Cytokine, Год журнала: 2024, Номер 182, С. 156715 - 156715
Опубликована: Июль 27, 2024
Язык: Английский
Inflammation, Год журнала: 2022, Номер 45(6), С. 2091 - 2123
Опубликована: Май 19, 2022
Язык: Английский
Процитировано
85
Nutrients, Год журнала: 2022, Номер 14(6), С. 1305 - 1305
Опубликована: Март 20, 2022
At the beginning of coronavirus disease (COVID-19) pandemic, global efforts focused on containing spread virus and avoiding contagion. Currently, it is evident that health professionals should deal with overall status COVID-19 survivors. Indeed, novel findings have identified post-COVID-19 syndrome, which characterized by malnutrition, loss fat-free mass, low-grade inflammation. In addition, recovery might be complicated persistent functional impairment (i.e., fatigue muscle weakness, dysphagia, appetite loss, taste/smell alterations) as well psychological distress. Therefore, appropriate evaluation nutritional (assessment dietary intake, anthropometrics, body composition) one pillars in management these patients. On other hand, personalized recommendations represent best strategy to ensure recovery. this review aimed collect available evidence role nutrients their supplementation syndrome provide a practical guideline nutritionists tailor interventions for patients recovering from infections.
Язык: Английский
Процитировано
71
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 8034 - 8034
Опубликована: Апрель 28, 2023
Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities. The present lack of effective treatments makes managing long COVID a major challenge. One the underlying mechanisms be mitochondrial dysfunction. Severe acute respiratory syndrome 2 (SARS-CoV-2) infections can alter mitochondria responsible for energy production in cells. This alteration leads to dysfunction which, turn, increases oxidative stress. Ultimately, this results loss integrity and cell death. Moreover, viral proteins bind complexes, disrupting function causing immune cells over-react. over-reaction inflammation potentially symptoms. It is important note that roles damage inflammatory responses caused by SARS-CoV-2 development are still being elucidated. Targeting provide promising new clinical approaches long-COVID patients; however, further studies needed evaluate safety efficacy such approaches.
Язык: Английский
Процитировано
47
Molecular and Cellular Biochemistry, Год журнала: 2022, Номер 478(6), С. 1325 - 1343
Опубликована: Окт. 29, 2022
SARS-CoV-2 is a positive-strand RNA virus that infects humans through the nasopharyngeal and oral route causing COVID-19. Scientists left no stone unturned to explore targetable key player in COVID-19 pathogenesis against which therapeutic interventions can be initiated. This article has attempted review, coordinate accumulate most recent observations support of hypothesis predicting altered state mitochondria concerning mitochondrial redox homeostasis, inflammatory regulations, morphology, bioenergetics antiviral signalling infection. Mitochondria extremely susceptible physiological as well pathological stimuli, including viral infections. Recent studies suggest pathogeneses alter integrity, turn modulate cellular response M protein inhibited (MAVS) aggregation hinders innate response. Viral open reading frames (ORFs) also play an instrumental role altering regulation immune Notably, ORF-9b ORF-6 impair MAVS activation. In aged persons, NLRP3 inflammasome over-activated due impaired function, increased reactive oxygen species (mtROS), and/or circulating free DNA, resulting hyper-response classically activated macrophages. tries understand how fission–fusion dynamics affected by virus. review comprehends overall attribute prognosis patients infected with taking into account pertinent vitro, pre-clinical clinical data encompassing subjects broad range severity morbidity. endeavour may help exploring novel non-canonical strategies disease associated complications.
Язык: Английский
Процитировано
45
Annual Review of Immunology, Год журнала: 2024, Номер 42(1), С. 207 - 233
Опубликована: Янв. 12, 2024
The immune system and the kidneys are closely related. Immune components mediate acute kidney disease crucial to progression of chronic disease. Beyond its pathogenic functions, supports immunological homeostasis in healthy kidneys. help maintain equilibrium by removing metabolic waste products toxins, thereby limiting local systemic inflammation. In this review, we describe close relationship between We discuss how imbalance response can be deleterious immunomodulation important preventing end-stage renal addition, recent tools such as silico platforms organoids unveil cells homeostasis.
Язык: Английский
Процитировано
10
Nature Communications, Год журнала: 2022, Номер 13(1)
Опубликована: Июль 15, 2022
Cardiac involvement has been noted in COVID-19 infection. However, the relationship between post-recovery and development of de novo heart failure not investigated a large, nationally representative population. We examined outcomes 587,330 patients hospitalized United States (257,075 with 330,255 without), using data from National COVID Cohort Collaborative study. Patients were older (51 vs. 46 years), more often male (49% 42%), less White (61% 69%). Over median follow up 367 days, 10,979 incident events occurred. After adjustments, hospitalization was associated 45% higher hazard (hazard ratio = 1.45; 95% confidence interval: 1.39-1.51), pronounced associations among who younger (P-interaction 0.003), 0.005), or had established cardiovascular disease 0.005). In conclusion, is increased risk failure.
