Background formation of lower levels of reactive oxygen species by neutrophils after hypomagnetic field exposure is not accompanied by the impairment of chemiluminescence response of neutrophils to respiratory-burst stimuli DOI
V. A. Novikov,

E. V. Yablokova,

I. A. Shaev

и другие.

Биофизика, Год журнала: 2023, Номер 68(6), С. 1180 - 1186

Опубликована: Дек. 15, 2023

Язык: Английский

Cellular and Molecular Effects of Magnetic Fields DOI Open Access
Maciej Tota,

Laura Jonderko,

Julia Witek

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8973 - 8973

Опубликована: Авг. 17, 2024

Recently, magnetic fields (MFs) have received major attention due to their potential therapeutic applications and biological effects. This review provides a comprehensive analysis of the cellular molecular impacts MFs, with focus on both in vitro vivo studies. We investigate mechanisms by which MFs influence cell behavior, including modifications gene expression, protein synthesis, signaling pathways. The interaction components such as ion channels, membranes, cytoskeleton is analyzed, along effects processes like proliferation, differentiation, apoptosis. Molecular insights are offered into how modulate oxidative stress inflammatory responses, pivotal various pathological conditions. Furthermore, we explore regenerative medicine, cancer treatment, neurodegenerative diseases. By synthesizing current findings, this article aims elucidate complex bioeffects thereby facilitating optimized application medical biotechnological fields.

Язык: Английский

Процитировано

7

The Radical Pair Mechanism Cannot Explain Telecommunication Frequency Effects on Reactive Oxygen Species DOI Creative Commons

Owaiss Talbi,

Hadi Zadeh‐Haghighi, Christoph Simon

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 25, 2024

ABSTRACT In order to investigate whether the radical pair mechanism (RPM) can explain effects of telecommunication frequency radiation on reactive oxygen species production, we modelled oscillating magnetic fields systems. Our analysis indicates that RPM cannot account for biological observed under exposure frequencies due negligible low-amplitude conditions used in experimental setups. Observable pairs at these would require hyperfine coupling constants are precisely fine-tuned large values far exceed those naturally occurring within We conclude some other must be responsible

Язык: Английский

Процитировано

3

Are Aminoglycoside Antibiotics TRPing Your Metabolic Switches? DOI Creative Commons
Alfredo Franco‐Obregón, Yee Kit Tai

Cells, Год журнала: 2024, Номер 13(15), С. 1273 - 1273

Опубликована: Июль 29, 2024

Transient receptor potential (TRP) channels are broadly implicated in the developmental programs of most tissues. Amongst these tissues, skeletal muscle and adipose noteworthy for being essential establishing systemic metabolic balance. TRP respond to environmental stimuli by supplying intracellular calcium that instigates enzymatic cascades consequence often impinge on mitochondrial function biogenesis. Critically, aminoglycoside antibiotics (AGAs) have been shown block capacity conduct entry into cell response a wide range biophysical nature, including mechanical, electromagnetic, thermal, chemical. Paradoxically, vitro paradigms commonly used understand organismal development may led astray conventional use streptomycin, an AGA, help prevent bacterial contamination. Accordingly, streptomycin has disrupt both vivo myogenesis, as well phenotypic switch white beige thermogenic status. In vivo, TRP-mediated calcium-dependent exercise adaptations importance metabolism. Alternatively, also curb detrimental levels leakage dystrophic through aberrantly gated TRPC1 be involved etiology X-linked muscular dystrophies. susceptible AGA antagonism critically modulating tissues that, if administered behaving animals, translate systemwide disruption. Regenerative medicine clinical communities need made aware this caveat usage seek viable alternatives, contamination or infection paradigms, respectively.

