Nourishing Physical Productivity and Performance On a Warming Planet - Challenges and Nutritional Strategies to Mitigate Exertional Heat Stress DOI Creative Commons
Alan J. McCubbin, Christopher Irwin, Ricardo J. S. Costa

и другие.

Current Nutrition Reports, Год журнала: 2024, Номер 13(3), С. 399 - 411

Опубликована: Июль 12, 2024

Abstract Purpose of Review Climate change is predicted to increase the frequency and severity exposure hot environments. This can impair health, physical performance, productivity for active individuals in occupational athletic settings. review summarizes current knowledge recent advancements nutritional strategies minimize impact exertional-heat stress (EHS). Recent Findings Hydration limiting body mass loss < 3% during EHS are performance-beneficial weight-supported activities, although evidence regarding smaller fluid deficits (< 2% loss) weight-dependent activities less clear due a lack well-designed studies with adequate blinding. Sodium replacement requirements depends on both sweat losses extent replacement, quantified sodium only necessary once > 60–80% losses. Ice ingestion lowers core temperature may improve thermal comfort performance outcomes when consumed before, but so activity. Prevention management gastrointestinal disturbances should focus high carbohydrate low FODMAP availability before exercise, frequent provision and/or protein hydration, regulation. Evidence these approaches lacking Acute kidney injury potential concern resulting from inadequate post-EHS, emerging suggests that repeated exposures risk developing chronic disease. Summary Nutritional help regulate temperature, status EHS. Doing minimizes health safety optimizes warming planet.

Язык: Английский

The Effects of Prebiotic Supplementation on Markers of Exercise-Induced Gastrointestinal Syndrome in Response to Exertional Heat Stress DOI
Christopher Rauch, Kayla Henningsen, Isabel G. Martinez

и другие.

International Journal of Sport Nutrition and Exercise Metabolism, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Янв. 1, 2025

Exercise perturbs various aspects of gastrointestinal integrity and function, which may lead to performance impeding symptoms (GIS) and/or precipitate clinical issues warranting medical management. This study aimed determine the impact prebiotic supplementation on functional status in response exertional heat stress (EHS). Sixteen endurance athletes completed two trials 3-hr running at 60% 30 °C baseline (T1) following an 8-week period (T2), with 16 g/day (PREBIOTIC) or matched placebo (PLACEBO). Blood samples were collected pre-EHS post-EHS recovery for determination (cortisol), intestinal epithelial injury (intestinal fatty acid binding protein), bacterial endotoxemia (sCD14), systemic inflammation (C-reactive protein). GIS feeding tolerance variables assessed throughout EHS. Orocecal transit time was determined via a lactulose challenge given 2.5 hr into Plasma cortisol (combined mean: +252 ng/ml), protein (+800 pg/ml), sCD14 (+487 ng/ml) concentrations increased EHS T1 ( p ≤ .05), but not C-reactive (+0.8 μg/ml; > both PREBIOTIC PLACEBO. resulted blunted T2 (+316 pg/ml) compared increase (+1,001 PLACEBO = .005). Lower observed (2,799 versus (3,246 only .039). No intervention effects protein. difference within between orocecal time, GIS, tolerance. In conclusion, 8 weeks modestly attenuates associated perturbations integrity, does further impair exacerbate

Язык: Английский

Процитировано

1
Effect of brief ambient cooling on serum stress biomarkers in older adults during a daylong heat exposure: a laboratory-based heat wave simulation DOI
Ben J. Lee, Robert D. Meade, Sarah Davey

и другие.

Applied Physiology Nutrition and Metabolism, Год журнала: 2025, Номер 50, С. 1 - 8

Опубликована: Янв. 1, 2025

Visiting an air-conditioned location during heat exposure reduces physiological strain; however, the effects on gastrointestinal barrier dysfunction and renal ischemia remain unexplored. We compared serum protein responses a 9 h (40.3 °C, 9.3% relative humidity) in 17 older adults without cooling (control) 19 with break (∼23 °C) hours 5 6 (cooling). IFABP sCD14 increased similarly across groups. NGAL was 3.2 pg/mL [1.9, 6.1] lower group exposure. A 2 centre did not ameliorate dysfunction, but reduce surrogate marker of ischemia. ClinicalTrials.gov identifier: NCT04353076.

Язык: Английский

Процитировано

1
The impact of 48 h high carbohydrate diets with high and low FODMAP content on gastrointestinal status and symptoms in response to endurance exercise, and subsequent endurance performance DOI
Rachel Scrivin, Gary Slater,

Alice Mika

и другие.

Applied Physiology Nutrition and Metabolism, Год журнала: 2024, Номер 49(6), С. 773 - 791

Опубликована: Фев. 15, 2024

This study investigated the effects of a high carbohydrate diet, with varied fermentable oligo-, di-, and mono-saccharide polyol (FODMAP) content, before endurance exercise on gastrointestinal integrity, motility, symptoms; subsequent performance. Twelve athletes were provided 48 h (mean ± SD: 12.1 1.8 g kg day

Язык: Английский

Процитировано

7
Exertional Stress-induced Pathogenic Luminal Content Translocation – Friend or Foe? DOI
Kayla Henningsen, Isabel G. Martinez, Ricardo J. S. Costa

и другие.

