Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 453 - 482
Опубликована: Дек. 13, 2024
Gastrointestinal
tract
harbours
a
very
complex
and
dynamic
community
of
microorganisms
known
as
the
'gut
microbiota'.
These
microbes
are
involved
in
various
critical
physiological
processes,
including
digestion
biomolecules,
synthesis
vitamins,
modulation
immune
system,
protection
against
pathogens.
This
chapter
provides
comprehensive
overview
gut
brain
axis.
The
delves
into
role
microbial
metabolites
like
short
chain
fatty
acids,
tryptophan
bile
acids
neuronal
neurotransmitter
functioning.
Cytokine
release
system
activation
can
potentially
change
microbiota
composition.
psychological
stress
reducing
beneficial
bacteria
increasing
pathogenic
composition
has
been
detailed.
Psychological
lead
to
these
consequences
by
altering
permeability
intestinal
cells.
effect
compromised
on
health
through
altered
activity
discussed.
The Egyptian Journal of Neurology Psychiatry and Neurosurgery,
Год журнала:
2024,
Номер
60(1)
Опубликована: Окт. 14, 2024
Abstract
Background
Schizophrenia
is
a
complex
neuropsychiatric
disorder
with
various
etiologic
factors.
Aberrant
levels
of
neurotransmitters
or
growth
factors
such
as
dopamine,
serotonin,
and
BDNF
have
been
shown
to
cause
cognitive
impairment
in
schizophrenia.
Recently,
the
gut
microbiome
has
also
suggested
factor
development
disorder.
To
explore
this
potential
link,
we
conducted
pilot
study
examine
relationship
between
plasma
Shotgun
metagenome
sequencing
total
RNA
from
fecal
samples
were
used
profile
schizophrenia
patients
(SCZ)
healthy
controls
(HC).
The
MetaPhlAn2
HUMaN2
pipelines
for
bioinformatic
analyses.
ELISA
was
measure
BDNF.
Spearman’s
rank
correlation
coefficient
analysis.
Results
We
found
that
butyrate-producing
bacteria
enriched
HC,
whereas
succinate-producing
bacteria,
namely
Phascolarctobacterium
succinatutens
Paraprevotella
clara
,
SCZ.
microbiota
SCZ
lipid
biosynthesis
pathways
related
bile-resistant
phospholipid
linked
HC.
Alistipes
indistinctus
Dorea
longicatena
Roseburia
inulinivorans
negatively
correlated
dopamine
levels.
intestinalis
Parabacteroides
goldsteini
serotonin
levels,
respectively.
significant
super-pathway
purine
deoxyribonucleoside
degradation.
Conclusions
This
provides
further
support
could
modulate
neurotransmitter
results
suggest
microbiome-targeted
therapies
may
help
rebalance
offering
new
hope
treatment
Applied Microbiology,
Год журнала:
2024,
Номер
4(4), С. 1642 - 1660
Опубликована: Дек. 10, 2024
Anorexia
nervosa
(AN)
is
a
psychiatric
illness
with
harmful
physical
consequences.
Studies
have
observed
differences
in
the
faecal
microbiota
of
patients
AN
compared
to
healthy
controls.
Diet
has
an
impact
on
gut
microbiota,
facilitating
altered
community,
such
changes
could
gut–brain
axis.
In
this
study,
three-stage
model
system
that
mimics
luminal
microbiology
large
intestine
was
conducted
identify
relationships
between
diet
and
microbiota.
A
microbial
medium
developed
provide
nutrients
more
appropriate
restricting
subtype
(R-AN).
The
inoculated
faeces
samples
were
taken
compare
end
products
following
fermentation
control
(HC)
R-AN
medium.
Then,
16S
amplicon
sequencing
along
flow
cytometry–fluorescence
situ
hybridisation
used
ascertain
Gas
chromatography
(GC)
assess
metabolites.
There
reduced
levels
SCFA
media
led
fewer
total
bacteria
numbers,
less
bifidobacteria
Rumincoccus
proximally,
but
Clostridium
Enterobacteriaceae.
Nutrient-deficient
resulted
neurotransmitter-producing
bacteria,
butyrate-producing
increased
protein-utilising
all
which
be
maintaining
factors
AN.
provides
novel
tool
for
exploring
how
extreme
dietary
therefore
useful
assessing
targeted
treatments.
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 453 - 482
Опубликована: Дек. 13, 2024
Gastrointestinal
tract
harbours
a
very
complex
and
dynamic
community
of
microorganisms
known
as
the
'gut
microbiota'.
These
microbes
are
involved
in
various
critical
physiological
processes,
including
digestion
biomolecules,
synthesis
vitamins,
modulation
immune
system,
protection
against
pathogens.
This
chapter
provides
comprehensive
overview
gut
brain
axis.
The
delves
into
role
microbial
metabolites
like
short
chain
fatty
acids,
tryptophan
bile
acids
neuronal
neurotransmitter
functioning.
Cytokine
release
system
activation
can
potentially
change
microbiota
composition.
psychological
stress
reducing
beneficial
bacteria
increasing
pathogenic
composition
has
been
detailed.
Psychological
lead
to
these
consequences
by
altering
permeability
intestinal
cells.
effect
compromised
on
health
through
altered
activity
discussed.
