International Journal of Community Medicine and Public Health,
Год журнала:
2023,
Номер
10(12), С. 4988 - 4992
Опубликована: Ноя. 8, 2023
Periodontal
diseases
primarily
occur
due,
to
infections
and
inflammation
that
affect
the
gums
bone
structures
supporting
teeth.
In
stage,
known
as
gingivitis
may
become
swollen
turn
red
bleed
easily.
These
health
issues
not
impact
but
also
have
broader
implications
for
overall
well-being,
including
tooth
loss,
discomfort,
bad
breath
an
increased
vulnerability,
chronic
illnesses.
The
main
objective
of
this
review
is
examine
aspects
pertaining
encompassing
clinical
indications,
methods,
diagnosis,
available
treatment
choices,
preventive
strategies.
This
research
meticulously
examines
types
these
diseases,
their
stages,
causes.
It
discusses
approaches
criteria
used
diagnose
conditions.
Additionally,
paper
provides
evaluation
alternatives
strategic
frameworks,
managing
pathologies.
includes
both
surgical
approaches,
well
supportive
therapies.
emphasizes
importance
measures.
Maintaining
oral
through
consistent
dental
hygiene
practices,
regular
checkups,
necessary
lifestyle
adjustments.
conclusion,
while
periodontal
pose
challenges
in
practice
they
can
be
controlled
prevented
collaboration,
between
practitioners,
hygienists,
active
patient
participation.
Oral Diseases,
Год журнала:
2023,
Номер
30(1), С. 23 - 37
Опубликована: Июнь 19, 2023
Abstract
Salivary
biomarkers
can
improve
the
efficacy,
efficiency,
and
timeliness
of
oral
maxillofacial
disease
diagnosis
monitoring.
Oral
conditions
in
which
salivary
have
been
utilized
for
disease‐related
outcomes
include
periodontal
diseases,
dental
caries,
cancer,
temporomandibular
joint
dysfunction,
gland
diseases.
However,
given
equivocal
accuracy
during
validation,
incorporating
contemporary
analytical
techniques
biomarker
selection
operationalization
from
abundant
multi‐omics
data
available
may
help
performance.
Artificial
intelligence
represents
one
such
advanced
approach
that
optimize
potential
to
diagnose
manage
Therefore,
this
review
summarized
role
current
application
based
on
artificial
discovery
validation
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 3945 - 3945
Опубликована: Апрель 22, 2025
Chronic
psychological
stress
is
known
to
influence
immune
function
and
contribute
development
of
autoimmune
disorders
through
dysregulated
inflammatory
responses.
This
study
investigates
relationships
between
acute
stress,
life
trauma,
salivary
biomarkers
in
firefighter
recruits
during
psychophysical
training.
Salivary
samples
were
collected
from
two
tests
evaluate
responses
stress.
Samples
obtained
at
three
time
points—pre-stress,
post-stress,
recovery—across
both
tests.
Cortisol
was
measured
characterize
response
(ASR)
profiles,
while
assessed
the
analyzing
C-reactive
Protein
(CRP),
Complement
C4
(C4),
Pigment
Epithelium
Derived
Factor
(PEDF),
Serum
Amyloid
P
(SAP).
Results
showed
significant
changes
CRP,
C4,
PEDF
after
inoculation.
Higher
previous
trauma
associated
with
lower
baseline
cortisol
(r
=
−0.489)
delay
recovery
0.514),
suggesting
a
learned
biological
response,
potentially
protective
against
stress-induced
dysregulation.
Cluster
analysis
revealed
four
distinct
ASR
profiles
which
found
have
significantly
different
past
(p
0.031).
These
findings
suggest
that
history
influences
biomarker
dynamics,
reflecting
individualized
adaptive
or
maladaptive
The
insights
gained
may
inform
strategies
enhance
resilience
mitigate
risk
among
high-stress
populations.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 10, 2024
Intervertebral
disc
degeneration
(IVDD)
is
one
of
the
most
prevalent
causes
chronic
low
back
pain.
The
role
m6A
methylation
modification
in
remains
unclear.
We
investigated
immune-related
regulators
as
IVDD
biomarkers
through
comprehensive
analysis
and
experimental
validation
degeneration.
training
dataset
was
downloaded
from
GEO
database
analysed
for
differentially
expressed
immunological
features,
were
subsequently
validated
by
a
rat
model
RT-qPCR.
