Integrated Transcriptomic Analysis Reveals Reciprocal Interactions between SARS-CoV-2 Infection and Multi-Organ Dysfunction, Especially the Correlation of Renal Failure and COVID-19

Life, Год журнала: 2024, Номер 14(8), С. 960 - 960

Опубликована: Июль 30, 2024

The COVID-19 pandemic, which is caused by the SARS-CoV-2 virus, has resulted in extensive health challenges globally. While primarily targets respiratory system, clinical studies have revealed that it could also affect multiple organs, including heart, kidneys, liver, and brain, leading to severe complications. To unravel intricate molecular interactions between virus host tissues, we performed an integrated transcriptomic analysis investigate effects of on various with a particular focus relationship renal failure COVID-19. A comparative showed triggers systemic immune response kidney characterized significant upregulation cytokine chemokine secretion, along enhanced migration lymphocytes leukocytes. weighted gene co-expression network demonstrated induce tissue-specific transcriptional profiling. More importantly, single-cell sequencing patients exhibited lower metabolic activity lung epithelial B cells, reduced ligand-receptor interactions, especially CD226 ICAM, suggesting compromised response. trajectory less mature alveolar type 1 cells. Furthermore, these potential fibrosis hearts, increased extracellular matrix remodeling activities. However, there was no dysregulation liver failure. Candidate drugs prediction Drug Signatures database LINCS L1000 Antibody Perturbations Database underscored importance considering multi-organ management highlight therapeutic strategies, targeting viral entry replication, controlling tissue fibrosis, alleviating inflammation.

Язык: Английский

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Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Авг. 9, 2024

Chronic kidney disease presents global health challenges, with hemodialysis as a common treatment. However, non-dialyzable uremic toxins demand further investigation for new therapeutic approaches. Renal tubular cells require scrutiny due to their vulnerability toxins.

Язык: Английский

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Circulating Microparticles in the Pathogenesis and Early Anticoagulation of Thrombosis in COVID-19 With Kidney Injury

Frontiers in Cell and Developmental Biology, Год журнала: 2022, Номер 9

Опубликована: Янв. 18, 2022

As more is learned about the pathophysiological mechanisms of COVID-19, systemic thrombosis has been recognized as being associated with severe clinical manifestations, mortality and sequelae. many 40% patients admitted to hospital due COVID-19 have acute kidney injury, coagulation abnormalities main cause impaired function. However, mechanism renal process leading injury are unclear. Microparticles (MPs) membrane bubbles released in response activation, or apoptosis cells. The phosphatidylserine (PS) exposed on surface MPs provides binding sites for endogenous exogenous FXase complexes prothrombin complexes, thus providing a platform cascade reaction facilitating clot formation. In context infection, viral attack leads immune cells release cytokines that damage circulating blood vascular endothelial cells, resulting increased levels. Therefore, can be used risk factor predict microthrombosis injury. this paper, we summarized latest data treatment caused by revealing abnormality MP PS storms universal progression aggravates sequelae potentially other pandemic diseases. This paper also describes factors affecting from perspective Virchow's triad: hypercoagulability, decreased flow velocity. summary, given serious consequences thrombosis, current guidelines studies suggest early prophylactic anticoagulant therapy reduces improves outcomes. Early anticoagulation, through inhibition PS-mediated coagulopathy, allows maintenance unobstructed circulation oxygen delivery thereby removal inflammatory factors, viruses, MPs, dead damaged expediting patient rehabilitation.

Язык: Английский

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Association of COVID-19 with hepatic metabolic dysfunction

World Journal of Virology, Год журнала: 2022, Номер 11(5), С. 237 - 251

Опубликована: Сен. 24, 2022

The coronavirus disease 2019 (COVID-19) pandemic continues to be a global problem with over 438 million cases reported so far. Although it mostly affects the respiratory system, involvement of extrapulmonary organs, including liver, is not uncommon. Since beginning pandemic, metabolic com-orbidities, such as obesity, diabetes, hypertension, and dyslipidemia, have been identified poor prognostic indicators. Subsequent lipidomic studies several dysfunctions in patients COVID-19. alterations appear linked course inflammatory reaction body. liver an important organ high activity, significant proportion COVID-19 comorbidities; thus, this factor could play key role orchestrating systemic changes during infection. Evidence suggests that dysregulation has both short- long-term implications. Furthermore, adverse associations metabolic-associated fatty disease. Due ensuing effects on renin-angiotensin-aldosterone system ammonia metabolism, can implications advanced chronic A thorough understanding COVID-19-associated dysfunction lead identification plasma biomarkers novel treatment targets. In review, we discuss current COVID-19, focusing exploring underlying mechanistic pathogenesis clinical

Язык: Английский

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Immuno-inflammatory and organ dysfunction markers in severe COVID-19 patients

Cytokine, Год журнала: 2024, Номер 182, С. 156715 - 156715

Опубликована: Июль 27, 2024

Язык: Английский

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