Assessment of cerebrovascular function in patients with sickle cell disease using transfer function analysis
Physiological Reports,
Год журнала:
2022,
Номер
10(19)
Опубликована: Окт. 1, 2022
In
patients
with
sickle
cell
disease
(SCD),
the
delivery
of
oxygen
to
brain
is
compromised
by
anemia,
abnormal
rheology,
and
steno-occlusive
vascular
disease.
Successful
compensation
depends
on
an
increase
in
supply
such
as
that
provided
cerebral
blood
flow
(CBF).
We
used
magnetic
resonance
imaging
provide
a
high-resolution
assessment
ability
SCD
respond
vasoactive
stimulus
middle,
anterior,
posterior
artery
territories
for
both
white
gray
matter.
Cerebrovascular
reactivity
(CVR)
was
measured
level
dependent
signal
(a
surrogate
CBF)
response
end
tidal
partial
pressure
CO
Язык: Английский
Determining the effects of elevated partial pressure of oxygen on hypercapnia-induced cerebrovascular reactivity
Journal of Cerebral Blood Flow & Metabolism,
Год журнала:
2023,
Номер
43(12), С. 2085 - 2095
Опубликована: Авг. 26, 2023
Evaluation
of
cerebrovascular
reactivity
(CVR)
to
hypo-
and
hypercapnia
is
a
valuable
test
for
the
assessment
vasodilatory
reserve.
While
hypercapnia-induced
CVR
testing
usually
performed
at
normoxia,
mild
hyperoxia
may
increase
tolerability
by
reducing
ventilatory
distress.
However,
effects
on
was
unknown.
We
therefore
recruited
21
patients
with
range
steno-occlusive
diseases
12
healthy
participants
who
underwent
standardized
13-minute
step
plus
ramp
carbon
dioxide
gas
challenge
subject’s
resting
end-tidal
partial
pressure
oxygen
or
(PetO
2
=
150
mmHg)
depending
which
group
they
were
assigned.
In
11
patients,
second
normoxia
examine
test-retest
differences.
defined
as
%
Δ
Signal/ΔPetCO
.
found
that
there
no
significant
difference
between
results
conducted
in
Groups
1
portion.
also
retest
pathology
(Group
3)
concluded
normoxic
repeatable,
does
not
affect
CVR.
Язык: Английский
Impaired cerebrovascular reactivity in pediatric sickle cell disease using diffuse correlation spectroscopy
Biomedical Optics Express,
Год журнала:
2023,
Номер
14(11), С. 5696 - 5696
Опубликована: Сен. 29, 2023
Cerebrovascular
reactivity
(CVR),
defined
as
the
ability
of
cerebral
vasculature
to
dilate
in
response
a
vasodilatory
stimulus,
is
an
integral
mechanism
brain
homeostasis
that
thought
be
impaired
sickle
cell
disease
(SCD).
This
study
used
diffuse
correlation
spectroscopy
and
simple
breath-hold
stimulus
quantify
CVR
non-invasively
cohort
12
children
with
SCD
14
controls.
Median
[interquartile
range]
was
significantly
decreased
compared
controls
(2.03
[1.31,
2.44]
versus
3.49
[3.00,
4.11]
%/mmHg,
p
=
0.028).
These
results
suggest
DCS
may
provide
feasible
means
routinely
monitor
impairments
pediatric
SCD.
Язык: Английский