Neurobiology of Stress,
Год журнала:
2023,
Номер
28, С. 100597 - 100597
Опубликована: Дек. 6, 2023
Dominance
status
has
extensive
effects
on
physical
and
mental
health,
an
individual's
relative
position
can
be
shaped
by
experiential
factors.
A
variety
of
considerations
suggest
that
the
experience
behavioral
control
over
stressors
should
produce
winning
in
dominance
tests
blunt
impact
later
stressors,
as
does
prior
control.
To
investigate
interplay
between
competitive
success
stressor
control,
we
first
examined
controllability
subsequent
performance
a
warm
spot
competition
test
modified
for
rats.
Prior
controllable,
but
not
physically
identical
uncontrollable,
stress
increased
effortful
behavior
occupation
spot.
Controllable
subjects
consistently
ranked
higher
than
did
uncontrollable
subjects.
Pharmacological
inactivation
prelimbic
(PL)
cortex
during
prevented
facilitation
dominance.
Next,
explored
whether
repeated
experiences
produced
resistance
against
typical
sequelae
stress.
establish
status,
triads
rats
were
given
five
sessions
competition.
The
development
stable
was
reversible
PL
or
NMDA
receptor
blockade
dorsomedial
striatum.
Stable
blunted
stress-induced
increase
dorsal
raphe
nucleus
serotonergic
activity,
well
social
avoidance.
In
contrast,
endocrine
neuroimmune
responses
to
unaffected,
indicating
selective
Together,
these
data
demonstrate
instrumental
promotes
dominance,
also
reveal
buffer
neural
outcomes
future
adversity.
Journal of Clinical Investigation,
Год журнала:
2024,
Номер
134(16)
Опубликована: Авг. 14, 2024
Stress
has
long
been
associated
with
substance
misuse
and
use
disorders
(SUDs).
The
past
two
decades
have
seen
a
surge
in
research
aimed
at
understanding
the
underlying
mechanisms
driving
this
association.
This
Review
introduces
multilevel
"adaptive
stress
response"
framework,
encompassing
baseline,
acute
reaction,
recovery
return-to-homeostasis
phase
that
occurs
varying
response
times
across
domains
of
analysis.
It
also
discusses
evidence
showing
disruption
adaptive
context
chronic
repeated
stressors,
trauma,
adverse
social
drug-related
environments,
as
well
drug
withdrawal
abstinence
sequelae.
Subjective,
cognitive,
peripheral,
neurobiological
disruptions
phases
their
link
to
inflexible,
maladaptive
coping;
increased
craving;
relapse
risk;
maintenance
intake
are
presented.
Finally,
prevention
treatment
implications
targeting
"stress
pathophysiology
addiction"
discussed,
along
specific
aspects
may
be
targeted
intervention
development
rescue
stress-related
alterations
motivation
improve
SUD
outcomes.
The American Journal of Drug and Alcohol Abuse,
Год журнала:
2025,
Номер
unknown, С. 1 - 9
Опубликована: Март 12, 2025
Background:
Females
remain
underrepresented
in
opioid
use
disorder
(OUD)
research,
particularly
regarding
dorsal
striatal
neuroadaptations.
Chaperonins
seem
to
play
a
role
opioid-induced
neural
plasticity,
yet
their
contribution
OUD-related
changes
the
striatum
(DS)
remains
poorly
understood.
Given
known
sex
differences
sensitivity,
it
is
important
determine
how
chaperonin
expression
contributes
adaptations
females.
Frontiers in Human Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Янв. 24, 2024
The
context
surrounding
vocal
communication
can
have
a
strong
influence
on
how
signals
are
perceived.
serotonergic
system
is
well-positioned
for
modulating
the
perception
of
according
to
context,
because
neurons
responsive
social
behavior,
and
innervate
auditory
regions.
Animals
like
lab
mice
be
excellent
models
exploring
serotonin
affects
primary
neural
systems
involved
in
perception,
including
within
central
regions
inferior
colliculus
(IC).
Within
IC,
activity
reflects
not
only
presence
conspecific,
but
also
valence
given
interaction.
