Does multimodal exercise reduce C-reactive protein levels in major depressive disorder? Preliminary results from a randomized controlled trial
Journal of Psychiatric Research,
Год журнала:
2025,
Номер
183, С. 252 - 259
Опубликована: Фев. 19, 2025
Язык: Английский
The Role of Estrogen across Multiple Disease Mechanisms
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(8), С. 8170 - 8196
Опубликована: Июль 29, 2024
Estrogen
is
a
significant
hormone
that
involved
in
multitude
of
physiological
and
pathological
processes.
In
addition
to
its
pivotal
role
the
reproductive
system,
estrogen
also
implicated
pathogenesis
diseases.
Nevertheless,
previous
research
on
diseases,
including
Alzheimer’s
disease,
depression,
cardiovascular
diabetes,
osteoporosis,
gastrointestinal
estrogen-dependent
cancers,
has
concentrated
single
disease
area,
resulting
lack
comprehensive
understanding
cross-disease
mechanisms.
This
brought
some
challenges
current
treatment
methods
for
these
because
as
potential
therapeutic
tool
not
yet
fully
developed
potential.
Therefore,
this
review
aims
comprehensively
explore
mechanism
seven
types
The
objective
study
describe
relationship
between
each
estrogen,
ways
which
participates
regulating
mechanisms,
outline
efficacy
treating
diseases
clinical
practice.
By
studying
variety
it
hoped
more
accurate
theoretical
basis
guidance
future
strategies
will
be
provided,
thus
promoting
effective
management
Язык: Английский
Individual and integrated indexes of inflammation predicting the risks of mental disorders - statistical analysis and artificial neural network
BMC Psychiatry,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 11, 2025
The
prevalence
of
mental
illness
in
Taiwan
increased.
Identifying
and
mitigating
risk
factors
for
is
essential.
Inflammation
may
be
a
factor
illness;
however,
the
predictive
power
inflammation
test
values
unclear.
Artificial
intelligence
can
predict
disease.
This
study
was
first
to
conduct
prediction
based
on
combination
individual
values.
A
retrospective
longitudinal
design
adopted
analyze
data
obtained
from
medical
center.
Patients
were
enrolled
if
they
had
received
blood
tests
inflammation.
Propensity
score
matching
employed
within-group
comparisons.
total
231,306
patients
enrolled.
deep
neural
network
model
establish
model.
Among
markers,
high-sensitivity
C-reactive
protein
concentrations
associated
with
greatest
(37.45%),
followed
by
(32.21%).
more
abnormal
participant's
were,
higher
(aHR
=
1.301,
p
<.001).
Specifically,
concentration
most
indicative
marker
predicting
illness.
markers
exhibited
certain
correlations
type
When
same
variables
considered,
statistical
analysis
similar
results.
After
feature
extraction
incorporated,
performance
improved
(excellent,
area
under
curve
0.9162)
could
effectively
developing
illnesses
general
types
Язык: Английский
Association between C-reactive protein-triglyceride glucose index and depressive symptoms in American adults: results from the NHANES 2005 to 2010
BMC Psychiatry,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 5, 2024
The
novel
serum
C-reactive
protein-triglyceride
glucose
index
(CTI)
has
been
identified
as
an
ideal
parameter
that
integrates
inflammation
and
insulin
resistance,
which
are
potential
mechanisms
underlying
depressive
symptoms.
Our
research
aimed
to
investigate
the
association
between
CTI
cross-sectional
investigation
utilized
data
from
National
Health
Nutrition
Examination
Survey
conducted
2005
2010.
integrated
was
calculated
0.412
×
Ln
(C-reactive
protein)
(mg/dL)
+
[triglyceride
fasting
(mg/dL)/2].
severity
of
symptoms
evaluated
through
continuous
Patient
Questionnaire-9
(PHQ-9)
scores,
categorical
definition
(PHQ-9
score
≥
10)
reflected
moderate
severe
Survey-weighted
linear
logistic
regression
models
were
establish
correlation
PHQ-9
Moreover,
subgroup
analyses,
interaction
tests,
smoothed
curve
fitting
performed
scrutinize
steadiness
results.