Further
screening
key
based
on
machine
learning
LASSO
regression
analysis.
Thereafter,
predictive
constructed
sets,
which
set.
patients
then
clustered
expression
regulators,
immune
infiltrates
between
clusters
to
determine
markers
IVDD.
Finally,
we
potential
marker
enrichment
analysis,
protein-to-protein
network
molecular
prediction.
By
analysising
set,
revealed
significant
differences
gene
five
including
RBM15,
YTHDC1,
YTHDF3,
HNRNPA2B1
ALKBH5,
while
finding
characteristic
infiltration
genes,
result
PCR.
screen
differential
set
identified
RBM15
YTHDC1
regulators.
used
construct
successfully
it
Next,
explored
characteristics
well
clusters.
finally
an
biomarker
found
that
may
influence
microenvironment
ABL1
TXK.
In
summary,
our
results
suggest
development
provide
new
insights
precise
prevention
treatment
Journal of Trauma and Acute Care Surgery,
Год журнала:
2023,
Номер
95(4), С. 535 - 541
Опубликована: Май 11, 2023
Multiple
studies
have
demonstrated
that
human
neurobiology
and
behavior
are
inextricably
linked
to
the
activity
of
our
immune
systems.
Trauma
is
associated
with
a
multitude
system
changes;
reflecting
this,
posttraumatic
stress
disorder
(PTSD)
often
comorbid
immune-related
conditions
such
as
autoimmune
disorders.
To
further
investigate
this
phenomenon,
we
tested
hypothesis
cytokine
fluctuations
during
after
an
acute
response
correlates
experienced
life
trauma.Using
prospective
observational
approach,
cohort
study
measured
biomarker
profiles
in
firefighter
participants
(n
=
63),
9
having
prior
PTSD
diagnoses
54
without
diagnoses.
In
addition,
trauma
scores
were
determined
from
all
using
Life
Events
Checklist
5
(LEC-5)
survey.
Baseline
salivary
concentrations
determined,
along
levels
immediately
before,
after,
1
hour
following
standardized
stressful
training
event.
Biomarkers
these
samples
included
42
cytokines
6
steroid
thyroid
hormones.
The
markers
then
correlated,
Pearson
correlation
coefficients,
participants'
LEC-5
scores.
t
Tests
also
performed
compare
values
between
populations
diagnosis.Included
panel
interleukin
(IL)-8,
IL-10,
IL-1B,
GCSF,
IL1-Ra,
Groα,
IFNa2,
PDGFAA,
VEGF,
which
positive
at
various
time
points
individuals
increased
severity
(and
thus
trauma).
Concentrations
IL-1a,
Mip1a,
IL-6,
Mip1b,
TNFα,
TGFα
found
be
significantly
altered
diagnoses,
demonstrating
some
overlap
correlations.The
results
support
demonstrate
indeed
correlated
surrounding
test.Diagnostic
or
Criteria;
Level
IV.
Journal of Trauma and Acute Care Surgery,
Год журнала:
2023,
Номер
95(5), С. 664 - 671
Опубликована: Июнь 19, 2023
Frequent
exposure
to
acute
stress
increases
risk
of
suicide,
posttraumatic
disorder,
and
other
stress-related
disorders.
Neuroendocrine
immunologic
dysregulation
associated
with
may
underlie
predispositions
psychological
disorders
inflammatory
disease
processes
in
individuals,
such
as
first-responders
healthcare
professionals,
who
function
high
situations.
The
Hardiness
Resilience
Gauge
(HRG)
can
be
used
psychometrically
measure
resilience,
a
modifier
the
response.
Using
HRG
alongside
salivary
biomarker
profiling,
help
identify
low
resilience
phenotypes
allow
mitigation
early
therapeutic
interventions.
There
is
paucity
knowledge
regarding
biomarkers
resilience.
This
study
aims
evaluate
relationship
between
factors
levels
fluctuations
during
following
stress.Sixty-three
first
responders
underwent
standardized
stress-inducing
training
exercise,
providing
samples
before
(prestress),
immediately
after
(post-stress),
1
hour
event
(recovery).
was
administered
(initial)
(final)
event.
