Insights into the Enhanced Bioavailability of Per- and Polyfluoroalkyl Substances in Food Caused by Chronic Inflammatory Bowel Disease

Environmental Science & Technology, Год журнала: 2024, Номер 58(27), С. 11912 - 11922

Опубликована: Июнь 27, 2024

Understanding the bioavailability of per- and polyfluoroalkyl substances (PFAS) in food is essential for accurate human health risk assessment. Given rising incidence inflammatory bowel disease (IBD), this study aimed to investigate impacts IBD on PFAS using mice models. The relative (RBA) was highest chronic (64.3–144%), followed by healthy (60.8–133%) acute (41.5–121%), suggesting that enhanced exposure risk. In vitro tests showed intestinal micelle stability increased as a result reduced content short-chain fatty acids, thus promoting bioaccessibility digestive fluid IBD. Additionally, pathogenic decreased beneficial bacteria gut groups facilitated permeability, enhancing absorption. These together explained higher RBA However, remarkably lower enzymatic activities suggested severely impaired ability IBD, which excretion from feces, lowering RBA. Conversely, might exacerbate changing microbiota structures. This hints individuals with inflammation have than population.

Язык: Английский

---

Global Burden of Inflammatory Bowel Disease Among Children and Adolescents: A Comprehensive Analysis (1990–2019)

International Journal of Public Health, Год журнала: 2024, Номер 69

Опубликована: Сен. 9, 2024

Язык: Английский

---

Effect of Ward-Noise-Reduction Management on the Mental Health and Quality of Life of Patients with Inflammatory Bowel Disease

Noise and Health, Год журнала: 2024, Номер 26(121), С. 174 - 179

Опубликована: Апрель 1, 2024

This study aimed to explore the effect of ward-noise-reduction management on mental health and quality life patients with inflammatory bowel disease.

Язык: Английский

---

Lipid- and polymer-based formulations containing TNF-α inhibitors for the treatment of inflammatory bowel diseases

Drug Discovery Today, Год журнала: 2024, Номер 29(8), С. 104090 - 104090

Опубликована: Июль 6, 2024

Monoclonal antibodies inhibiting tumor necrosis factor-alpha (iTNF-α) have revolutionized the therapeutic regimen of inflammatory bowel disease, but their main drawback is parenteral route administration they require. An alternative approach lies in delivery these molecules to area involved process by means innovative formulations able promote localization affected tissues while also decreasing number administrations required. This review describes advantages deriving from use lipid- and polymer-based systems containing iTNF-α, focusing on physicochemical technological properties discussing preclinical results obtained vivo using rodent models colitis.

Язык: Английский

---

Clinical characteristics and long

PubMed, Год журнала: 2023, Номер 48(6), С. 852 - 858

Опубликована: Июнь 28, 2023

With the increase in aging population China, elderly Crohn's disease (CD) patients need to receive more attention. This study aims explore clinical characteristics and process of onset CD (EOCD) a single center.

Язык: Английский

---