Journal of Natural Remedies,
Год журнала:
2024,
Номер
unknown, С. 2583 - 2597
Опубликована: Дек. 31, 2024
Introduction:
Phytosterols
play
a
major
role
in
the
management
of
cardiovascular
diseases.
Beta-sitosterol
sourced
from
various
plants
showed
better
therapeutic
activity
and
mechanism
treating
However,
there
has
been
no
comprehensive
review
distribution
beta-sitosterol
its
activities
cardiac
Methods:
Thus,
includes
occurrence
relevance
with
outcomes
on
The
literature
collection
process
was
conducted
using
scientific
databases
such
as
Pubmed,
science
direct,
Google
Scholar
books
for
concise
evaluation
study.
Results:
resultant
concised
to
biological
sources
isolation,
efficacy
against
diseases
by
decreasing
cholesterol
absorption
which
leads
decrease
Low-density
Lipoprotein
(LDL)
levels.
Conclusion:
Further
preclinical
clinical
studies
can
be
explored
explore
beta-sitosterol.
Food Frontiers,
Год журнала:
2024,
Номер
5(2), С. 820 - 832
Опубликована: Янв. 24, 2024
Abstract
This
study
focused
on
the
production
of
angiotensin‐converting
enzyme
inhibitory
peptides
(ACEIPs)
from
peanut
meal
(
Arachis
hypogaea
Linn)
fermented
by
Lactobacillus
pentosus
.
The
fermentation
process
was
optimized
using
response
surface
methodology
with
ACE
activity
as
experimental
indicator.
ACEIPs
were
further
purified
after
ultrafiltration
and
Sephadex
G‐25
gel
chromatography.
effect
different
molecular
weights
(ranging
0.5
to
1.5
kDa)
ACEIP
investigated,
a
maximum
rate
48.83%
achieved.
content
78.95%.
Amino
acid
analysis
revealed
that
hydrophobic
amino
acids
accounted
for
43.09%
total
content.
Among
identified
acids,
glutamic
had
highest
14.94%,
followed
leucine
aspartic
acid.
Matrix‐assisted
laser
desorption/ionization
time‐of‐flight–mass
spectrometry
(MS)
liquid
chromatography–tandem
MS
used
identify
selected
ACEIPs,
yielding
six
good
stability
high
hydrophilicity.
Flexible
docking
simulated
AutoDock
Vina
(v1.5.7).
result
showed
formed
11,
8,
7,
9,
6
hydrogen
bonds
residues,
lowest
binding
energies
between
them
−9.8,
−8.1,
−9.0,
−9.3,
−8.2,
and−9.1
kcal/mol,
respectively.
them,
GFGINAENNHRIF
exhibited
superior
stability.
Frontiers in Plant Science,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 12, 2023
Among
seed
attributes,
weight
is
one
of
the
main
factors
determining
soybean
harvest
index.
Recently,
focus
breeding
has
shifted
to
improving
size
and
for
crop
optimization
in
terms
oil
yield.
With
recent
technological
advancements,
there
an
increasing
application
imaging
sensors
that
provide
simple,
real-time,
non-destructive,
inexpensive
image
data
rapid
image-based
prediction
traits
plant
programs.
The
present
work
related
digital
analysis
hundred-seed
(HSW)
soybean.
architectural
(i-traits)
measured
were
area
(AS),
perimeter
length
(PL),
(L),
width
(W),
length-to-width
ratio
(LWR),
intersection
(IS),
circularity
(CS),
distance
between
IS
CG
(DS).
phenotypic
investigation
revealed
significant
genetic
variability
among
164
genotypes
both
i-traits
manually
weight.
Seven
popular
machine
learning
(ML)
algorithms,
namely
Simple
Linear
Regression
(SLR),
Multiple
(MLR),
Random
Forest
(RF),
Support
Vector
(SVR),
LASSO
(LR),
Ridge
(RR),
Elastic
Net
(EN),
used
create
models
can
predict
seeds
based
on
novel
features
derived
from
Red-Green-Blue
(RGB)/visual
image.
models,
random
forest
multiple
linear
regression
use
explanatory
variables
(AS,
L,
W,
DS)
identified
as
best
predicting
with
highest
accuracy
(coefficient
determination,
R2=0.98
0.94,
respectively)
lowest
error,
i.e.,
root
mean
square
error
(RMSE)
absolute
(MAE).
Finally,
principal
components
(PCA)
a
hierarchical
clustering
approach
identify
IC538070
superior
genotype
larger
donors/traits
potentially
be
improvement
Molecules,
Год журнала:
2023,
Номер
28(16), С. 6012 - 6012
Опубликована: Авг. 11, 2023
This
research
aimed
to
determine
the
biofunctional
properties
of
wheat
flour
(WF)
protein
fractions
and
modifications
antioxidant,
anti-α-amylase
anti-angiotensin-I
converting
enzyme
(ACE)
activities
induced
by
action
digestive
endopeptidases
in
vitro.
A
molecular
characterization
most
abundant
fractions,
i.e.,
albumins,
glutelins-1,
glutelins-2
prolamins,
showed
that
low-
high-MW
polypeptides
rich
cysteine,
glutamic
acid
leucine
were
present
albumins
glutelins,
whereas
low-MW
subunits
with
a
high
proportion
polar
amino
acids
prevailed
prolamins.
Prolamins
exhibited
second-highest
water
holding
capacity
(54%)
after
WF
(84%),
while
provided
superior
foam
stability
(76%).
Prolamins,
glutenins-1
globulins
demonstrated
highest
antioxidant
activity
(up
95%,
68%
59%,
respectively)
both
before
hydrolysis
pepsin
(P-H)
or
trypsin-chymotrypsin
(TC-H).
strongly
inhibited
α-amylase
(>90%)
TC-H,
P-H
(55-71%).
Moreover,
significantly
increased
inhibition
from
53
74%.
The
strong
ACE
inhibitory
(70-89%)
included
prolamins
TC-H
P-H,
as
well
P-H.
novel
evidence
indicates
their
peptide-enriched
P
TC
hydrolysates
are
excellent
sources
multifunctional
bioactives
antihyperglycemic
antihypertensive
potential.
The
hallmarks
of
type
2
diabetes
(T2D)
include
peripheral
insulin
resistance
and
insufficiency.Given
the
significance
T2D
as
a
major
public
health
concern,
goal
this
review
article
is
to
highlight
role
bioactive
properties
soybeans
in
prevention,
control,
management
disease.This
study
examined
how
molecules
from
modulate
key
enzymes
that
affect
T2D.A
systematic
search
electronic
databases
such
PubMed
Google
Scholar
was
conducted
find
relevant
original
studies
or
non-original
peer-reviewed
papers
published
on
subject.Keyword
combinations
"Soy
OR
soybeans",
"Soybeans
AND
anti-inflammatory",
anti-oxidative",
antidiabetic"
were
used
search.A
also
all
mentioned
review.A
total
194
articles
English
selected.Both
vivo
vitro
experiments,
human
clinical
trials
have
proven
marked
efficacy
these
suppressing
enzyme
biomarkers
pathogenesis.Based
empirical
research,
consumption
soybean
products
ingredients
associated
with
lower
incidence
T2D.These
findings
will
contribute
present
understanding
therapeutic
potential
soy-derived
compounds.However,
does
not
capture
individual
variances
biomolecules;
hence,
there
need
for
more
future
pharmacokinetic
better
understand
interactions,
safety,
concerns.