Multiplex
ELISA
panels
quantified
42
cytokines
6
hormones
from
samples,
which
were
analyzed
for
relationships
psychometric
measured
by
HRG.Several
correlated
scores
(
p
<
0.05)
select
set
moderate-to-strong
correlations
(|r|
>
0.3).
These
included
EGF,
GROα,
PDGFAA,
TGFα,
VEGFA,
interleukin
(IL)1Ra,
TNFα,
IL18,
cortisol,
FGF2,
IL13,
IL15,
IL6.
Interestingly,
PDGFAA
post-stress
compared
recovery
positively
negatively
pre-stress
period.This
exploratory
analysis
discovered
small
subset
that
are
significantly
Further
investigation
their
specific
roles
associations
resiliency
warranted.
Brain Sciences,
Год журнала:
2024,
Номер
14(5), С. 492 - 492
Опубликована: Май 13, 2024
Once
thought
of
as
an
immune-privileged
site,
we
now
know
that
the
nervous
system
communicates
in
a
bidirectional
manner
with
immune
via
neuroimmune
axis.
Neuropeptides
constitute
component
this
axis,
playing
critical
roles
brain
and
periphery.
The
function
salivary
neuropeptides
acute
stress
response
is
not
well
understood.
purpose
study
to
investigate
neuropeptide
levels
during
stress.
Salivary
samples
were
collected
from
fire
recruits
engaged
training
exercise
previously
shown
induce
stress,
at
three
separate
timepoints
oxytocin,
neurotensin,
Substance
P,
α-MSH,
β-Endorphin
measured
using
Human
Neuropeptide
5-Plex
Custom
Assay
Eve
Technologies.
All
increased
throughout
simulation
recovery
phase.
Exploratory
factor
analysis
(EFA)
identified
one
contributing
baseline
values
across
five
Pairwise
Pearson
Correlation
Coefficient
showed
positive
correlations
>0.9
for
almost
all
combinations
pre-stress
timepoint.
Further
negative
between
past-life
trauma
self-assessed
hardiness,
respectively.
Calculated
scores
overall
correlation
hardiness.
Altogether,
our
results
suggest
increase
synchronously
higher
correlate
required
determine
if
interventions
designed
enhance
activity
can
resilience,
especially
high-stress
occupations
such
firefighting.
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2519 - 2519
Опубликована: Ноя. 4, 2024
The
cortisol
awakening
response
(CAR)
is
a
pivotal
component
of
the
body's
stress
response,
yet
its
dynamics
under
repeated
acute
and
interplay
with
immune
biomarkers
remain
inadequately
understood.
American Journal of Disaster Medicine,
Год журнала:
2024,
Номер
19(1), С. 33 - 43
Опубликована: Фев. 1, 2024
Objective:
The
objective
of
this
study
was
to
investigate
possible
immune
cytokine
trends
throughout
a
week-long
surgical
simulation
mass-casualty
training
session
in
order
determine
the
effects
stress
inoculation
on
system.
Methods:
Thirty-seven
military
medical
students
participated
hyper-realistic
event
conducted
at
Strategic
Operations
site
San
Diego,
California.
Salivary
samples
were
collected
every
morning
exercise
for
4
consecutive
days.
Cortisol,
along
with
panel
42
cytokines,
measured
using
multiplex
enzyme-linked
immunosorbent
assays
from
Eve
Technologies.
determined
concentrations
averaged
and
plotted
scatter
plot,
then
points
fit
second-order
polynomial
trendline
best
measure.
Results:
cytokines
epidermal
growth
factor,
growth-related
oncogene-α,
interleukin
(IL)-1α,
platelet-derived
factor-AA
followed
noted
pattern
cortisol
decrease
week.
In
addition,
IL-27,
granulocyte
colony
stimulating
IL-10,
IL-13
demonstrated
late
peak,
by
return
baseline
conclusion
training.
Finally,
monocyte
chemoattractant
protein-1
displayed
decline
week
an
increase
last
day
training.
Conclusions:
Altogether,
these
results
help
identify
important
biomarkers
that
may
improve
long-term
adaptation
prevent
post-traumatic
disorder
following
exposure
repeated
stress.
