Биофизика, Год журнала: 2023, Номер 68(6), С. 1180 - 1186
Опубликована: Дек. 15, 2023
Язык: Английский
Биофизика, Год журнала: 2023, Номер 68(6), С. 1180 - 1186
Опубликована: Дек. 15, 2023
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8973 - 8973
Опубликована: Авг. 17, 2024
Recently, magnetic fields (MFs) have received major attention due to their potential therapeutic applications and biological effects. This review provides a comprehensive analysis of the cellular molecular impacts MFs, with focus on both in vitro vivo studies. We investigate mechanisms by which MFs influence cell behavior, including modifications gene expression, protein synthesis, signaling pathways. The interaction components such as ion channels, membranes, cytoskeleton is analyzed, along effects processes like proliferation, differentiation, apoptosis. Molecular insights are offered into how modulate oxidative stress inflammatory responses, pivotal various pathological conditions. Furthermore, we explore regenerative medicine, cancer treatment, neurodegenerative diseases. By synthesizing current findings, this article aims elucidate complex bioeffects thereby facilitating optimized application medical biotechnological fields.
Язык: Английский
Процитировано
7bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июнь 25, 2024
ABSTRACT In order to investigate whether the radical pair mechanism (RPM) can explain effects of telecommunication frequency radiation on reactive oxygen species production, we modelled oscillating magnetic fields systems. Our analysis indicates that RPM cannot account for biological observed under exposure frequencies due negligible low-amplitude conditions used in experimental setups. Observable pairs at these would require hyperfine coupling constants are precisely fine-tuned large values far exceed those naturally occurring within We conclude some other must be responsible
Язык: Английский
Процитировано
3Cells, Год журнала: 2024, Номер 13(15), С. 1273 - 1273
Опубликована: Июль 29, 2024
Transient receptor potential (TRP) channels are broadly implicated in the developmental programs of most tissues. Amongst these tissues, skeletal muscle and adipose noteworthy for being essential establishing systemic metabolic balance. TRP respond to environmental stimuli by supplying intracellular calcium that instigates enzymatic cascades consequence often impinge on mitochondrial function biogenesis. Critically, aminoglycoside antibiotics (AGAs) have been shown block capacity conduct entry into cell response a wide range biophysical nature, including mechanical, electromagnetic, thermal, chemical. Paradoxically, vitro paradigms commonly used understand organismal development may led astray conventional use streptomycin, an AGA, help prevent bacterial contamination. Accordingly, streptomycin has disrupt both vivo myogenesis, as well phenotypic switch white beige thermogenic status. In vivo, TRP-mediated calcium-dependent exercise adaptations importance metabolism. Alternatively, also curb detrimental levels leakage dystrophic through aberrantly gated TRPC1 be involved etiology X-linked muscular dystrophies. susceptible AGA antagonism critically modulating tissues that, if administered behaving animals, translate systemwide disruption. Regenerative medicine clinical communities need made aware this caveat usage seek viable alternatives, contamination or infection paradigms, respectively.
Язык: Английский
Процитировано
2bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Дек. 12, 2023
Abstract Weak magnetic field exposure can affect many biological processes across a wide range of living organisms. Recently, it has been observed that weak fields modulate reactive oxygen species (ROS) concentration, affecting regeneration in planaria. These effects show unusual nonlinear dependence on strength, including sign change. In another study by the same group, superoxide is identified as particular ROS being modulated. We propose radical pair mechanism based flavin-superoxide to explain modulation production and its effect planarian regeneration. The results our calculations favor triplet-born pair. Our yield reproduce dependence, Moreover, size we suggest simple amplification model inspired known biochemical mechanisms lay out conditions for such work. Further, also make empirical predictions concerning hypomagnetic
Язык: Английский
Процитировано
2bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 21, 2024
Superoxide concentration and tissue regeneration in planarians exhibit a complex non-monotonic dependence on the strength of an applied weak magnetic field. While this is difficult to understand based classical physics, recently proposed quantum model flavinsuperoxide radical pair mechanism could replicate previously observed superoxide concentrations. However, also predicts increased concentrations for both lower higher fields. This seemed conflict with earlier experimental observations blastema sizes, which were correlated regime but known not follow predicted trends Motivated by apparent contradiction, we here directly experimentally tested predictions To our own surprise, experiments confirmed superoxide, incorporating interactions multiple nuclei further improved model's agreement data. open questions remain regarding exact relationship between sizes revealed be more than observed, detailed properties underlying pair, results significantly support biological explanation field effects.
Язык: Английский
Процитировано
0Journal of Life Sciences Research, Год журнала: 2023, Номер 10(1), С. 1 - 7
Опубликована: Авг. 30, 2023
The biological effects due to a hypomagnetic field (HMF) is very important subject not only for aerospace traveling and space station living but also some magnetic shielding conditions on the ground just like underground bunkers etc. However, my knowledge, mechanisms which can be related of HMF remain unclear. In this study, I firstly summary one radical pair mechanism based present researches, then propose how prove mechanism’s truth in through experiments. way give relation between singlet yield angle describing orientation basis hyperfine tensor electron spin nuclei possible hand, crucial method that changed causes vivo or vitro disprove other because with angle, easy controlled
Язык: Английский
Процитировано
0Опубликована: Янв. 1, 2023
Hypomagnetické polia, alebo takmer nulové magnetické polia sú s hodnotou amplitúdy magnetickej indukcie nižšou ako geomagnetické pole Zeme.Účinky týchto tzv, slabých magnetických polí sa u živých organizmov môžu prejavovať ovplyvnením biologických
Процитировано
0BIOPHYSICS, Год журнала: 2023, Номер 68(6), С. 978 - 983
Опубликована: Дек. 1, 2023
Язык: Английский
Процитировано
0Биофизика, Год журнала: 2023, Номер 68(6), С. 1180 - 1186
Опубликована: Дек. 15, 2023
Язык: Английский
Процитировано
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