Clinical impact of aging on outcomes of cardioneuroablation for reflex syncope or functional bradycardia: Results from the cardionEuroabLation: patiEnt selection, imaGe integrAtioN and outComEs—The ELEGANCE multicenter study
Heart Rhythm,
Год журнала:
2023,
Номер
20(9), С. 1279 - 1286
Опубликована: Июнь 15, 2023
Язык: Английский
Cardioneuroablation for reflex syncope or functional bradyarrhytmias: new insight from a single center experience
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 13, 2025
Background
Cardioneuroablation
(CNA)
is
a
new
approach
to
treat
reflex
syncope
and
functional
bradyarrhytmias
caused
by
autonomic
imbalance.
We
report
our
experience
using
CNA.
Method
From
September
2022
July
2023,
we
took
care
of
21
patients
(mean
age
42
±
years;
62%
male)
affected
or
bradyarrhythmias.
All
underwent
CNA
under
conscious
sedation
targeting
the
superior
and/or
inferior
paraseptal
ganglionated
plexus
(GPs).
Results
Nine
were
vasovagal
(VVS)
twelve
In
3
cases
(14%)
ablation
was
performed
only
on
GPs
right
atrium,
while
in
remaining
86%
biatrial
lesions.
As
regards
acute
results,
highlighted
an
increase
sinus
heart
rate
(12
15
bpm,
p
=
0.001),
shortening
PQ
interval
(−18
18
msec,
<
reduction
correct
node
recovery
times
(cSNRT)
(−142
204
0.114),
AH
(−31
26
0.008),
effective
refractory
period
atrio-ventricular
(−156;
interquartile
range
from
−30
−160
0.042)
Wencheback
point
(27
20
0.001).
At
follow-up,
single
patient,
due
persistent
symptoms
bradyarrhythmic
disorder,
permanent
pacemaker
implantation;
no
other
patient
had
recurrence
syncope,
all
remained
persistently
asymptomatic.
Conclusion
Our
results
confirm
efficacy
safety
for
treatment
VVS
bradyarrhythmias,
although
further
studies
are
needed
support
these
findings.
Язык: Английский
Safety and efficacy of cardioneuroablation for vagal bradycardia in a single arm prospective study
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 11, 2024
Cardioneuroablation
(CNA)
is
currently
considered
as
a
promising
treatment
option
for
patients
with
symptomatic
bradycardia
caused
by
vagotonia.
This
study
aims
to
further
investigate
its
safety
and
efficacy
in
suffering
from
vagal
bradycardia.
A
total
of
60
who
underwent
CNA
the
First
Affiliated
Hospital
Xinjiang
Medical
University
November
2019
June
2022.
Preoperative
atropine
tests
revealed
abnormal
tone
elevation
all
patients.
First,
electroanatomic
structures
left
atrium
was
mapped
out
using
Carto
3
system,
according
protocol
purely
anatomy-guided
local
fractionated
intracardiac
electrogram-guided
methods.
The
upper
limit
ablation
power
superior
ganglion
(SLGP)
right
anterior
(RAGP)
not
more
than
45W
an
index
450.Postoperative
transesophageal
cardiac
electrophysiological
examination
performed
1
months
after
surgery.
test
conducted
when
appropriate.
Twelve-lead
electrocardiogram,
Holter
skin
sympathetic
nerve
activity
were
reviewed
at
1,
3,
6
12
operation.
Adverse
events
such
pacemaker
implantation
other
complications
also
recorded
analyze
vagus
Sixty
enrolled
(38
males,
mean
age
36.67
±
9.44,
ranging
18
50
years
old).
None
had
vascular
injury,
thromboembolism,
pericardial
effusion,
or
surgical
complications.
heart
rate,
minimum
low
frequency,
low/high
acceleration
capacity
increased
significantly
CNA.
Conversely,
SDNN,
PNN50,
rMSSD,
high
deceleration
rate
values
decreased
(all
P
<
0.05).
At
ablation,
average
maximum
remained
higher
those
before
lower
above
results
continued
follow
up
There
no
significant
difference
indicators
compared
>
remaining
81.67%
(49/60)
good
clinical
results,
episodes
arrhythmia
during
follow-up.
may
be
safe
effective
vagal-induced
bradycardia,
subject
confirmation
larger
multicenter
trials.
Язык: Английский
The role of P21-activated kinase (Pak1) in sinus node function
Journal of Molecular and Cellular Cardiology,
Год журнала:
2023,
Номер
179, С. 90 - 101
Опубликована: Апрель 20, 2023
Язык: Английский
Cardiac Geometry and Function in Patients with Reflex Syncope
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(22), С. 6852 - 6852
Опубликована: Ноя. 14, 2024
Reflex
syncope
(RS)
is
the
most
prevalent
form
of
syncope,
yet
its
pathophysiology
and
clinical
presentation
are
not
well
understood.
Despite
controversy,
‘ventricular
theory’
remains
plausible
hypothesis
to
explain
RS
in
susceptible
patients.
Certain
assumptions
regarding
geometry
function
heart
essential
supporting
this
theory.
Given
these
considerations,
goal
review
was
try
integrate
data
on
morphology
a
phenotype
patient
RS.
Previous
research
suggests
that
small
left
ventricle
atria,
addition
normo-
or
hypercontractile
myocardium,
predispose
more
syncopal
events.
These
findings
have
been
confirmed
different
subsets
patients,
including
those
with
chronic
fatigue
syndrome,
highlighting
common
pathophysiologic
pathways
subgroups
population.
Heart
seem
play
role
treatment
strategies
for
administration
medications,
pacing,
possibly
cardioneural
ablation.
In
addition,
parameters
related
chambers
electrical
activation
predictive
value
recurrence.
could
be
included
future
improve
accuracy
models
Язык: Английский