Integrated proteomics reveals enrichment of oxidative stress and inflammatory proteins in the urine and stone matrix of calcium oxalate stone formers

Urolithiasis, Год журнала: 2025, Номер 53(1)

Опубликована: Фев. 6, 2025

Язык: Английский

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Association between oxidative balance score and rheumatoid arthritis in female: a cross-sectional study

BMC Women s Health, Год журнала: 2024, Номер 24(1)

Опубликована: Апрель 6, 2024

Abstract Objective Although oxidative stress is a recognized factor of inflammation, the correlation between balance score (OBS), biomarker indicating oxidation and antioxidant, rheumatoid arthritis (RA), an immune system disease that tends to occur in women, remains unexplored. Hence, aim this study was investigate potential association OBS RA women. Methods Observational surveys were performed by employing information extracted from National Health Nutrition Examination Survey (NHANES) for period 2007–2018. Various statistical techniques employed RA, encompassing multivariable logistic regression analysis, subgroup analyses, smooth curve fitting, threshold effect analysis. Results The included 8219 female participants, including 597 patients with RA. results showed higher Total (TOBS) significantly correlated lower prevalence entirely modified model [odd ratio (OR) = 0.968; 95% confidence interval (CI) 0.952 0.984; P 0.0001]. Dietary (DOBS) lifestyle (LOBS) also negatively This remarkably consistent across TOBS subgroups age, race, education level, family poverty-to-income (PIR), hypertension diabetes. Smooth fitting analysis revealed linear relationship Conclusions Overall, associated female. suggested antioxidant diet may be promising measures prevent

Язык: Английский

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Relationship between oxidative balance indicators and Chronic Kidney Disease

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0315344 - e0315344

Опубликована: Янв. 3, 2025

Introduction Chronic Kidney Disease (CKD) is a growing global health issue, affecting approximately 9.1% of the world’s population. Oxidative stress believed to play key role in CKD development, with indicators such as Balance Score (OBS), Pro-Oxidant-Antioxidant (PAB), and Total Antioxidant Capacity (TAC) being particular interest. However, their association remains unclear. Methods This study conducted cross-sectional analysis using data from National Health Nutrition Examination Survey (NHANES) 2009–2018. A total 18,951 participants were included after applying specific inclusion criteria. Logistic regression models restricted cubic spline employed examine associations between these oxidative balance CKD. Subgroup interaction analyses also for further analyses. Finally, ROC curve was used assess predictive performance risk. Results After adjusting various confounding factors, higher levels OBS PAB significantly associated reduced risk (OR = 0.97, 95% CI: 0.96–0.99, P < 0.001; OR 0.94, 0.92–0.97, 0.001, respectively). The ORs highest quartiles 0.60 (95% 0.49–0.75, 0.001) 0.77 0.63–0.94, 0.013), respectively. In contrast, TAC showed no significant indicated that had superior ability (AUC 0.579) compared 0.519) 0.492). Conclusion suggests indicators, particularly PAB, are inversely risk, while link. demonstrated strongest among indicators. These findings highlight potential prevention. Further research needed confirm diverse populations explore underlying mechanisms.

Язык: Английский

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Oxidative Balance, Nutrition, and Cognitive Function in Older Adults: A Mediation Analysis Using NHANES 2011–2014 Data

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

Background The global rise in cognitive function impairment (CFI) parallels an aging population. While oxidative stress is considered a contributing factor, its role CFI remains underexplored. This study examines the relationship between balance score (OBS) and using 2011–2014 National Health Nutrition Examination Survey (NHANES) data. Methods Data from 2,089 participants aged 60 above were analyzed. OBS was calculated 16 dietary 4 lifestyle components. Cognitive evaluated Consortium to Establish Registry for Alzheimer’s Disease (CERAD), Animal Fluency Test (AFT), Digit Symbol Substitution (DSST). Multivariable weighted logistic regression, restricted cubic splines (RCS), subgroup, mediation analyses assessed association CFI, adjusting age, sex, comorbidities. Sensitivity analysis tested result robustness. Results Higher significantly associated with lower risk after confounders. RCS indicated linear negative correlation CFI. Subgroup showed stronger associations non-Hispanic Black White populations. Mediation revealed Geriatric Nutritional Risk Index (GNRI) albumin/globulin ratio (AGR) had opposing mediating effects. confirmed stability of these findings unweighted models. Conclusion linked reduced older adults. Enhancing through diet modifications could be promising strategy maintain health.

Язык: Английский

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Assessment of oxidative balance score with hypertension and arterial stiffness in children and adolescents: NHANES 2001–2018

European Journal of Nutrition, Год журнала: 2025, Номер 64(4)

Опубликована: Май 12, 2025

To investigate the complex relationship between oxidative balance score (OBS), hypertension (HTN) and arterial stiffness in children adolescents utilizing data gathered from National Health Nutrition Examination Survey (NHANES). Through NHANES (2001-2018), OBS, comprising dietary lifestyle components, was calculated categorized into tertiles. The correlation OBS HTN explored employing weighted multivariate logistic regression. Stratified analyses were further performed to evaluate associations across different subgroups. A total of 11,754 ultimately enrolled analyses. High tertiles demonstrated a consistent negative association with models. Compared lowest tertile, risk highest tertile decreased by 37% (95% CI 0.44-0.90, p = 0.011). After dividing Lifestyle exhibited significant inverse HTN, while showed no correlation. notably revealed protective impacts on males. Restricted cubic spline analysis confirmed nonlinear HTN. Moreover, elevated significantly associated ePWV, indicating potential link OBS. In summary, inversely correlated high Adopting wholesome enriched antioxidants boost may help shield risk.

