Genomics & Informatics,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 27, 2025
Abstract
Background
Understanding
the
progression
and
recovery
process
of
COVID-19
is
crucial
for
guiding
public
health
strategies
developing
targeted
interventions.
This
longitudinal
cohort
study
aims
to
elucidate
dynamics
severity
evaluate
impact
underlying
conditions
on
these
transitions,
providing
critical
insights
more
effective
disease
management.
Methods
Data
from
4549
patients
admitted
Seoul
National
University
Boramae
Medical
Center
between
February
5th,
2020,
October
30th,
2021,
were
analyzed
using
a
5-state
continuous-time
Markov
multistate
model.
The
model
estimated
instantaneous
transition
rates
different
levels
severity,
predicted
probabilities
state
determined
hazard
ratios
associated
with
comorbidities.
Results
analysis
revealed
that
most
stabilized
in
their
initial
state,
72.2%
moderate
symptoms
remaining
moderate.
Patients
hypertension
had
67.6%
higher
risk
progressing
severe,
while
those
diabetes
an
89.9%
deteriorating
severe
critical.
Although
death
low
early
hospitalization,
comorbidities
significantly
increased
likelihood
worsening
conditions.
Conclusion
highlights
utility
models
assessing
among
hospitalized
patients.
findings
indicate
are
likely
recover
than
experience
However,
increase
outcomes,
underscoring
importance
managing
The Pediatric Infectious Disease Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Background:
This
systematic
review
sought
to
characterize
child-to-child
and
child-to-adult
transmission
of
severe
acute
respiratory
coronavirus
2
(SARS-CoV-2).
Methods:
A
was
conducted
from
April
1,
2021,
December
15,
2023,
estimate
secondary
attack
rates
(SARs)
infections
per
index
case
(case
rate)
cases
up
age
20
years.
SAR
rate
were
analyzed
based
on
age,
setting,
country
variant
prevalence.
Meta-analysis
the
data.
Results:
Eighty-six
studies
included,
representing
33,674
cases.
The
total
pooled
0.11
(95%
CI:
0.07–0.16);
0.05
0.03–0.10)
for
0.15
0.07–0.30)
transmission.
Pooled
in
households
0.28
0.24–0.34)
0.02
0.01–0.04)
schools.
Conclusions:
role
children
SARS-CoV-2
is
small,
particularly
work
can
help
inform
policies
that
effectively
reduce
while
minimizing
adverse
effects
children.
Community Health Equity Research & Policy,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
The
COVID-19
pandemic
had
a
negative
impact
on
populations
worldwide,
particularly
older
adults
residing
in
low
-
and
middle-income
countries.
Due
to
these
impacts,
non-governmental
organizations
(NGOs)
provided
extensive
support,
which
affected
their
operations.
Using
the
social
resilience
framework,
purpose
of
this
study
was
better
understand
what
strategies
NGOs
used
support
vulnerable
how
they
are
building
back
stronger
from
pandemic.
In
fall
2022,
26
(virtual)
in-depth
interviews
were
conducted
with
staff
volunteers
an
NGO
supporting
Uganda.
Several
key
themes
emerged
including
using
existing
resources
importance
having
multiple
sources
revenue
organizational
lessons
learned
by
can
be
utilized
enact
policy
practice
change
help
strengthen
NGOs'
resilience.
This
would
allow
them
continue
implementing
innovative
during
times
crisis.
Genomics & Informatics,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 27, 2025
Abstract
Background
Understanding
the
progression
and
recovery
process
of
COVID-19
is
crucial
for
guiding
public
health
strategies
developing
targeted
interventions.
This
longitudinal
cohort
study
aims
to
elucidate
dynamics
severity
evaluate
impact
underlying
conditions
on
these
transitions,
providing
critical
insights
more
effective
disease
management.
Methods
Data
from
4549
patients
admitted
Seoul
National
University
Boramae
Medical
Center
between
February
5th,
2020,
October
30th,
2021,
were
analyzed
using
a
5-state
continuous-time
Markov
multistate
model.
The
model
estimated
instantaneous
transition
rates
different
levels
severity,
predicted
probabilities
state
determined
hazard
ratios
associated
with
comorbidities.
Results
analysis
revealed
that
most
stabilized
in
their
initial
state,
72.2%
moderate
symptoms
remaining
moderate.
Patients
hypertension
had
67.6%
higher
risk
progressing
severe,
while
those
diabetes
an
89.9%
deteriorating
severe
critical.
Although
death
low
early
hospitalization,
comorbidities
significantly
increased
likelihood
worsening
conditions.
Conclusion
highlights
utility
models
assessing
among
hospitalized
patients.
findings
indicate
are
likely
recover
than
experience
However,
increase
outcomes,
underscoring
importance
managing
