers integrate advance across physical disciplines. Here we outline achievable approaches developing shared platform-including establishment standardized manipulation tools sensors, common scientific lexicon. Building community framework also crucial fostering robust collaborations, enhancing knowledge sharing, diversifying participation biology. A unified approach promises not only deepen our systems at level but accelerate frontiers medical technological innovations.

Язык: Английский

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Harmonizing Magnetic Mitohormetic Regenerative Strategies: Developmental Implications of a Calcium–Mitochondrial Axis Invoked by Magnetic Field Exposure

Bioengineering, Год журнала: 2023, Номер 10(10), С. 1176 - 1176

Опубликована: Окт. 10, 2023

Mitohormesis is a process whereby mitochondrial stress responses, mediated by reactive oxygen species (ROS), act cumulatively to either instill survival adaptations (low ROS levels) or produce cell damage (high levels). The mitohormetic nature of extremely low-frequency electromagnetic field (ELF-EMF) exposure thus makes it susceptible extraneous influences that also impinge on production and contribute the collective response. Consequently, magnetic stimulation paradigms are prone experimental variability depending diverse circumstances. failure, inability, control for these factors has contributed existing discrepancies between published reports in interpretations made from results generated therein. Confounding environmental include ambient fields, temperature, mechanical environment, conventional use aminoglycoside antibiotics. Biological type seeding density as well developmental, inflammatory, senescence statuses cells depend prior handling sample. Technological aspects directionality, uniformity, amplitude, duration exposure. All will exhibit manifestations at level culminate unified cellular response conjunction with Fortunately, many under experimenter. This review focus delineating areas requiring technical biological harmonization assist designing therapeutic strategies more clearly defined better predicted outcomes improve mechanistic interpretation data, rather than precise applications. explore underlying similarities other forms biophysical stimuli, such mutually induce elevations intracellular calcium prerequisite outcome. These stimuli commonly invoke activity transient receptor potential cation channel classes, TRPC1.

Язык: Английский

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Quantitative measurements of reactive oxygen species partitioning in electron transfer flavoenzyme magnetic field sensing

Frontiers in Physiology, Год журнала: 2024, Номер 15

Опубликована: Фев. 2, 2024

Biological magnetic field sensing that gives rise to physiological responses is of considerable importance in quantum biology. The radical pair mechanism (RPM) a fundamental process can explain some the observed biological effects. In magnetically sensitive (RP) reactions, coherent spin dynamics between singlet and triplet pairs are modulated by weak fields. resulting reaction products lead distinct signaling channels cellular outcomes. A prevalent RP biology flavin semiquinone superoxide (O 2 •− ) activation molecular oxygen. This result partitioning reactive oxygen species (ROS) form either O or hydrogen peroxide (H ). Here, we examine recombinant human electron transfer flavoenzyme (ETF) reoxidation selectively measuring H product distributions. ROS was two static fields at 20 nT 50 μT, with 13% decrease 10% increase relative µT. RPM yields were calculated for realistic flavin/superoxide across range fields, agreement experimental results. For born RP, also predicts about three times more than , results exhibiting four time produced ETF. method presented here illustrates potential novel flavoprotein sensor directly linked mitochondria bioenergetics be used as target study cell physiology.

Язык: Английский

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Therapeutic nuclear magnetic resonance and intermittent hypoxia trigger time dependent on/off effects in circadian clocks and confirm a central role of superoxide in cellular magnetic field effects

Redox Biology, Год журнала: 2024, Номер 72, С. 103152 - 103152

Опубликована: Апрель 5, 2024

Cellular magnetic field effects are assumed to base on coherent singlet-triplet interconversion of radical pairs that sensitive applied radiofrequency (RF) and weak fields (WEMFs), known as pair mechanism (RPM). As a leading model, the RPM explains how quantum can influence biochemical cellular signalling. Consequently, generate reactive oxygen species (ROS) link redox processes, such response hypoxia circadian clock. Therapeutic nuclear resonance (tNMR) occupies unique position in paradigm because used frequencies, which far below range 0.1-100 MHz postulated for occur. Nonetheless, tNMR was shown induce like effects, increased extracellular H2O2 levels altered bioenergetics. In this study we compared impact intermittent clock, well role superoxide induced ROS partitioning. We show both, hypoxia, exert on/off clocks dependent time application (day versus night). addition, our data provide further evidence plays central signal transduction. combination with scavengers, Vitamin C, led strong product redistributions. This discovery might represent first indication triads biological systems.

