Unravelling the role of Interleukin-12 in Neuroinflammatory mechanisms: Pathogenic pathways linking Neuroinflammation to neuropsychiatric disorders
International Immunopharmacology,
Год журнала:
2025,
Номер
156, С. 114654 - 114654
Опубликована: Апрель 27, 2025
Язык: Английский
Post-traumatic stress disorder in individuals who required hospitalization for COVID-19: A cross-sectional study
ABCS Health Sciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 18, 2024
Introduction:
Currently,
the
physical
and
functional
consequences
on
individuals
who
have
recovered
from
severe
form
of
Covid-19
are
experiencing
traumatic
stress
remain
unknown.
Objective:
To
assess
post-traumatic
disorder
(PTSD)
in
post-hospital
discharge
following
COVID-19
investigate
its
relationship
with
sociodemographic
variables,
quality
life,
muscle
strength
capacity.
Methods:
A
cross-sectional
study
was
conducted,
including
both
genders
aged
between
31
79
years,
had
required
hospitalization.
Participants
underwent
evaluations
for
PTSD,
activity
level,
mobility
balance
(Timed
Up
Go
test
–
TUG),
distance
covered
6-minute
walk
(6MWT)
life
(Short
Form-36
Health
Srvey
-SF-36).
Results:
Out
153
eligible
individuals,
60
successfully
completed
assessments.
The
age
range
to
77
63.3%
were
female.
PTSD
identified
48.3%,
38.7%
exhibiting
partial
symptoms.
Furthermore,
65.5%
obese,
62.1%
hypertensive.
This
group
demonstrated
a
higher
degree
sedentary
behavior
(p=0.009),
increased
frequency
intensive
care
unit
hospitalization,
greater
number
days
hospitalized,
respectively
(p<0.001
p=0.010).
They
exhibited
longer
times
TUG
(p=0.014),
shorter
distances
than
predicted
6MWT
(p=0.001),
reduction
all
domains
SF-36.
Conclusion:
Given
findings
this
study,
follow-up
these
needs
be
continued
order
verify
permanence
symptoms
manifestations.
Язык: Английский
Trastornos neuropsiquiátricos asociados al Covid persistente
Revista Hospital Clínico Universidad de Chile,
Год журнала:
2024,
Номер
35(3), С. 197 - 210
Опубликована: Дек. 17, 2024
Persistent
COVID
(PC)
is
the
term
used
to
describe
a
multisystemic
and
multifactorial
entity,
which
follows
acute
SARS-CoV-2
infection.
Symptoms
must
persist
for
three
months
or
more
define
this
disorder.
The
clinical
manifestations
are
variable
nonspecific,
but
have
great
impact
on
quality
of
life
patients.
Neuropsychiatric
symptoms
commonly
reported
in
CP,
mostly
chronic
fatigue,
cognitive
disorders,
attention
among
others.
pathophysiological
mechanisms
not
fully
known,
most
described
hypoxia
related
neuronal
damage,
microvascular
lesions,
persistent
proinflammatory
state,
activation
latent
viral
infections,
alteration
blood-brain
barrier.
There
no
specific
complementary
tests
confirm
diagnosis
CP.
also
treatment
date
therapies
aimed
at
relieving
improving
life.
This
article
provides
comprehensive
bibliographic
review
common
neuropsychiatric
including
its
probable
proposed
date.
Язык: Английский