International Journal of Sports Medicine, Год журнала: 2024, Номер 45(08), С. 559 - 571

Опубликована: Янв. 29, 2024

Abstract The incidence of perturbed gastrointestinal integrity, as well resulting systemic immune responses and symptoms, otherwise known exercised-induced syndrome (EIGS), is common among individuals who partake in prolonged exercise. EIGS may cause the translocation pathogenic material, including whole bacteria bacterial endotoxins, from lumen into circulation, which progress clinical consequences such sepsis, potentially subsequent fatality. However, further investigation warranted to assess possibility food allergen and/or digestive enzyme luminal circulatory response exercise, consequences. Findings this narrative literature review demonstrate evidence that endotoxins circulation occurs exercise stress, with a greater propensity occurring accompanying heat exposure. It has also been demonstrated allergens can translocate stress initiate anaphylaxis. To date, no research investigating effect on enzymes exists. evident consequential presents life-threatening implications, warranting development implementation effective management strategies at-risk populations.

Язык: Английский

Процитировано

5
Does Age Influence Gastrointestinal Status Responses to Exertional-heat Stress? DOI
Pascale Young, Kayla Henningsen, Rhiannon M. J. Snipe

и другие.

International Journal of Sports Medicine, Год журнала: 2024, Номер 45(04), С. 272 - 281

Опубликована: Янв. 10, 2024

Abstract This meta-data exploration aimed to determine the impact of exertional-heat stress (EHS) on gastrointestinal status masters age and young adult endurance athletes. Sixteen MASTERS (mean: 44y) twenty-one YOUNG (26y) recreational athletes completed 2 h running at 60% ˙V O2max in 35˚C ambient conditions. Blood samples were collected pre-, immediately 1 post-EHS, analyzed for markers exercise-induced syndrome (EIGS). Thermo-physiological measures symptoms (GIS) recorded every 10–20 min during EHS. Peak Δ pre- post-EHS did not substantially differ (p>0.05) between intestinal epithelial injury [I-FABP: 1652pg/ml vs. 1524pg/ml, respectively], bacterial endotoxic translocation [sCD14: -0.09µg/mL 0.84µg/mL, lipopolysaccharide-binding protein [LBP: 0.26µg/mL 1.76µg/mL, systemic inflammatory response profile (SIR-Profile: 92.0arb.unit 154arb.unit, respectively). A significantly higher peak endogenous endotoxin anti-body IgM (p=0.042), pro-inflammatory cytokine IL-1β (p=0.038), was observed compared MASTERS. No difference incidence (81% 80%, respectively) severity (summative accumulation: 21 30, reported GIS EHS YOUNG. Pathophysiology EIGS does with progression, since younger responded comparably.

Язык: Английский

Процитировано

4
The Influence of Dietary Supplements on Exercise-Induced Gut Damage and Gastrointestinal Symptoms: A Systematic Review and Meta-Analysis DOI Open Access

Robyn Aitkenhead,

Mark Waldron, Gillian E. Conway

и другие.

Nutrients, Год журнала: 2025, Номер 17(3), С. 443 - 443

Опубликована: Янв. 25, 2025

Endurance exercise, especially under heat stress, temporarily compromises the integrity of intestinal barrier in healthy individuals. Consequently, there is growing interest developing effective dietary strategies to alleviate exercise-induced gastrointestinal symptoms and gut damage. This meta-analysis investigated effects supplements on mitigating these challenges. The search was performed November 2024 following PRISMA guidelines, 26 peer-reviewed studies were included across three meta-analyses: (1) symptoms, (2) circulating fatty acid-binding protein (i-FABP), (3) exercise performance. moderating effect variables assessed via sub-group analysis meta-regression. Overall, no pooled supplement interventions (Hedges’ g = 0.42, 95% CI −0.17: 1.02, p 0.15), probiotics had a moderate significant for −0.62, −1.01; 1.01, 0.05). There increase i-FABP concentrations pre- post (∆ 106%; Hedges’ 0.63; 1.38, 0.01). or differences performance any (p 0.53). Moderate-to-large heterogeneity observed (I2 ≥ 58.6%), candidate moderators (exercise duration, modality, environmental temperature) outcomes > A during observed. However, when examining different categories, although significance select few supplements, changes i-FABP, outside clinical relevance. Although showed conflicting findings may have been due inadequate control confounding studies. Further research required assess alternative supplements’ health performance, particularly varied conditions, where more rigorous cofounding factors implemented.