Язык: Английский

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Cymbopogon proximus and Petroselinum crispum seed ethanolic extract/Gum Arabic nanogel emulsion: Preventing ethylene glycol and ammonium chloride-induced urolithiasis in rats

Urolithiasis, Год журнала: 2024, Номер 52(1)

Опубликована: Апрель 2, 2024

Abstract Urolithiasis is a prevalent urological disorder that contributes significantly to global morbidity. This study aimed assess the anti-urolithic effects of Cymbopogon proximus (Halfa Bar) and Petroselinum crispum (parsley) seed ethanolic extract /Gum Arabic (GA) emulsion, its nanogel form against ethylene glycol (EG) ammonium chloride (AC)-induced experimental urolithiasis in rats. Rats were divided into four groups: group 1 served as normal control, 2 received EG with AC drinking water for 14 days induce urolithiasis, groups 3 4 orally administered emulsion (600 mg/kg/day) 7 days, followed by co-administration days. Urolithiatic rats exhibited significant decrease urinary excreted magnesium, non-enzymic antioxidant glutathione catalase activity. Moreover, they showed an increase oxalate crystal numbers various promoters, including calcium, oxalate, phosphate, uric acid. Renal function parameters lipid peroxidation intensified. Treatment either or elevated inhibitors, levels, activities. Reduced numbers, promoters’ excretion, renal parameters, while improving histopathological changes. it decreased deposition score expression Tumer necrosis factor-α (TNF-α) cleaved caspase-3. Notably, superior compared emulsion. (C. ) (P. extracts/GA demonstrated protective induced stones mitigating kidney dysfunction, formation, histological alterations.

Язык: Английский

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Association of the oxidative balance score with sarcopenia among young and middle-aged adults: findings from NHANES 2011–2018

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 4, 2024

Background Sarcopenia is associated with oxidative stress. The Oxidative Balance Score (OBS) commonly used to assess dietary and lifestyle exposure However, few studies in the literature have assessed correlation between sarcopenia OBS. Aim This study aimed association OBS among young middle-aged adults United States using data from National Health Nutrition Examination Survey (NHANES). Method Weighted logistic regression analysis was investigate based on NHANES 2011–2018. Subgroup analyses were performed observe consistency of outcomes, stability results tested sensitivity analyses. Result final sample included 5,525 American adults. A higher a lower risk sarcopenia. In fully adjusted model, second (odds ratio [OR]: 0.62, 95% confidence interval [CI]: 0.41, 0.94; p = 0.023), third (OR: 0.50; CI: 0.34, 0.74; &lt; 0.001), highest quartiles 0.18; 0.11, 0.28; 0.001) risks when compared lowest quartile. consistent across both scores. Our subgroup revealed no significant differences subgroups variables interaction analysis. Sensitivity similar results. Conclusion showed that antioxidant may decrease developing Higher scores indicate greater protection against sarcopenia; however, further clinical are warranted confirm these findings.

Язык: Английский

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Association of oxidative balance score with hearing loss and tinnitus: NHANES 1999–2018

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 19, 2024

Background Oxidative stress is associated with the occurrence of hearing loss and tinnitus. The oxidative balance score (OBS), a composite indicator evaluating between antioxidant pro-oxidative components across various dietary lifestyle factors, indicates overall status. However, association OBS tinnitus has not been reported previously. Methods Cross-sectional data from National Health Nutrition Examination Survey (NHANES) 1999–2018 were analyzed. Weighted multivariable logistic regression, weighted linear restricted cubic spline curve (RCS) regression employed to explore relationship at speech, low, high frequencies, along Subgroup analysis sensitivity used ascertain consistency subgroups stability results. Results We included 13,715 21,644 individuals investigate loss, as well tinnitus, respectively. second, third, fourth quartiles significantly lower risk compared lowest quartile. RCS indicated negative Most associations maintained in subgroup analysis. Additionally, independently contribute protection against Conclusion negatively correlated findings suggest that combined diet hold promise potential strategies for reducing prevalence

Язык: Английский

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The Role of the Gut Microbiome in Kidney Stone Disease

Urologic Clinics of North America, Год журнала: 2024, Номер 51(4), С. 475 - 482

Опубликована: Авг. 17, 2024

Язык: Английский

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Association of the oxidative balance score and chronic kidney disease: insights from the national health and nutrition examination survey 2009–2018

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Сен. 27, 2024

Introduction Oxidative stress plays a pivotal role in the pathogenesis of chronic kidney disease (CKD). The oxidative balance score (OBS) was devised to quantify overall state, integrating pro-oxidant and antioxidant influences from both dietary intake lifestyle practices. aim this study delve into relationship between OBS CKD within adult population United States. Methods Utilizing data National Health Nutrition Examination Survey (NHANES) spanning 2009–2018, we derived 16 four factors. We employed weighted multivariate regression probe link CKD. Additionally, undertook subgroup analyses applied Restricted Cubic Spline Regression (RCS) for further analyses. Results This encompassed 19,444 participants. Logistic analysis consistently demonstrated protective effect higher on In Model 3, each unit increase associated with 2% reduction risk (95% CI: 0.97–0.99, p &lt; 0.001) 4% reduced estimated glomerular filtration rate (eGFR) 0.95–0.98, 0.001). highest quintile (Q4) also showed significant reductions (OR: 0.66, 95% 0.53–0.82, eGFR 0.51, 0.37–0.69, 3. RCS revealed linear Subgroup indicated associations most subgroups, except those without hypertension or cardiovascular disease. interaction that age, hypertension, diabetes significantly modify association risk. Conclusion An elevated OBS, reflecting predominance antioxidants, correlates diminished American demographic. These insights emphasize potential influence equilibrium development

Язык: Английский

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