Association between serum oxidative stress indicators, inflammatory indicators and suicide attempts in adolescents with major depressive disorder DOI Creative Commons
Peng Cao, Mengting Xu, Meng Ye

и другие.

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Фев. 24, 2025

Progress in research on the neurobiology of suicide behavior adolescents has notably lagged compared to that adults. This study aimed investigate associations between serum indicators, including oxidative stress (OS) and inflammatory psychological factors with attempts (SA) major depressive disorder (MDD) while also exploring potential markers. involved assessment 106 first-time hospitalized aged 12 18 MDD measurement indicators. Participants were categorized into two groups according their history SA within preceding six months. Screening best markers for by machine learning algorithms. Multivariable logistic regression was used assess correlation these indicators suicide. Secondly, Mendelian randomization (MR) initially explore causal relationship In diagnosed MDD, those who had attempted exhibited elevated superoxide dismutase (SOD) activity, reduced nitric oxide (NO) levels, more severe anxiety symptoms, worse sleep quality, increased exposure adverse life events, less effective coping strategies, parental attachment, alexithymia, impulsivity when counterparts without a (all p<0.05). The multivariable analyses showed significant association SOD activity (OR 1.254, 95% CI 1.043-1.534) symptoms 1.056, 1.020-1.097) MDD. MR genetically determined low uric acid (UA) levels higher risk 0.942 95%CI 0.896-0.991). Serum UA may be intent

Язык: Английский

Association between serum oxidative stress indicators, inflammatory indicators and suicide attempts in adolescents with major depressive disorder DOI Creative Commons
Peng Cao, Mengting Xu, Meng Ye

и другие.

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Фев. 24, 2025

Progress in research on the neurobiology of suicide behavior adolescents has notably lagged compared to that adults. This study aimed investigate associations between serum indicators, including oxidative stress (OS) and inflammatory psychological factors with attempts (SA) major depressive disorder (MDD) while also exploring potential markers. involved assessment 106 first-time hospitalized aged 12 18 MDD measurement indicators. Participants were categorized into two groups according their history SA within preceding six months. Screening best markers for by machine learning algorithms. Multivariable logistic regression was used assess correlation these indicators suicide. Secondly, Mendelian randomization (MR) initially explore causal relationship In diagnosed MDD, those who had attempted exhibited elevated superoxide dismutase (SOD) activity, reduced nitric oxide (NO) levels, more severe anxiety symptoms, worse sleep quality, increased exposure adverse life events, less effective coping strategies, parental attachment, alexithymia, impulsivity when counterparts without a (all p<0.05). The multivariable analyses showed significant association SOD activity (OR 1.254, 95% CI 1.043-1.534) symptoms 1.056, 1.020-1.097) MDD. MR genetically determined low uric acid (UA) levels higher risk 0.942 95%CI 0.896-0.991). Serum UA may be intent

Язык: Английский

Процитировано

0