To
assess
whether
male
mice,
we
manipulated
systemically
with
an
injection
its
precursor
5-HTP,
locally
IC
infusion
fenfluramine,
reuptake
blocker.
Mice
then
participated
behavioral
assay
which
males
suppress
their
ultrasonic
vocalizations
(USVs)
response
playback
female
broadband
(BBVs),
used
defensive
aggression
by
females
when
interacting
males.
Both
5-HTP
fenfluramine
increased
suppression
USVs
during
BBV
relative
controls.
additionally
decreased
baseline
production
specific
type
USV
investigation,
neither
drug
treatment
strongly
affected
digging
or
grooming.
These
findings
show
that
modifies
responses
part
acting
brain
regions,
suggest
mouse
behavior
serve
as
useful
model
mechanisms
human
communication.
Trends in Neurosciences,
Год журнала:
2024,
Номер
47(9), С. 708 - 721
Опубликована: Авг. 9, 2024
Marked
dysregulation
of
the
human
prefrontal
cortex
(PFC)
and
anterior
cingulate
(ACC)
characterises
a
variety
anxiety
disorders,
its
amelioration
is
key
feature
treatment
success.
Overall
response,
however,
highly
variable,
about
third
patients
are
resistant
to
treatment.
In
this
review
we
hypothesise
that
major
contributor
variation
in
response
multiple
faces
induced
by
distinct
forms
frontal
dysregulation.
Comparison
findings
from
humans
non-human
primates
reveals
marked
similarity
functional
organisation
threat
regulation
across
lobes.
This
discussed
relation
'predatory
imminence
continuum'
model
differential
engagement
executive
functions
at
core
both
emotion
generation
strategies.
ALPHA PSYCHIATRY,
Год журнала:
2024,
Номер
25(3), С. 407 - 412
Опубликована: Авг. 2, 2024
To
study
the
clinical
effect
of
group
cognitive
behavioral
therapy
to
one-on-one
treatment
on
patients
with
early-onset
schizophrenia.
Totally,133
schizophrenia
admitted
Department
Psychiatry
our
hospital
from
September
2020
2023
were
selected
and
divided
into
a
control
an
observation
according
whether
was
performed.
The
general
demographic
data
collected,
propensity
score
matching
method
used
balance
baseline
2
groups.
Positive
negative
syndrome
scale,
Personal
Social
Performance
Scale,
severity
illness
(SI),
efficacy
index
(EI)
compared
between
groups
after
matching.
After
matching,
72
included
in
study.
Compared
group,
PANSS
decreased
including
intervention
(P
>
.05).
Both
showed
decrease
before
treatments.
Negative
Syndrome
Scale
reduction
rate
total
response
increased
<.001).
Clinical
Global
Impression
(CGI)
scores
higher
than
those
group.
In
CGI
scores,
there
is
significant
difference
that
SI
lower
=
.002),
while
EI
Group
beneficial
improvement
mental
symptoms
disease
severity,
social
function,
curative
effect,
which
advocated
popularized.
Cognitive Affective & Behavioral Neuroscience,
Год журнала:
2024,
Номер
24(1), С. 126 - 142
Опубликована: Янв. 10, 2024
A
recent
Cyberball
study
has
indicated
that
the
experience
of
loss
control
can
affect
how
people
process
subsequent
social
exclusion.
This
"preexposure
effect"
supports
idea
a
common
cognitive
system
involved
in
processing
different
types
threats.
To
test
validity
this
assumption
current
study,
we
reversed
sequence
preexposure
setup.
We
measured
effects
exclusion
on
utilizing
event-related
brain
potentials
(ERPs)
and
self-reports.
In
group
(CG,
n
=
26),
transition
to
elicited
significant
increases
both
P3
amplitude
self-reported
negative
mood.
Replicating
results
previous
these
were
significantly
reduced
by
an
independent
threat
(here:
exclusion).
contrast
findings,
not
modulated
discontinuation
(EG1disc,
25)
or
continuation
(EG2cont,
24)
threat.
Given
effect
is
related
violation
subjective
expectations,
support
notion
specific
widespread
individuals'
expectancy
upcoming
participation
control.
