Biomedicines,
Год журнала:
2024,
Номер
12(12), С. 2811 - 2811
Опубликована: Дек. 11, 2024
Mesenchymal
stem/stromal
cells
(MSCs)
are
involved
in
the
maintenance
and
regeneration
of
a
large
variety
tissues
due
to
their
stemness
multi-lineage
differentiation
capability.
Harnessing
these
advantageous
features,
flurry
clinical
trials
have
focused
on
MSCs
treat
different
pathologies,
but
only
few
protocols
received
regulatory
approval
so
far.
Among
various
causes
hindering
MSCs'
efficacy
is
emergence
cellular
senescence,
which
has
been
correlated
with
specific
characteristics,
such
as
morphological
epigenetic
alterations,
DNA
damage,
ROS
production,
mitochondrial
dysfunction,
telomere
shortening,
non-coding
RNAs,
loss
proteostasis,
peculiar
senescence-associated
secretory
phenotype.
Several
strategies
investigated
for
delaying
or
even
hopefully
reverting
onset
assessed
by
senescent
phenotype
MSCs.
Here,
authors
reviewed
most
updated
literature
potential
particular
emphasis
current
future
therapeutic
approaches
aimed
at
senescence
and/or
extending
functional
lifespan
stem
cells.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(10), С. 1354 - 1354
Опубликована: Окт. 10, 2024
Metabolic-Associated
Fatty
Liver
Disease
(MAFLD)
is
a
clinical-pathological
scenario
that
occurs
due
to
the
accumulation
of
triglycerides
in
hepatocytes
which
considered
significant
cause
liver
conditions
and
contributes
an
increased
risk
death
worldwide.
Even
though
possible
causes
MAFLD
can
involve
interaction
genetics,
hormones,
nutrition,
lifestyle
(diet
sedentary
lifestyle)
most
influential
factor
developing
this
condition.
Polyphenols
comprise
many
natural
chemical
compounds
be
helpful
managing
metabolic
diseases.
Therefore,
aim
review
was
investigate
impact
oxidative
stress,
inflammation,
mitochondrial
dysfunction,
role
polyphenols
MAFLD.
Some
reverse
part
damage
related
or
among
them
are
anthocyanin,
baicalin,
catechin,
curcumin,
chlorogenic
acid,
didymin,
epigallocatechin-3-gallate,
luteolin,
mangiferin,
puerarin,
punicalagin,
resveratrol,
silymarin.
These
have
actions
reducing
plasma
enzymes,
body
mass
index,
waist
circumference,
adipose
visceral
indices,
lipids,
glycated
hemoglobin,
insulin
resistance,
HOMA
index.
They
also
reduce
nuclear
factor-KB
(NF-KB),
interleukin
(IL)-1β,
IL-6,
tumor
necrosis
factor-α
(TNF-α),
blood
pressure,
fat
content,
steatosis
fibrosis.
On
other
hand,
they
improve
HDL-c,
adiponectin
levels,
fibrogenesis
markers.
results
show
promising
prevention
treatment
Journal of Integrated Science and Technology,
Год журнала:
2025,
Номер
13(3)
Опубликована: Янв. 7, 2025
The
environmental
pollution
poses
a
serious
global
health
risk,
contributing
to
high
morbidity
and
mortality
rates.
Neurological
disorders,
such
as
Alzheimer's,
Parkinson's,
Schizophrenia,
ALS,
Huntington's
disease,
are
increasingly
prevalent
characterized
by
both
structural
functional
abnormalities
in
neurons
of
the
brain
spinal
cord.
Understanding
neuro-impact
toxins
is
crucial
for
developing
effective
prevention
intervention
strategies.
This
review
article
investigates
complex
interactions
between
neurological
health,
focusing
on
their
role
development
progression
neurodegenerative
neuropsychiatric
disorders.
Key
mechanisms
include
oxidative
stress,
mitochondrial
dysfunction,
and,
disruption
neurotransmitter
systems.
It
highlights
pathways
through
which
these
exert
effects,
presents
epidemiological
evidence
linking
toxin
exposure
discusses
potential
public
implications.