Язык: Английский

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Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians

Heliyon, Год журнала: 2025, Номер 11(2), С. e41833 - e41833

Опубликована: Янв. 1, 2025

Regeneration is the ability to accurately regrow missing body parts. The unparalleled regenerative capacity and incredible tissue plasticity of planarians, both resulting from presence abundant adult stem cells referred as neoblasts, offer a unique opportunity investigate cellular molecular principles underlying regeneration. Neoblasts are capable self-renewal differentiation into desired cell types for correct replacement lost parts after damage. Positional information in muscle governs polarity patterning plan during homeostasis For removal neoblasts disables feats disruption positional results regeneration inappropriate regions, only combination enables Here, I summarize current state field neoblast lineage potential, subclasses specification, roles proper turnover planarians.

Язык: Английский

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Magneto-oncology: a radical pair primer

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Март 7, 2025

There are few well-established biophysical mechanisms by which external magnetic fields can influence the biochemistry of molecules in living systems. The radical pair mechanism is arguably most promising. In this mini-review I summarize characteristics pairs a way that may be useful to those engaged field magneto-oncology. intention help researchers decide whether an observed biomedical effect could have its origin biochemistry. Armed with physically plausible interaction mechanism, it possible devise and refine theoretical model thereby iteratively optimise therapeutic protocols. Such approach also identify experimental artefacts

Язык: Английский

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The impact of ketamine and thiopental anesthesia on ultraweak photon emission and oxidative-nitrosative stress in rat brains

Frontiers in Systems Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Март 21, 2025

Anesthetics such as ketamine and thiopental, commonly used for inducing unconsciousness, have distinct effects on neuronal activity, metabolism, cardiovascular respiratory systems. Ketamine increases heart rate blood pressure while preserving function, whereas thiopental decreases both can cause depression. This study investigates the impact of (100 mg/kg) (45 ultraweak photon emission (UPE), oxidative-nitrosative stress, antioxidant capacity in isolated rat brains. To our knowledge, no previous has investigated compared UPE presence absence anesthesia. Here, we compare anesthetics with each other a non-anesthetized control group. increased UPE, lipid peroxidation, enzyme activity reducing thiol levels. Conversely, decreased oxidative markers, increasing was negatively correlated levels positively stress markers. These findings suggest that contrasting are linked to their differing impacts brain capacity. research suggests potential method monitor via during anesthesia, opens up new ways understanding managing anesthetic effects.

Язык: Английский

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Radical pair mechanism and the role of chirality-induced spin selectivity during planaria regeneration

Applied Physics Letters, Год журнала: 2024, Номер 125(10)

Опубликована: Сен. 2, 2024

Planaria serve as an intriguing model system wherein the effects of electric and magnetic fields on various biochemical pathways during cell morphogenesis can be studied. Recent experimental observations have demonstrated non-trivial modulation reactive oxygen species (ROS) levels by a weak field (WMF) planaria regeneration. However, underlying biophysical mechanism behind this remains elusive. In work, we investigate role radical pair (RPM) attempt to explain results effect WMFs ROS We also propose that instead flavin adenine dinucleotide-superoxide (FADH•−O2•−), non-superoxide-based dinucleotide-tryptophan (FAD•−−TrpH•+) might more suitable (RP) candidate for observed modulation. chirality-induced spin selectivity including it in framework RPM. conclude singlet initiated FAD•−−TrpH•+ is realistic choice RP, hence, superoxide formation happen later not RP dynamics.

Язык: Английский

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Construction and Application of a Static Magnetic Field Exposure Apparatus for Biological Research in Aqueous Model Systems and Cell Culture

BIO-PROTOCOL, Год журнала: 2024, Номер 14(1354)

Опубликована: Янв. 1, 2024

With the growth of quantum biology field, study magnetic field (MF) effects on biological processes and their potential therapeutic applications has attracted much attention. However, most biologists lack experience needed to construct an MF exposure apparatus own, no consensus standard exists for methods, protocols model organisms are sorely lacking. We aim provide those interested in entering with ability investigate static own research. This protocol covers how design, build, calibrate, operate a chamber (MagShield apparatus), instructions modify parameters other specific needs. The MagShield is constructed mu-metal (which blocks external MFs), allowing generation experimentally controlled MFs via 3-axial Helmholtz coils. Precise manipulation strengths across physiologically relevant range possible: nT hypomagnetic fields, μT < 1 mT weak MFs, moderate several mT. An integrated partition enables different control experimental run simultaneously. demonstrate (with example results) use

Язык: Английский

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