Язык: Английский

Процитировано

0
Sports Dietitians Australia and Ultra Sports Science Foundation Joint Position Statement: A Practitioner Guide to the Prevention and Management of Exercise-Associated Gastrointestinal Perturbations and Symptoms DOI Creative Commons
Ricardo J. S. Costa, Stephanie K. Gaskell, Kayla Henningsen

и другие.

Sports Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Язык: Английский

Процитировано

0
Exertional heat stress promotes the presence of bacterial DNA in plasma: A counterbalanced randomised controlled trial DOI Creative Commons
Kayla Henningsen, Rebekah Henry, Stephanie K. Gaskell

и другие.

Journal of science and medicine in sport, Год журнала: 2024, Номер 27(9), С. 610 - 617

Опубликована: Сен. 1, 2024

ObjectivesThe primary aim was to explore the impact of exertional-heat stress (EHS) promoted exercise-associated bacteraemia. A secondary examine if an amino acid beverage (AAB) intervention may mitigate bacteraemia.DesignCounterbalanced randomised control trial.MethodsTwenty endurance trained male participants completed two EHS trials. On one occasion, consumed a 237 mL AAB twice daily for 7-days prior, immediately before and every 20 min during (2 h running at 60 % V̇O2max in 35 °C). other water volume (CON) equivalent consumed. Whole blood samples were collected pre- post-EHS, analysed plasma DNA concentration by fluorometer quantification after microbial extraction, bacterial relative abundance next generation 16 s rRNA gene sequencing.ResultsIncreased post-EHS observed on CON (pre-EHS 0.014 ng/μL, 0.039 ng/μL) (p < 0.001) 0.015 0.031 0.001). The magnitude change from post-exercise 40 lower, but no significant difference versus = 0.455). Predominant groups identified included: phyla-Proteobacteria (88.0 %), family-Burkholderiaceae (59.1 genus-Curvibacter (58.6 %). No variation absolute α-diversity phyla, family, genus CON.ConclusionThe increased presence microbial-bacterial systemic circulation response appears positive all participants. An supplementation period prior consumption did not provide attenuation EHS-associated

Язык: Английский

Процитировано

3
Case Series: Management of Exercise-Associated Gastrointestinal Symptoms in Endurance Athletes Using a High-Carbohydrate Low-FODMAP Therapeutic Intervention DOI
Rachel Scrivin, Gary Slater, Ricardo J. S. Costa

и другие.

International Journal of Sport Nutrition and Exercise Metabolism, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Янв. 1, 2025

This case-series describes a four-phase management approach implementing gastrointestinal assessment during exercise (GastroAxEx) to develop therapeutic interventions for athletes affected by exercise-associated symptoms (Ex-GIS). Recreational elite-level who experienced recurrent severe Ex-GIS (n = 9) and controls 2) (without Ex-GIS) volunteered participate in the case series. The four-phased involved clinical (Phase 1), standardized laboratory GastroAxEx where physiological strain GIS data were collected 2), individualized intervention strategies based on Phase 2 outcomes that specifically included implementation of 48-hr high carbohydrate low FODMAP diet 3), monitoring adjustment 4). majority 6/9) consumed <400 ml/hr fluid ad libitum, resulting 2%-4% body mass loss, <40 g/hr exogenous 8/9), GastroAxEx. Severe (predominantly loose stools) was reported n 4/9 athletes, whereas 8/9 recovery period. All food intake tolerance recovery. Orocecal transit time slow or delayed 2/9 athletes. Most 8/9) successfully implemented prior improved targeted event. In addition, incidence severity reduced, perceived work output events. A before endurance appears be valuable addition suggested used mitigate Ex-GIS.

Язык: Английский

Процитировано

0
Impact of moderate environmental heat stress during running exercise on circulating markers of gastrointestinal integrity in endurance athletes DOI Creative Commons
Thomas Beiter, Gunnar Erz,

Anna Würden

и другие.

Physiological Reports, Год журнала: 2025, Номер 13(7)

Опубликована: Апрель 1, 2025

In the present study, we aimed to determine effect of moderate ambient heat stress on exercise-provoked patterns "leaky gut" biomarkers and markers in well-trained athletes. Eleven triathletes performed a strenuous 1-h treadmill run, both under normal conditions (N, 18-21°C) as well environmental (H, 28-30°C). Core body temperature (Tc), heart rate (HR), rating perceived exertion (RPE) significantly increased conditions, with higher values during after H run. We observed significant main acute exercise circulating leukocyte numbers, release cell-free human DNA (cfDNA) but not bacterial (bacDNA), plasma levels intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide-binding (LBP), endotoxin (LPS), D-lactate. Exercising accelerated mobilization neutrophils lymphocytes, affected cfDNA, D-lactate, I-FABP, creatinine, blood potassium levels. Multiple correlation analysis revealed association between Tc, max cfDNA (r = 0.583, p 0.012) I-FABP 0.554, 0.026). Our data indicate that exercising may only affect paracellular also transcellular permeability.

Язык: Английский

Процитировано

0