Assessing the causal relationship between obesity and ankylosing spondylitis: A two-sample Mendelian randomization study DOI Creative Commons

Guanghua Deng,

Shu Yunjun

Medicine, Год журнала: 2025, Номер 104(21), С. e42559 - e42559

Опубликована: Май 23, 2025

This study aims to explore the potential causal relationship between obesity and ankylosing spondylitis (AS) using Mendelian randomization (MR) approach. Data were derived from a comprehensive genome-wide association dataset. Genetic loci that demonstrated significant, independent associations with both AS in populations of European ancestry selected as instrumental variables. Multiple MR analyses, including MR-Egger, weighted median, inverse variance weighting, employed assess impact on risk. To ensure reliability, heterogeneity, multiplicity tests conducted, robustness findings was evaluated through sensitivity analyses “leave-one-out” method. The weighting analysis revealed an odds ratio (OR) 0.95 95% confidence interval 0.76 1.19 P value .653. These results indicated no significant link development. Additionally, heterogeneity showed findings, while reinforced consistency conclusions. research did not find evidence development based two-sample genetic data evaluation. However, current study’s limitations, sample size design, highlight need for future larger cohorts further intricate AS.

Язык: Английский

The Impact of Exercise Training in a Hypobaric/Normobaric Hypoxic Environment on Cardiometabolic Health in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis DOI Creative Commons
Peng Liu,

Hao Chen,

Yue Deng

и другие.

Life, Год журнала: 2025, Номер 15(4), С. 566 - 566

Опубликована: Март 31, 2025

This systematic review and meta-analysis aims to comprehensively evaluate the effects of hypoxic training (HT) versus normoxic (NT) on cardiometabolic health parameters in overweight or obese adults. Searches were performed PubMed, Web Science, Embase, Scopus, Cochrane Library. A was using Stata 18 RevMan 5.4 software. Seventeen randomized controlled studies involving 517 participants included. HT significantly improved cardiorespiratory fitness (CRF) reduced systolic blood pressure (SBP) diastolic (DBP). Compared with NT, demonstrated a significant difference CRF, but no differences observed SBP DBP. The subgroup analysis CRF revealed that outperformed NT six aspects: aged < 45 years (Hedges’ g = 0.50), an intervention duration 8 weeks 0.43), three sessions per week 0.40), each session lasting min 0.23), FiO2 levels > 15% 0.69), high-load-intensity exercise 0.57). favorable improving among this advantage primarily reflected while impacts DBP similar.

Язык: Английский

Процитировано

0
Assessing the causal relationship between obesity and ankylosing spondylitis: A two-sample Mendelian randomization study DOI Creative Commons

Guanghua Deng,

Shu Yunjun

Medicine, Год журнала: 2025, Номер 104(21), С. e42559 - e42559

Опубликована: Май 23, 2025

This study aims to explore the potential causal relationship between obesity and ankylosing spondylitis (AS) using Mendelian randomization (MR) approach. Data were derived from a comprehensive genome-wide association dataset. Genetic loci that demonstrated significant, independent associations with both AS in populations of European ancestry selected as instrumental variables. Multiple MR analyses, including MR-Egger, weighted median, inverse variance weighting, employed assess impact on risk. To ensure reliability, heterogeneity, multiplicity tests conducted, robustness findings was evaluated through sensitivity analyses “leave-one-out” method. The weighting analysis revealed an odds ratio (OR) 0.95 95% confidence interval 0.76 1.19 P value .653. These results indicated no significant link development. Additionally, heterogeneity showed findings, while reinforced consistency conclusions. research did not find evidence development based two-sample genetic data evaluation. However, current study’s limitations, sample size design, highlight need for future larger cohorts further intricate AS.

Язык: Английский

Процитировано

0