International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3498 - 3498
Опубликована: Апрель 8, 2025
Cytokine receptor-like factor 3 (CRLF3) has an extended evolutionary history, which been conserved across metazoan species. It consists of several structural elements, notably including a fibronectin type (FBNIII) domain containing WSXWS motif that is synonymous with so-called class I cytokine receptors present throughout bilaterial species, and proposed spl1 ryanodine receptor (SPRY) represents widespread protein–protein interaction module. The function CRLF3 remained enigmatic, but recent investigations have revealed critical insights into its biological roles. These studies suggest principally functions in neural hematopoietic cells, where it plays diverse roles the development specific cell populations. Disruption also associated human diseases, mainly these same lineages malignancy. mechanisms by exerts effects remain uncertain, although number potential options emerged.
Язык: Английский