Impaired cerebrovascular reactivity in pediatric sickle cell disease using diffuse correlation spectroscopy DOI Creative Commons
Kyle R. Cowdrick,

Mariam Akbar,

Tisha Boodooram

и другие.

Biomedical Optics Express, Год журнала: 2023, Номер 14(11), С. 5696 - 5696

Опубликована: Сен. 29, 2023

Cerebrovascular reactivity (CVR), defined as the ability of cerebral vasculature to dilate in response a vasodilatory stimulus, is an integral mechanism brain homeostasis that thought be impaired sickle cell disease (SCD). This study used diffuse correlation spectroscopy and simple breath-hold stimulus quantify CVR non-invasively cohort 12 children with SCD 14 controls. Median [interquartile range] was significantly decreased compared controls (2.03 [1.31, 2.44] versus 3.49 [3.00, 4.11] %/mmHg, p = 0.028). These results suggest DCS may provide feasible means routinely monitor impairments pediatric SCD.

Язык: Английский

Assessment of cerebrovascular function in patients with sickle cell disease using transfer function analysis DOI Creative Commons
Ece Su Sayin, Olivia Sobczyk, Julien Poublanc

и другие.

Physiological Reports, Год журнала: 2022, Номер 10(19)

Опубликована: Окт. 1, 2022

In patients with sickle cell disease (SCD), the delivery of oxygen to brain is compromised by anemia, abnormal rheology, and steno-occlusive vascular disease. Successful compensation depends on an increase in supply such as that provided cerebral blood flow (CBF). We used magnetic resonance imaging provide a high-resolution assessment ability SCD respond vasoactive stimulus middle, anterior, posterior artery territories for both white gray matter. Cerebrovascular reactivity (CVR) was measured level dependent signal (a surrogate CBF) response end tidal partial pressure CO

Язык: Английский

Процитировано

5

Determining the effects of elevated partial pressure of oxygen on hypercapnia-induced cerebrovascular reactivity DOI Creative Commons
Ece Su Sayin, James Duffin, Julien Poublanc

и другие.

Journal of Cerebral Blood Flow & Metabolism, Год журнала: 2023, Номер 43(12), С. 2085 - 2095

Опубликована: Авг. 26, 2023

Evaluation of cerebrovascular reactivity (CVR) to hypo- and hypercapnia is a valuable test for the assessment vasodilatory reserve. While hypercapnia-induced CVR testing usually performed at normoxia, mild hyperoxia may increase tolerability by reducing ventilatory distress. However, effects on was unknown. We therefore recruited 21 patients with range steno-occlusive diseases 12 healthy participants who underwent standardized 13-minute step plus ramp carbon dioxide gas challenge subject’s resting end-tidal partial pressure oxygen or (PetO 2 = 150 mmHg) depending which group they were assigned. In 11 patients, second normoxia examine test-retest differences. defined as % Δ Signal/ΔPetCO . found that there no significant difference between results conducted in Groups 1 portion. also retest pathology (Group 3) concluded normoxic repeatable, does not affect CVR.

Язык: Английский

Процитировано

2

Impaired cerebrovascular reactivity in pediatric sickle cell disease using diffuse correlation spectroscopy DOI Creative Commons
Kyle R. Cowdrick,

Mariam Akbar,

Tisha Boodooram

и другие.

Biomedical Optics Express, Год журнала: 2023, Номер 14(11), С. 5696 - 5696

Опубликована: Сен. 29, 2023

Cerebrovascular reactivity (CVR), defined as the ability of cerebral vasculature to dilate in response a vasodilatory stimulus, is an integral mechanism brain homeostasis that thought be impaired sickle cell disease (SCD). This study used diffuse correlation spectroscopy and simple breath-hold stimulus quantify CVR non-invasively cohort 12 children with SCD 14 controls. Median [interquartile range] was significantly decreased compared controls (2.03 [1.31, 2.44] versus 3.49 [3.00, 4.11] %/mmHg, p = 0.028). These results suggest DCS may provide feasible means routinely monitor impairments pediatric SCD.

Язык: Английский

Процитировано

1