Sex differences in the association between metabolic disorder and inflammatory cytokines in Han Chinese patients with chronic schizophrenia

Frontiers in Psychiatry, Год журнала: 2025, Номер 15

Опубликована: Янв. 3, 2025

Previous evidence suggests that immune-inflammatory dysfunction plays an important role in metabolic disorder (MD) of patients with schizophrenia, yet studies on sex differences the association between both are limited. The current study aimed to investigate MD and inflammatory cytokines Han Chinese chronic schizophrenia (CS). This multicentre cross-sectional was conducted one general hospital two psychiatric hospitals Anhui Province, China. General information, parameters cytokine indicators were collected from all participants, severity their symptoms assessed using Positive Negative Syndrome Scale (PANSS). A total 324 completed assessment included this study. had higher age duration illness, lower chlorpromazine equivalents negative symptom score than those without MD. Binary logistic regression showed significantly associated a IL-1β level male patients, while not significant females. Further multiple linear revealed negatively correlated polypharmacy only patients. Sex CS, is there correlation level. Sex-specific prevention intervention strategies may contribute reducing CS.

Язык: Английский

---

Ethical dilemmas in the care of patients suffering from psychotic catatonia: a case report

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Фев. 5, 2025

Background Coercive measures in psychiatric practice are controversial due to their potential for severe negative effects. Ethical debates focus on respecting autonomy, minimizing damaging effects, and acting the patient’s best interest. Case We present a unique case of young patient suffering from first episode catatonic psychosis, which striking this balance was especially difficult given complete mutism opposition, absence immediate danger herself or others, lack anamnestic information, her avoidance social support, would have meant that she not encountered care, were it an exceptional government plan place at time hospitalization. The showed very favorable, persistent response nonvoluntary treatment with haloperidol lorazepam, could be discussed debriefed once recovered, after almost 5 months hospitalization follow-up. Discussion Arguments against reviewed based discussion local ethics committee, providing useful reference future similar cases. Finally, highlights atypical onset psychosis previously high-functioning individual explores mental health impact international tensions, particularly Russian-Ukrainian war, individuals.

Язык: Английский

---

Ketogenic metabolic therapy for schizoaffective disorder: a retrospective case series of psychotic symptom remission and mood recovery

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Фев. 7, 2025

Schizoaffective disorder is a severe psychiatric condition characterized by mood disturbances and psychotic symptoms. Standard treatments, primarily pharmacological, often fail to control symptoms fully can lead significant metabolic side effects. Emerging evidence suggests that ketogenic therapy (KMT), also known as the diet, may offer powerful alternative conventional treatments for components resolve in patients with schizoaffective disorder. This case series investigates effects of KMT on two individuals diagnosed who pursued this due ineffectiveness treatments. Both presentations followed modified diet medical oversight. Symptom changes were assessed using validated tools, including Generalized Anxiety Disorder-7 (GAD-7), Depression Stress Scales (DASS-42), PTSD Checklist DSM-5 (PCL-5), Patient Health Questionnaire-9 (PHQ-9). experienced complete cessation improvements mood. Case 1, 17-year-old female, achieved full remission suicidal ideation, hallucinations, anxiety within 6 weeks, sustained at 24-week follow-up. 2, 32-year-old chronic months. Patients either deprescription or process time demonstrates disorder, leading functional recovery reported quality life extend beyond symptom standard care interventions.

Язык: Английский

---

Mental Illness Strikes at the Heart: Impact of Psychiatric Diseases on Ventricular Ejection Fraction in Patients with Acute Coronary Syndromes

Life, Год журнала: 2025, Номер 15(3), С. 340 - 340

Опубликована: Фев. 21, 2025

Mental illnesses can have a significant impact on individuals experiencing acute coronary syndromes (ACS). are associated with an increased cardiovascular risk profile and early onset of disease. A critical aspect this interplay is the effect psychiatric conditions left ventricular ejection fraction (LVEF), key parameter in evaluating cardiac function predicting long-term outcomes ACS patients. The present single-center, retrospective study investigated associations between function, focus LVEF inclusion criteria were Italian nationality 30 years or older. One hundred sixty-four patients without (Mage = 68.8 ± 10.6, 62 females) 161 diagnosis 68.4 13.7, 63 enrolled. data collected included sociodemographic variables, diagnoses, LVEF, type (STEMI/NSTEMI), smoking status, previous interventions, pharmacological treatments. Statistical analyses chi-square, t-tests, ANOVAs, ANCOVA to assess differences across groups. Findings revealed lower compared (p 0.004, d 0.36). Patients NSTEMI 0.047, φ 0.11), hypertension 0.003, −0.16), dyslipidemia 0.022, −0.13). In contrast, STEMI neurological dysfunction 0.014, 0.14), chronic obstructive pulmonary disease 0.010, 0.14). Among anxiety disorders substance abuse 0.012, −0.81). findings underscore complex relationship mental illness emphasising need integrate evaluations into cardiology care optimise management both health. This has several limitations, including its design, which prevents causal conclusions, use convenience sampling, limits generalizability findings.

