Cellular and Molecular Effects of Magnetic Fields
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8973 - 8973
Опубликована: Авг. 17, 2024
Recently,
magnetic
fields
(MFs)
have
received
major
attention
due
to
their
potential
therapeutic
applications
and
biological
effects.
This
review
provides
a
comprehensive
analysis
of
the
cellular
molecular
impacts
MFs,
with
focus
on
both
in
vitro
vivo
studies.
We
investigate
mechanisms
by
which
MFs
influence
cell
behavior,
including
modifications
gene
expression,
protein
synthesis,
signaling
pathways.
The
interaction
components
such
as
ion
channels,
membranes,
cytoskeleton
is
analyzed,
along
effects
processes
like
proliferation,
differentiation,
apoptosis.
Molecular
insights
are
offered
into
how
modulate
oxidative
stress
inflammatory
responses,
pivotal
various
pathological
conditions.
Furthermore,
we
explore
regenerative
medicine,
cancer
treatment,
neurodegenerative
diseases.
By
synthesizing
current
findings,
this
article
aims
elucidate
complex
bioeffects
thereby
facilitating
optimized
application
medical
biotechnological
fields.
Язык: Английский
The Radical Pair Mechanism Cannot Explain Telecommunication Frequency Effects on Reactive Oxygen Species
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 25, 2024
ABSTRACT
In
order
to
investigate
whether
the
radical
pair
mechanism
(RPM)
can
explain
effects
of
telecommunication
frequency
radiation
on
reactive
oxygen
species
production,
we
modelled
oscillating
magnetic
fields
systems.
Our
analysis
indicates
that
RPM
cannot
account
for
biological
observed
under
exposure
frequencies
due
negligible
low-amplitude
conditions
used
in
experimental
setups.
Observable
pairs
at
these
would
require
hyperfine
coupling
constants
are
precisely
fine-tuned
large
values
far
exceed
those
naturally
occurring
within
We
conclude
some
other
must
be
responsible
Язык: Английский
Are Aminoglycoside Antibiotics TRPing Your Metabolic Switches?
Cells,
Год журнала:
2024,
Номер
13(15), С. 1273 - 1273
Опубликована: Июль 29, 2024
Transient
receptor
potential
(TRP)
channels
are
broadly
implicated
in
the
developmental
programs
of
most
tissues.
Amongst
these
tissues,
skeletal
muscle
and
adipose
noteworthy
for
being
essential
establishing
systemic
metabolic
balance.
TRP
respond
to
environmental
stimuli
by
supplying
intracellular
calcium
that
instigates
enzymatic
cascades
consequence
often
impinge
on
mitochondrial
function
biogenesis.
Critically,
aminoglycoside
antibiotics
(AGAs)
have
been
shown
block
capacity
conduct
entry
into
cell
response
a
wide
range
biophysical
nature,
including
mechanical,
electromagnetic,
thermal,
chemical.
Paradoxically,
vitro
paradigms
commonly
used
understand
organismal
development
may
led
astray
conventional
use
streptomycin,
an
AGA,
help
prevent
bacterial
contamination.
Accordingly,
streptomycin
has
disrupt
both
vivo
myogenesis,
as
well
phenotypic
switch
white
beige
thermogenic
status.
In
vivo,
TRP-mediated
calcium-dependent
exercise
adaptations
importance
metabolism.
Alternatively,
also
curb
detrimental
levels
leakage
dystrophic
through
aberrantly
gated
TRPC1
be
involved
etiology
X-linked
muscular
dystrophies.
susceptible
AGA
antagonism
critically
modulating
tissues
that,
if
administered
behaving
animals,
translate
systemwide
disruption.
Regenerative
medicine
clinical
communities
need
made
aware
this
caveat
usage
seek
viable
alternatives,
contamination
or
infection
paradigms,
respectively.
Язык: Английский
Radical pairs and superoxide amplification can explain magnetic field effects on planarian regeneration
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 12, 2023
Abstract
Weak
magnetic
field
exposure
can
affect
many
biological
processes
across
a
wide
range
of
living
organisms.
