Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2096 - 2096

Опубликована: Сен. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Язык: Английский

---

Therapeutic Candidates for Alzheimer’s Disease: Saponins

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 10505 - 10505

Опубликована: Июнь 22, 2023

Drug development for Alzheimer's disease, the leading cause of dementia, has been a long-standing challenge. Saponins, which are steroid or triterpenoid glycosides with various pharmacological activities, have displayed therapeutic potential in treating disease. In comprehensive review literature from May 2007 to 2023, we identified 63 references involving 40 different types saponins that studied their effects on These studies suggest ameliorate disease by reducing amyloid beta peptide deposition, inhibiting tau phosphorylation, modulating oxidative stress, inflammation, and antiapoptosis. Most intriguingly, ginsenoside Rg1 pseudoginsenoside-F11 possess these important properties show best promise treatment This provides summary classification common showcasing underlying mechanisms. highlights promising

Язык: Английский

---

Clinical Applications of Non-Invasive Brain Stimulation in Stroke Recovery: A Review of Current Evidence and Therapeutic Strategies

Current Treatment Options in Neurology, Год журнала: 2025, Номер 27(1)

Опубликована: Янв. 13, 2025

Язык: Английский

---

The Neural Mechanism Underlying Differentiated In-Group Versus Out-Group Face Recognition and Memory, Identification, Empathy and Pro-social Behavior: Evidence from fMRI and ERP Studies

Journal of Integrative Neuroscience, Год журнала: 2024, Номер 23(3)

Опубликована: Март 1, 2024

In the context of perceiving individuals within and outside social groups, there are distinct cognitive processes mechanisms in brain. Extensive research recent years has delved into neural that underlie differences how we perceive from different groups. To gain a deeper understanding these mechanisms, present comprehensive review perspectives facial recognition memory, intergroup identification, empathy, pro-social behavior. Specifically, focus on studies utilize functional magnetic resonance imaging (fMRI) event-related potential (ERP) techniques to explore relationship between brain regions Findings fMRI reveal associated with differentiation perception behavior do not operate independently but instead exhibit dynamic interactions. Similarly, ERP indicate amplitude responses shows various combinations relation

Язык: Английский

---

Subthreshold Depression: A Systematic Review and Network Meta-Analysis of Non-Pharmacological Interventions

Neuropsychiatric Disease and Treatment, Год журнала: 2023, Номер Volume 19, С. 2149 - 2169

Опубликована: Окт. 1, 2023

Background: Subthreshold depression (StD) is considered to be the "precursor" stage of major depressive disorder (MDD), which could cause higher risk suicide, disease burden and functional impairment. There have been various non-pharmacological interventions for StD. However, comparison their effectiveness still lacks sufficient evidence. We performed a systematic review network meta-analysis evaluate rank efficacy multiple targeting Methods: conducted thorough search across databases including PubMed, Medline, Embase, Web Science PsycINFO from inception December 2022. All included studies were randomized controlled trials (RCTs) patients with StD compared control group (CG). Several universal scales measuring severity used as outcomes. The surface under cumulative ranking curve (SUCRA) was separately each intervention using "Stata 17.0" software. Results: A total thirty-six included, involving twenty-eight 7417 participants. research found that most superior controls In outcome evaluation by different depression, psychotherapy always ranked first in terms treatment effectiveness, especially Problem-solving Therapy (PST), Behavioral Activation (BAT), Cognitive (CBT)/Internet-based CBT (I-CBT)/Telephone-based (T-CBT). Since groups not directly compared, optimal determined. Conclusion: Here, we show may better choice This study provides some evidence on management selection clinical workers. establish its effect more conclusively, content, format operators require extensive exploration conduct effective, convenient cost-effective implementation primary healthcare. Notably, further also urgently needed find biological neural mechanisms examining whether alters neuroplasticity Keywords: subthreshold intervention, efficacy, comparison, meta-analysis,

Язык: Английский

---