Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 14, 2025
Introduction
Infertility
is
characterized
by
the
failure
to
conceive
after
12
months
of
unprotected
sexual
intercourse.
In
assisted
reproduction
technologies
(ARTs),
in-vitro
fertilization
and
embryo
transfer
(IVF-ET)
are
pivotal,
with
quality
essential
for
successful
implantation.
Objective
This
systematic
review
meta-analysis
aimed
explore
prevalence
embryonic
factors
involved
in
implantation
process,
concentrating
on
following
research
inquiries:
1)
rates
euploid
versus
untested
transfers;
2)
efficiency
transferring
good
embryos
different
age
groups;
3)
impact
transfers
gestational
carriers;
4)
donated
gametes/embryos.
The
goal
identify
critical
points
improve
therapies.
Methods
A
comprehensive
literature
search
identified
1474
relevant
papers,
11
which
met
inclusion
criteria.
information
was
gathered
using
a
standardized
form,
risk
bias
evaluated.
subgroups
determine
conducted
synthesize
results.
Furthermore,
data
extracted
from
registries
document
persistent
secondary
role
extraembryonic
determinants
Results
demonstrated
that
preimplantation
genetic
testing
aneuploidy
(PGT-A)
significantly
increased
odds
Age
found
influence
factors,
older
women
experiencing
reduced
as
carriers.
However,
overall
incidence
low.
highlights
need
focus
PGT-A,
diagnostic
hysteroscopy,
endometrial
receptivity
improving
rates.
Conclusion
Implantation
success
ARTs
largely
depends
euploidy.
While
achieving
three
greatly
increases
rates,
it
challenging
women.
Extraembryonic
although
present,
have
marginal
impact.
Subsequent
studies
ought
concentrate
modulating
responses
immunologically
developing
algorithms
precision
predicting
success;
well
timing
occurrence
dormant
phenomena
also
warrants
further
investigation.
Язык: Английский
Correlation Between Hormonal Modulation and Pregnancy Outcomes: The Impact of Estrogen Priming and Endometrial Receptivity in Intrauterine Insemination
Cureus,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 4, 2025
Язык: Английский
Maternal age at transfer following autologous oocyte cryopreservation is not associated with live birth rates
Journal of Assisted Reproduction and Genetics,
Год журнала:
2024,
Номер
41(8), С. 1977 - 1984
Опубликована: Июнь 13, 2024
Язык: Английский
Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 3, 2024
The
endometrium
plays
a
fundamental
role
in
the
reproductive
system
yet
many
etiologies
of
infertility-related
endometrial
diseases
such
as
endometriosis,
adenomyosis,
Asherman's
syndrome
or
cancer
remain
unknown.
There
are
currently
no
treatments
that
minimize
effects
this
devastating
disorder.
Appropriate
model
systems
closely
mimic
architecture
and
function
healthy
pathological
states
needed
to
understand
underlying
molecular
pathways
develop
novel
more
effective
treatments.
This
review
summarizes
key
milestones
Язык: Английский