Molecular Mechanism of Microgravity-Induced Intestinal Flora Dysbiosis on the Abnormalities of Liver and Brain Metabolism DOI Open Access
Yi Bo Xiong, Jianguo Guo,

Wenchen Yu

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3094 - 3094

Опубликована: Март 27, 2025

Space flight has many adverse effects on the physiological functions of astronauts. Certain similarities have been observed in some processes rodents and astronauts space, although there are also differences. These make helpful models for initial investigations into space-induced changes. This study uses a 3D-Clinostat to simulate microgravity explores role space flight-induced liver brain abnormalities by comparing changes gut microbiota, serum metabolites, function biochemistry tissues between simulated (SMG) group mice wild type (WT) mice. The study, based hematoxylin-eosin (HE) staining, 16S sequencing technology, non-targeted metabolomics analysis, shows that tissue morphology SMG is abnormal, structure microbiota metabolite profile imbalanced. Furthermore, using PICRUST 2 we predicted results indicate metabolism (including lipid metabolism, amino acid sugar etc.) disrupted, neurotransmitters hormone secretion, suggesting close relationship metabolic dysfunction dysfunction. Additionally, high similarity fecal transplant (FMT) mice, biochemical differences compared WT suggest induces imbalances which turn triggers function. Finally, through MetaMapp analysis Pearson correlation found valeric acid, more likely be key relates microgravity-induced abnormalities, disorders further induced or functional brain. significant practical application value deepening understanding adaptability living organisms environment.

Язык: Английский

The crucial function of gut microbiota on gut-liver repair DOI Creative Commons
Yamei Wang,

Yan He,

Qianqian Zheng

и другие.

hLife, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Intestinal Microbiota Dysbiosis Role and Bacterial Translocation as a Factor for Septic Risk DOI Open Access
Ioannis Alexandros Charitos, Salvatore Scacco, Antonella Cotoia

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2028 - 2028

Опубликована: Фев. 26, 2025

The human immune system is closely linked to microbiota such as a complex symbiotic relationship during the coevolution of vertebrates and microorganisms. transfer microorganisms from mother's newborn begins before birth gestation considered initial phase intestinal (IM). gut an important site where can establish colonies. IM contains polymicrobial communities, which show interactions with diet host immunity. tendency towards dysbiosis influenced by local but also extra-intestinal factors inflammatory processes, infections, or septic state that aggravate it. Pathogens could trigger response, proinflammatory responses. In addition, changes in influence community structure additional translocation pathogenic non-pathogenic bacteria. Finally, inflammation has been found be factor growth microorganisms, particularly its role sepsis. aim this article able detect current knowledge mechanisms lead cause bacterial risk infection vice versa.

Язык: Английский

Процитировано

0
Molecular Mechanism of Microgravity-Induced Intestinal Flora Dysbiosis on the Abnormalities of Liver and Brain Metabolism DOI Open Access
Yi Bo Xiong, Jianguo Guo,

Wenchen Yu

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3094 - 3094

Опубликована: Март 27, 2025

Space flight has many adverse effects on the physiological functions of astronauts. Certain similarities have been observed in some processes rodents and astronauts space, although there are also differences. These make helpful models for initial investigations into space-induced changes. This study uses a 3D-Clinostat to simulate microgravity explores role space flight-induced liver brain abnormalities by comparing changes gut microbiota, serum metabolites, function biochemistry tissues between simulated (SMG) group mice wild type (WT) mice. The study, based hematoxylin-eosin (HE) staining, 16S sequencing technology, non-targeted metabolomics analysis, shows that tissue morphology SMG is abnormal, structure microbiota metabolite profile imbalanced. Furthermore, using PICRUST 2 we predicted results indicate metabolism (including lipid metabolism, amino acid sugar etc.) disrupted, neurotransmitters hormone secretion, suggesting close relationship metabolic dysfunction dysfunction. Additionally, high similarity fecal transplant (FMT) mice, biochemical differences compared WT suggest induces imbalances which turn triggers function. Finally, through MetaMapp analysis Pearson correlation found valeric acid, more likely be key relates microgravity-induced abnormalities, disorders further induced or functional brain. significant practical application value deepening understanding adaptability living organisms environment.

Язык: Английский

Процитировано

0