Recently,
it
has
been
observed
that
weak
fields
modulate
reactive
oxygen
species
(ROS)
concentration,
affecting
regeneration
in
planaria.
These
effects
show
unusual
nonlinear
dependence
on
strength,
including
sign
change.
In
another
study
by
the
same
group,
superoxide
is
identified
as
particular
ROS
being
modulated.
We
propose
radical
pair
mechanism
based
flavin-superoxide
to
explain
modulation
production
and
its
effect
planarian
regeneration.
The
results
our
calculations
favor
triplet-born
pair.
Our
yield
reproduce
dependence,
Moreover,
size
we
suggest
simple
amplification
model
inspired
known
biochemical
mechanisms
lay
out
conditions
for
such
work.
Further,
also
make
empirical
predictions
concerning
hypomagnetic
Язык: Английский
Verification of radical pair mechanism predictions for weak magnetic field effects on superoxide in planarians
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Superoxide
concentration
and
tissue
regeneration
in
planarians
exhibit
a
complex
non-monotonic
dependence
on
the
strength
of
an
applied
weak
magnetic
field.
While
this
is
difficult
to
understand
based
classical
physics,
recently
proposed
quantum
model
flavinsuperoxide
radical
pair
mechanism
could
replicate
previously
observed
superoxide
concentrations.
However,
also
predicts
increased
concentrations
for
both
lower
higher
fields.
This
seemed
conflict
with
earlier
experimental
observations
blastema
sizes,
which
were
correlated
regime
but
known
not
follow
predicted
trends
Motivated
by
apparent
contradiction,
we
here
directly
experimentally
tested
predictions
To
our
own
surprise,
experiments
confirmed
superoxide,
incorporating
interactions
multiple
nuclei
further
improved
model's
agreement
data.
open
questions
remain
regarding
exact
relationship
between
sizes
revealed
be
more
than
observed,
detailed
properties
underlying
pair,
results
significantly
support
biological
explanation
field
effects.
Язык: Английский
The radical pair mechanism of biological effects on hypomagnetic fields and one method to verify it
Journal of Life Sciences Research,
Год журнала:
2023,
Номер
10(1), С. 1 - 7
Опубликована: Авг. 30, 2023
The
biological
effects
due
to
a
hypomagnetic
field
(HMF)
is
very
important
subject
not
only
for
aerospace
traveling
and
space
station
living
but
also
some
magnetic
shielding
conditions
on
the
ground
just
like
underground
bunkers
etc.
However,
my
knowledge,
mechanisms
which
can
be
related
of
HMF
remain
unclear.
In
this
study,
I
firstly
summary
one
radical
pair
mechanism
based
present
researches,
then
propose
how
prove
mechanism’s
truth
in
through
experiments.
way
give
relation
between
singlet
yield
angle
describing
orientation
basis
hyperfine
tensor
electron
spin
nuclei
possible
hand,
crucial
method
that
changed
causes
vivo
or
vitro
disprove
other
because
with
angle,
easy
controlled
Язык: Английский
Hypomagnetické polia a ich vplyv na bunkové kultúry
Опубликована: Янв. 1, 2023
Hypomagnetické
polia,
alebo
takmer
nulové
magnetické
polia
sú
s
hodnotou
amplitúdy
magnetickej
indukcie
nižšou
ako
geomagnetické
pole
Zeme.Účinky
týchto
tzv,
slabých
magnetických
polí
sa
u
živých
organizmov
môžu
prejavovať
ovplyvnením
biologických
A Decrease in the Background Production of Reactive Oxygen Species by Neutrophils after the Action of Hypomagnetic Field Is Not Accompanied by a Violation of Their Chemiluminescent Response to Respiratory Burst Activators
BIOPHYSICS,
Год журнала:
2023,
Номер
68(6), С. 978 - 983
Опубликована: Дек. 1, 2023
Язык: Английский
Background formation of lower levels of reactive oxygen species by neutrophils after hypomagnetic field exposure is not accompanied by the impairment of chemiluminescence response of neutrophils to respiratory-burst stimuli
Биофизика,
Год журнала:
2023,
Номер
68(6), С. 1180 - 1186
Опубликована: Дек. 15, 2023
Язык: Английский