Язык: Английский

Процитировано

2

Radical pairs and superoxide amplification can explain magnetic field effects on planarian regeneration DOI Creative Commons
Rishabh Rishabh, Hadi Zadeh‐Haghighi, Christoph Simon

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 12, 2023

Abstract Weak magnetic field exposure can affect many biological processes across a wide range of living organisms. Recently, it has been observed that weak fields modulate reactive oxygen species (ROS) concentration, affecting regeneration in planaria. These effects show unusual nonlinear dependence on strength, including sign change. In another study by the same group, superoxide is identified as particular ROS being modulated. We propose radical pair mechanism based flavin-superoxide to explain modulation production and its effect planarian regeneration. The results our calculations favor triplet-born pair. Our yield reproduce dependence, Moreover, size we suggest simple amplification model inspired known biochemical mechanisms lay out conditions for such work. Further, also make empirical predictions concerning hypomagnetic

Язык: Английский

Процитировано

2

Verification of radical pair mechanism predictions for weak magnetic field effects on superoxide in planarians DOI Creative Commons
Rishabh Rishabh,

Jana Vučković,

Hadi Zadeh‐Haghighi

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

Superoxide concentration and tissue regeneration in planarians exhibit a complex non-monotonic dependence on the strength of an applied weak magnetic field. While this is difficult to understand based classical physics, recently proposed quantum model flavinsuperoxide radical pair mechanism could replicate previously observed superoxide concentrations. However, also predicts increased concentrations for both lower higher fields. This seemed conflict with earlier experimental observations blastema sizes, which were correlated regime but known not follow predicted trends Motivated by apparent contradiction, we here directly experimentally tested predictions To our own surprise, experiments confirmed superoxide, incorporating interactions multiple nuclei further improved model's agreement data. open questions remain regarding exact relationship between sizes revealed be more than observed, detailed properties underlying pair, results significantly support biological explanation field effects.

Язык: Английский

Процитировано

0

The radical pair mechanism of biological effects on hypomagnetic fields and one method to verify it DOI Open Access

Ouyang Jin-hua

Journal of Life Sciences Research, Год журнала: 2023, Номер 10(1), С. 1 - 7

Опубликована: Авг. 30, 2023

The biological effects due to a hypomagnetic field (HMF) is very important subject not only for aerospace traveling and space station living but also some magnetic shielding conditions on the ground just like underground bunkers etc. However, my knowledge, mechanisms which can be related of HMF remain unclear. In this study, I firstly summary one radical pair mechanism based present researches, then propose how prove mechanism’s truth in through experiments. way give relation between singlet yield angle describing orientation basis hyperfine tensor electron spin nuclei possible hand, crucial method that changed causes vivo or vitro disprove other because with angle, easy controlled

Язык: Английский

Процитировано

0

Hypomagnetické polia a ich vplyv na bunkové kultúry DOI Creative Commons
Marek Bajtoš, Roman Radil,

Monika Štefaňáková

и другие.

Опубликована: Янв. 1, 2023

Hypomagnetické polia, alebo takmer nulové magnetické polia sú s hodnotou amplitúdy magnetickej indukcie nižšou ako geomagnetické pole Zeme.Účinky týchto tzv, slabých magnetických polí sa u živých organizmov môžu prejavovať ovplyvnením biologických

Процитировано

0

A Decrease in the Background Production of Reactive Oxygen Species by Neutrophils after the Action of Hypomagnetic Field Is Not Accompanied by a Violation of Their Chemiluminescent Response to Respiratory Burst Activators DOI
V. A. Novikov,

E. V. Yablokova,

I. A. Shaev

и другие.

BIOPHYSICS, Год журнала: 2023, Номер 68(6), С. 978 - 983

Опубликована: Дек. 1, 2023

Язык: Английский

Процитировано

0

Background formation of lower levels of reactive oxygen species by neutrophils after hypomagnetic field exposure is not accompanied by the impairment of chemiluminescence response of neutrophils to respiratory-burst stimuli DOI
V. A. Novikov,

E. V. Yablokova,

I. A. Shaev

и другие.

Биофизика, Год журнала: 2023, Номер 68(6), С. 1180 - 1186

Опубликована: Дек. 15, 2023

Язык: Английский

Процитировано

0