A Transplantation Study in the High-Altitude Ecosystem of Ladakh suggests Site-specific Microenvironment is Key for Physiological Adaptation than Altitude.

Plant Physiology and Biochemistry, Год журнала: 2025, Номер unknown, С. 109532 - 109532

Опубликована: Янв. 1, 2025

Язык: Английский

Phenolic Acid Investigation and In Vitro Antioxidant and Antiacetylcholinesterase Potentials of Galeopsis spp. (Lamiaceae) from Romanian Flora

Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 599 - 599

Опубликована: Апрель 20, 2025

Background/Objectives Galeopsis spp. (Lamiaceae) are widely distributed across extensive areas in Romania, being used mainly for their sedative, neuroprotective, antioxidant, anti-inflammatory, expectorant, astringent, and diuretic properties. The paper reports the first time investigation of total phenolic content (TPC), flavonoid (TFC), acid profile roots, aerial parts, leaves from three wild-grown (G. bifida Boenn., G. speciosa Mill., tetrahit L.), along with antioxidant acetylcholinesterase (AChE) inhibitory potentials. Methods: ultra-high-performance liquid chromatography/ultraviolet/mass spectrometry (HPLC/UV/MS) method was identification quantification key acids. spectrophotometric applied determination TPC, TFC, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activities also ferric-reducing power (FRAP). High-performance thin-layer chromatography (HPTLC) employed assessment situ (DPPH assay) AChE Results: exhibit significant polyphenol accumulation. Chlorogenic most abundant compound, highest levels detected (22,347.907 ± 1117.395 μg/g), followed by parts (11,678.509 583.925 μg/g) (8712.628 435.631 μg/g). had DDPH activity, a half-maximal concentration (IC50) 0.458 0.03 mg/mL, demonstrating markedly stronger effect. Leaves consistently showed strongest DPPH activity all species, displaying low IC50 value 0.789 comparable to tetrahit. Aerial exhibited an intermediate effect, showing 8.102 0.49 while demonstrated at 1.511 0.11 mg/mL. inhibition increased progressively roots leaves, exhibiting effects inhibition, 4.002 0.32 (6.92 0.14 mg/mL) (6.97 0.68 mg/mL). Conclusions: Our study provides comprehensive analysis content, vitro neuroprotective potential bifida, speciosa, tetrahit) southwestern Romanian flora.

Язык: Английский

Research Progress of Genomics Applications in Secondary Metabolites of Medicinal Plants: A Case Study in Safflower

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3867 - 3867

Опубликована: Апрель 19, 2025

Medicinal plants, recognized as significant natural resources, have gained prominence in response to the increasing global demand for herbal medicines, necessitating large-scale production of these plants and their derivatives. are exposed a variety internal external factors that interact influence biosynthesis accumulation secondary metabolites. With rapid development omics technologies such genomics, transcriptomics, proteomics, metabolomics, multi-omics become important tools revealing complexity functionality organisms. They conducive further uncovering biological activities metabolites medicinal clarifying molecular mechanisms underlying Also, artificial intelligence (AI) technology accelerates comprehensive utilization high-dimensional datasets offers transformative potential analysis. However, there is currently no systematic review summarizing genomic metabolite plants. Safflower (Carthamus tinctorius L.) has rich diverse bioactive flavonoids, among which Hydroxysafflor yellow A (HSYA) specific safflower emerging medication treating wide range diseases. Hence, progress been made study an excellent example regulation recent years. Here, we on understanding main at level, summarize various types contents, with particular focus flavonoids. This aims provide insight into regulatory from perspective genomics.

Язык: Английский