Protective Role of Physical Activity and Antioxidant Systems During Spermatogenesis DOI Creative Commons
Cristina Antinozzi, Luigi Di Luigi,

Laura Sireno

и другие.

Biomolecules, Год журнала: 2025, Номер 15(4), С. 478 - 478

Опубликована: Март 25, 2025

Oxidative stress is a significant factor that contributes to male infertility and sperm dysfunction. In this condition, an increase in ROS production exceeds the body’s antioxidant defenses, resulting decline spermatozoa quality fertilizing capacity. Furthermore, excessive has been linked promotion of genomic damage, lipid peroxidation, inflammation, altered enzyme activity, ultimately, irreversible alterations, cell death, seminal parameters associated with infertility. It established physical activity (PA), acting on inflammatory improving defense, can alleviate negative effects caused by free radicals, offering numerous health benefits positively influencing quality. The objective review highlight mechanisms production, physiological pathophysiological roles relation reproductive system, recent knowledge impact some protocols PA these systems molecular involved.

Язык: Английский

The microRNA-mediated apoptotic signaling axis in male reproduction: a possible and targetable culprit in male infertility DOI Creative Commons

Pengxia Yu,

Xue Zhao, Dan Zhou

и другие.

Cell Biology and Toxicology, Год журнала: 2025, Номер 41(1)

Опубликована: Март 5, 2025

Recently, infertility has emerged as a significant and prevalent public health concern warranting considerable attention. Apoptosis, recognized programmed cell death, constitutes crucial process essential for the maintenance of normal spermatogenesis. Multiple investigations have illustrated that dysregulated apoptosis reproductive cells, encompassing spermatogonial stem Sertoli Leydig serves causative factor in male infertility. MicroRNAs represent class small RNA molecules exert negative regulatory control over gene expression using direct interaction with messenger transcripts. Previous studies established aberrant miRNAs induces tissues, correlating dysfunctions In this review, we offer comprehensive overview their respective target genes implicated apoptotic process. As well, are involved multiple signaling pathways, namely PI3K/AKT, NOTCH, Wnt/β-catenin, mTOR cascades, exerting both positive effects. We additionally elucidate functions played by lncRNAs circular RNAs competing endogenous within cells. further illustrate external factors, including silica nanoparticles, Cyclosporine A, smoking, induce dysregulation miRNAs, resulting cells subsequent toxicity. Further, discuss implication heat stress, hypoxia, diabetes induced miRNA Finally, demonstrate modulation via traditional novel medicine could protect from be implemented therapeutic approach

Язык: Английский

Процитировано

0
Protective Role of Physical Activity and Antioxidant Systems During Spermatogenesis DOI Creative Commons
Cristina Antinozzi, Luigi Di Luigi,

Laura Sireno

и другие.

Biomolecules, Год журнала: 2025, Номер 15(4), С. 478 - 478

Опубликована: Март 25, 2025

Oxidative stress is a significant factor that contributes to male infertility and sperm dysfunction. In this condition, an increase in ROS production exceeds the body’s antioxidant defenses, resulting decline spermatozoa quality fertilizing capacity. Furthermore, excessive has been linked promotion of genomic damage, lipid peroxidation, inflammation, altered enzyme activity, ultimately, irreversible alterations, cell death, seminal parameters associated with infertility. It established physical activity (PA), acting on inflammatory improving defense, can alleviate negative effects caused by free radicals, offering numerous health benefits positively influencing quality. The objective review highlight mechanisms production, physiological pathophysiological roles relation reproductive system, recent knowledge impact some protocols PA these systems molecular involved.

Язык: Английский

Процитировано

0