Язык: Английский

---

Preliminary study on Cardiovascular and Biochemical Responses to Atypical and Typical Antipsychotic Medication in Schizophrenic Patients

Brain Disorders, Год журнала: 2025, Номер unknown, С. 100227 - 100227

Опубликована: Апрель 1, 2025

Язык: Английский

---

Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Июнь 4, 2024

Psychotic symptoms are among the most debilitating and challenging presentations of severe psychiatric diseases, such as schizophrenia, schizoaffective, bipolar disorder. A pathophysiological understanding intrinsic brain activity underlying psychosis is crucial to improve diagnosis treatment. While a potential continuum along psychotic spectrum has been recently described in neuroimaging studies, especially for what concerns absolute relative amplitude low-frequency fluctuations (ALFF fALFF), these efforts have given heterogeneous results. transdiagnostic meta-analysis ALFF/fALFF patients with compared healthy controls currently lacking. Therefore, this pre-registered systematic review PubMed, Scopus, Embase were searched articles comparing between controls. quantitative synthesis differences (f)ALFF was performed Seed-based d Mapping, adjusting age, sex, duration illness, clinical severity. All results corrected multiple comparisons by Family-Wise Error rates. lower ALFF fALFF detected comparison controls, no specific finding survived correction comparisons. Lack might explain discordant findings highlighted previous literature. Other explanations include methodological issues, lack standardization pre-processing or analytical procedures studies. Future research on should prioritize replicability individual Systematic registration https://osf.io/ , identifier (ycqpz).

Язык: Английский

---

Elevated serum IL-17 A and CCL20 levels as potential biomarkers in major psychotic disorders: a case-control study

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 11, 2024

Major psychotic disorders (MPD), including schizophrenia (SCZ) and schizoaffective disorder (SAD), are severe neuropsychiatric conditions with unclear causes. Understanding their pathophysiology is essential for better diagnosis, treatment, prognosis. Recent research highlights the role of inflammation immune system, particularly Interleukin 17 (IL-17) family, in these disorders. Elevated IL-17 levels have been found MPD, human A antibodies available. Changes chemokine levels, such as CCL20, also noted SCZ. This study investigates relationship between serum CCL20 MPD patients clinical characteristics. We conducted a case-control at Ibn Sina Psychiatric Hospital (Mashhad, Iran) 2023. The involved 101 participants, which 71 were 30 healthy controls (HC). Positive Negative Symptom Scale (PANSS) was utilized to assess symptoms patients. Serum measured using Enzyme-Linked Immunosorbent Assay (ELISA) kits. gathered data on lipid profiles Fasting Blood Glucose (FBS). mean age 41.04 ± 9.93 years. median significantly elevated compared HC (5.8 (4.1–15.3) pg/mL 4.2 (3–5) pg/mL, respectively; p < 0.001). Furthermore, showed positive correlation severity MPD. had higher FBS, cholesterol, Low-Density Lipoprotein (LDL) lower High-Density (HDL) HC. No significant PANSS components blood IL17 CCL20. current revealed that than those control group. Metabolic factors HDL, LDL differences In conclusion, findings suggest two inflammatory could serve potential therapeutic targets prognostic biomarkers schizophrenia.

Язык: Английский

---

Navigating complexity: healthcare providers’ experiences with integrating physical health promotion in psychosis outpatient services in Sweden

Nordic Journal of Psychiatry, Год журнала: 2024, Номер 78(8), С. 659 - 667

Опубликована: Сен. 17, 2024

Individuals with psychotic disorders face an increased risk of physical health issues, leading to reduced life expectancy. Despite recommendations integrate promotion into mental healthcare, challenges persist, and mortality from somatic diseases continues rise. Understanding healthcare providers' perspectives is crucial overcoming these barriers. This study aims explore the experiences providers working in direct patient care as unit heads regarding factors influencing Swedish psychosis outpatient units.

Язык: Английский

---

Acceptance and Commitment Therapy-based Lifestyle Counselling Program for people with early psychosis on physical activity: A pilot randomized controlled trial

Schizophrenia Research, Год журнала: 2024, Номер 275, С. 1 - 13

Опубликована: Ноя. 28, 2024

Язык: Английский

---

Mental Health Nurses’ Knowledge of Metabolic Syndrome: A Cross‐Sectional Study

Nursing Forum, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Background: Adequate knowledge of the metabolic syndrome is essential for mental health nurses as it enhances their ability to recognize and address physical needs individuals diagnosed with serious illnesses. Aims: This study investigated factors influencing level among nurses. Methods: A cross‐sectional was conducted 208 recruited from four hospitals in northern Taiwan, including two regional hospitals, one medical center, hospital. Nurses’ assessed using a validated 20‐item self‐administered questionnaire covering key aspects syndrome, pathophysiology, diagnostic criteria, management. The demonstrated satisfactory reliability (KR‐20 = 0.702) content validity. Data analysis involved descriptive statistics, independent t ‐tests, one‐way variance, Pearson correlation coefficient, generalized linear models identify predictors levels. Results: overall correct answer rate 60.1%. Generalized modeling that nurses’ significantly associated sources information ( B 1.371, 95% CI 0.458–2.285, p 0.003), type hospital they worked −1.027, −2.015 −0.039, 0.042), working community unit 1.975, 0.067–3.883, 0.042). Conclusions: Our results indicate possessed moderate concerning people illness. Addressing this gap requires targeted education programs integrate into psychiatric care promote use diverse, evidence‐based resources tailored specific different settings. Organizational efforts should focus on fostering supportive culture access high‐quality resources, encourages interdisciplinary collaboration, supports continuous professional development.

Язык: Английский

---