Язык: Английский
Процитировано
34
Metabolites, Год журнала: 2022, Номер 12(10), С. 912 - 912
Опубликована: Сен. 27, 2022
Increasing numbers of patients who recover from COVID-19 report lasting symptoms, such as fatigue, muscle weakness, dementia, and insomnia, known collectively post-acute COVID syndrome or long COVID. These symptoms have been examined in different studies found to influence multiple organs, sometimes resulting life-threating conditions. In this review, these are discussed connection the long-COVID-19 immune changes, highlighting oral psychiatric health, work focuses on gut microbiota’s link manifestations liver, heart, kidney, brain, spleen. A model is presented show biological clinical implications microbiota SARS-CoV-2 infection how they could possibly affect therapeutic aspects disease. Probiotics can support body’s systems fighting viral infections. This review current knowledge about use probiotics adjuvant therapies for that might help prevent complications.
Язык: Английский
Процитировано
32
Cells, Год журнала: 2021, Номер 10(7), С. 1762 - 1762
Опубликована: Июль 12, 2021
MicroRNAs (miRNAs) are critical regulators of gene expression that may be used to identify the pathological pathways influenced by disease and cellular interactions. Viral miRNAs (v-miRNAs) encoded both DNA RNA viruses induce immune dysregulation, virus production, pathogenesis. Given absence effective treatment prevalence highly infective SARS-CoV-2 strains, improved understanding viral-associated could provide novel mechanistic insights into pathogenesis COVID-19. In this study, v-miRNAs were identified deep sequencing in infected Calu-3 Vero E6 cell lines. Among ~0.1% small sequences mapped genome, top ten (including three N gene; v-miRNA-N) selected. After initial screening conserved v-miRNA-N-28612, which was SARS-CoV SARS-CoV-2, its shown positively associated with viral load COVID-19 patients. Further silico analysis synthetic-mimic transfection validated revealed functional targets associations mechanisms metabolism biosynthesis. Our findings support development v-miRNA-based biomarkers therapeutic strategies based on pathophysiology
Язык: Английский
Процитировано
38
Journal of Proteome Research, Год журнала: 2021, Номер 20(10), С. 4667 - 4680
Опубликована: Авг. 11, 2021
Severe coronavirus disease 2019 (COVID-19) infection may lead to lung injury, multi-organ failure, and eventually death. Cytokine storm due excess cytokine production has been associated with fatality in severe infections. However, the specific molecular signatures elevated immune response are yet be elucidated. We performed a mass-spectrometry-based proteomic metabolomic analysis of COVID-19 plasma samples collected at two time points. Using Orbitrap Fusion LC–MS/MS-based label-free analysis, we identified around 10 significant proteins, 32 peptides, 5 metabolites that were dysregulated Few these proteins by quantitative proteomics validated using multiple reaction monitoring (MRM) assay. Integrated pathway distinct revealed alterations complement coagulation cascade, platelet aggregation, myeloid leukocyte activation pathway, arginine metabolism. Further, highlight role metabolism pathogenesis targeting pathways for therapeutics.
Язык: Английский
Процитировано
34
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(13), С. 6862 - 6862
Опубликована: Июнь 25, 2021
Metabolic syndrome (MetS) is a well-defined yet difficult-to-manage disease entity. Both the precipitous rise in its incidence due to contemporary lifestyles and growing heterogeneity among affected populations present unprecedented challenges. Moreover, predisposed risk for developing severe acute respiratory coronavirus 2 (SARS-CoV-2) infection with MetS, viral impacts on host metabolic parameters, underscores need investigate this mechanism thoroughly. Recent investigations of metabolomics proteomics have revealed not only differentially expressed substances but also consequences diet consumption physical activity energy metabolism. These variations metabolites, as well protein products, influence wide spectrum characteristics, from cellular behavior phenotype. Research dysregulation gut microbiota resultant inflammatory status has contributed our understanding underlying pathogenic mechanisms. As state-of-the-art therapies, advancing depictions bio-molecular landscape MetS emerged now play key role individualized precision medicine. Fecal transplantation, aiming restore host’s homeostasis, targeting bile acid signaling pathway are two approaches combatting MetS. Comprehensive molecular inquiries about by omics measures mandatory facilitate development novel therapeutic modalities.
Язык: Английский
Процитировано
28