By
elucidating
connections,
paper
aims
enhance
understanding
determinants
health.
Background
Few
studies
have
focused
on
the
correlation
between
leukocyte
telomere
length
(LTL)
and
cancer-related
mortality
or
identified
potential
factors
that
mediate
relationship
LTL
among
chronic
kidney
disease
(CKD)
patients.
Our
study
aimed
to
explore
associations
all-cause
cause-specific
identify
underlying
mediators.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Март 27, 2025
Background
Magnesium
deficiency
and
low
levels
of
the
anti-aging
protein
Klotho
have
been
independently
associated
with
various
age-related
diseases.
The
Depletion
Score
(MDS)
is
recognized
as
a
more
valuable
reliable
predictor
body
magnesium
status
than
traditional
clinical
markers
such
serum
urine
magnesium.
However,
relationship
between
remains
unexplored.
This
study
aimed
to
investigate
association
depletion,
quantified
by
MDS,
in
US
adults.
Methods
We
analyzed
data
from
11,387
participants
aged
40–79
years
National
Health
Nutrition
Examination
Survey
(NHANES)
2007–2016.
Participants
were
divided
into
three
groups
based
on
MDS:
(0–1
points),
middle
(2
high
(3–5
reflecting
cumulative
risks
depletion
derived
diuretic
use,
proton
pump
inhibitors,
renal
function,
alcohol
intake.
Serum
measured
using
validated
ELISA
assay.
Sample-weighted
multivariable
linear
regression
models
used
examine
MDS
levels,
adjusting
for
age,
sex,
race,
socioeconomic
status,
lifestyle
factors
(smoking,
use),
parameters
(body
mass
index,
blood
pressure,
lipid
levels),
energy
Results
weighted
average
concentrations
decreased
significantly
across
(low:
864.50,
middle:
805.67,
high:
755.02
pg./mL;
p
<
0.0001).
After
full
adjustment,
compared
group,
had
lower
(
β
=
−35.49,
95%
CI:
−62.29
−8.69;
−64.82,
−115.30
−14.34,
respectively;
trend
0.003).
inverse
remained
consistent
subgroups,
particularly
strong
relationships
observed
individuals
BMI
<25,
current
smokers,
those
income.
Conclusion
provides
novel
evidence
an
new
indicator
large,
representative
sample
These
findings
suggest
that
monitoring
via
could
help
identify
at
risk
accelerated
aging,
prompting
interventions
dietary
adjustments
or
supplementation
high-risk
populations.
Further
research
warranted
elucidate
mechanisms
underlying
this
its
implications
Antioxidants,
Год журнала:
2025,
Номер
14(4), С. 421 - 421
Опубликована: Март 31, 2025
Aging
is
a
multifactorial
process
influenced
by
genetic
predisposition
and
lifestyle
choices.
Environmental
exposures
are
too
often
overlooked.
pollutants—ranging
from
airborne
particulate
matter
heavy
metals
to
endocrine
disruptors
microplastics—accelerate
biological
aging.
Oxidative
stress
major
molecular
initiating
event,
driving
inflammation
toxicity
across
levels.
We
detail
the
mechanisms
which
pollutants
enhance
reactive
oxygen
species
(ROS)
production.
This
oxidative
inflicts
damage
on
DNA,
proteins,
lipids,
accelerating
telomere
shortening,
dysregulating
autophagy,
ultimately
epigenetic
age
acceleration.
For
instance,
exposure
polycyclic
aromatic
hydrocarbons,
benzene,
pesticides
has
been
associated
with
increased
DNA
methylation
age.
Early-life
factors
such
as
tobacco
alcohol
consumption
further
contribute
accelerated
The
cumulative
loss
of
healthy
life
years
caused
these
can
conceivably
reach
between
5
10
per
person.
Addressing
pollutant-induced
aging
through
regulatory
measures,
changes,
therapeutic
interventions
essential
mitigate
their
detrimental
impacts,
extending
healthspan
improving
quality
in
populations.