A
total
5,954
participants
enrolled
in
our
study,
including
477
with
5,477
without.
results
revealed
a
significant
positive
relationship
scores
(β:
0.40,
95%
CI:
0.25,0.55,
p
<
0.001)
(OR:
1.30,
1.06,1.61,
=
0.02).
Additionally,
individuals
fourth
quartile
exhibited
higher
likelihood
than
those
first
score:
β:
0.83,
0.39,1.26,
0.001;
symptoms:
OR:
2.00,
CI:1.19,3.36,
0.01).
Smooth
analyses
consistently
demonstrated
relationship.
Elevated
correlated
risk
symptoms,
underscoring
clinical
indicator
for
identifying
stratifying
Not
applicable.
Язык: Английский
Network analysis of depressive symptoms and C-reactive protein levels in major depressive disorder
Journal of Affective Disorders,
Год журнала:
2024,
Номер
367, С. 788 - 794
Опубликована: Авг. 24, 2024
Язык: Английский
Inflammation as a link between depression and metabolic syndrome
V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY,
Год журнала:
2024,
Номер
58(4-2), С. 8 - 19
Опубликована: Дек. 15, 2024
Depression
makes
a
major
contribution
to
the
overall
global
burden
of
disease,
including
increased
risk
wide
range
concomitant
somatic
pathology.
А
high
percentage
mortality
in
psychiatric
patients
is
attributed
physical
diseases,
mainly
cardiovascular
(CVD).
Metabolic
syndrome
(MetS)
one
factors
for
both
CVD
and
frequent
comorbid
depression.
The
purpose
this
review
systematize
data
on
relationship
between
MetS
depression,
particular,
shared
pathogenetic
mechanisms
as
systemic
inflammation.
manuscript
evaluates
issue
use
hematological
indices
inflammation
(HISIs)
diagnosis
affective
pathology,
also
provides
new
combined
indicators,
cellular
link
lipidogram
parameters.
latter
include
ratios
lymphocytes
high-density
lipoproteins
(HDL)
(Lymphocyte
To
High-Density
Lipoprotein
Ratio,
LHR),
neutrophils/HDL
(Neutrophil
NHR),
platelets/HDL
(Platelet
PHR)
monocytes/HDL
(Monocyte
High
Density
MHR).
Understanding
metabolic
with
depression
can
help
identify
individuals
at
timely
preventive
measures.
Various
clinical
trials
studies
indicate
parameters
syndrome,
but
question
choosing
most
effective
coefficients
remains
open.
Further
study
problem
potential
risks
disorders
perform
adequate
strategies.
Язык: Английский
Gender and activity disparities in the relationship between circadian syndrome and gallstone disease
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 23, 2024
Objective
To
explore
the
potential
correlation
between
gallstone
disease
(GSD)
prevalence
and
circadian
syndrome
(CircS).
Methods
The
cross-sectional
research
utilized
data
spanning
2017
to
March
2020,
sourced
from
National
Health
Nutrition
Examination
Survey
(NHANES).
GSD
were
collected
via
questionnaires,
with
appropriate
sample
weights
applied
ensure
study
population
was
representative.
Three
multivariable
logistic
regression
models
built
clarify
connection
CircS
GSD.
Furthermore,
subgroup
analysis
interaction
test
carried
out,
categorized
based
on
demographic
traits
lifestyle
aspects,
discern
influence
of
these
variables
correlation.
Results
included
4,126
participants,
a
38.68%
for
12.04%
indicated
positive
(Odds
Ratio
(OR)
=
1.336,
95%
Confidence
Interval
(CI):
1.048,
1.702).
When
stratified
by
number
components,
observed
components
(P
trend
<
0.05).
In
particular,
individuals
six
or
more
had
higher
than
those
three
fewer
(OR
2.608,
CI:
1.464,
4.647).
revealed
that
mainly
in
female
1.701,
1.236,
2.341)
not
engaged
moderate
activity
1.990,
1.158,
3.418).
Conclusion
There
is
prevalence,
particularly
among
females
engaging
activity.
These
findings
offer
new
insights
directions
may
impact
preventive
therapeutic
strategies.
Язык: Английский