Zanidatamab for HER2-amplified, unresectable, locally advanced or metastatic biliary tract cancer (HERIZON-BTC-01): a multicentre, single-arm, phase 2b study

The Lancet Oncology, Год журнала: 2023, Номер 24(7), С. 772 - 782

Опубликована: Июнь 2, 2023

Язык: Английский

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Burden of digestive system diseases in China and its provinces during 1990–2019: Results of the 2019 Global Disease Burden Study

Chinese Medical Journal, Год журнала: 2024, Номер unknown

Опубликована: Авг. 14, 2024

Evaluating the impact of digestive system diseases is vital for devising effective prevention strategies. However, comprehensive reports on burden in China are lacking. Our study aimed to provide an overview and trends from 1990 2019 its provinces.

Язык: Английский

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Burden of Gastrointestinal Tumors in Asian Countries, 1990–2021: An Analysis for the Global Burden of Disease Study 2021

Clinical Epidemiology, Год журнала: 2024, Номер Volume 16, С. 587 - 601

Опубликована: Сен. 1, 2024

Gastrointestinal tumors represent a significant component of the cancer burden in Asia. This study aims to evaluate gastrointestinal Asia from 1990 2021 using data Global Burden Disease Study (GBD 2021).

Язык: Английский

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Spatiotemporal Patterns of Esophageal Cancer Burden Attributable to Behavioral, Metabolic, and Dietary Risk Factors From 1990 to 2019: Longitudinal Observational Study

JMIR Public Health and Surveillance, Год журнала: 2023, Номер 9, С. e46051 - e46051

Опубликована: Сен. 5, 2023

Esophageal cancer (EC) is the sixth leading cause of cancer-related burden with distinct regional variations globally. Although EC has decreased, specific reasons for this decline are still unclear.This study aims to uncover spatiotemporal patterns risk-attributable in 204 countries and territories from 1990 2019 so that prevention control strategies can be prioritized worldwide.We extracted deaths, disability-adjusted life years (DALYs), age-standardized mortality rates (ASMRs), DALY (ASDRs) global disease (GBD) 2019, terms behavioral, metabolic, dietary factors by age, sex, geographical location. Average annual percentage change (AAPC) was used assess long-term trends ASMRs ASDRs due risk factors.Between greatest decrease attributed low intake fruits vegetables. An AAPC -2.96 (95% CI -3.28 -2.63) -3.12 -3.44 -2.79) ASMR ASDR attributable a low-fruit diet, while an -3.60 -3.84 -3.36) -3.64 -3.92 -3.35) low-vegetable diet. However, high BMI showed significant increases 0.52 0.29-0.75) 0.42 0.18-0.66) compared decreases other risks AAPC<0 (P<.05). East Asia had largest diets, -11.00 -11.32 -10.67) -11.81 -12.21 -11.41) ASDR, followed Central Asia, whereas Western Sub-Saharan Africa increase BMI, 3.28 3.14-3.42) 3.09 2.96-3.22), respectively. China highest smoking, alcohol use, diets. Between there chewing tobacco, diets most countries, wherein BMI.Our shows smoking consumption vegetables shown recently. The patterns, future studies should focus on upward trend BMI.

Язык: Английский

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The global incident gastrointestinal cancers attributable to suboptimal diets from 1990 to 2018

Gastroenterology, Год журнала: 2024, Номер 167(6), С. 1141 - 1151

Опубликована: Июль 15, 2024

Язык: Английский

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Short-term outcomes and quality of life of esophagogastrostomy versus the double-tract reconstruction after laparoscopic proximal gastrectomy

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 28, 2024

There is no optimal reconstruction technique after proximal gastrectomy. The esophagogastrostomy (EG) a rather simple procedure technically, but the incidences of reflux esophagitis and anastomotic stricture are higher. While double-tract (DTR) can lessen postoperative esophagitis, it technically complex with long operation time. purpose this study was to evaluate quality life (QoL) short-term outcomes two techniques. We retrospectively collected consecutive patients upper-third gastric adenocarcinoma esophagogastric junction (AEG) at our center between 2019 June 2023 May. Patients who underwent laparoscopic gastrectomy (LPG) EG or DTR were included in study. A comparison made clinical pathological characteristics their surgical parameters, complications, its 1-year QoL groups. groups assessed by Visick grading, European Organization for Research Treatment Cancer (EORTC) QLQ-C30 EORTC QLQ-STO22 scales 1 year operation. nutritional status evaluated BMI, hemoglobin serum albumin. AII qualified divided group (n = 63) 93). Compared group, blood loss volume more (p 0.001). significant differences duration, number lymph nodes dissected, length stay groups(p > 0.05). No statistical observed terms incidence early complications Clavien-Dindo classification as well(p After one year, grade better than 0.040). multivariable logistic regression analysis showed only independent risk factor method. According questionnaire, had global health status(p 0.001) complained less about nausea vomiting(p 0.033), appetite 0.022). 0.030) based on questionnaire. multiple linear revealed that method, age relationship score. Regarding status, BMI both decreased operation, decline value lower statistically difference change Our findings suggest possible skilled surgeons achieve minimal without significantly increasing duration when performing DRT, which does not raise risk. In anti-reflux, maintenance, follow-up reveal superior EG, deserve further research promotion.

Язык: Английский

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LASSO-derived prognostic model predicts cancer-specific survival in advanced pancreatic ductal adenocarcinoma over 50 years of age: a retrospective study of SEER database research

Frontiers in Oncology, Год журнала: 2024, Номер 13

Опубликована: Янв. 14, 2024

Background This study aimed to develop a prognostic model for patients with advanced ductal adenocarcinoma aged ≥50 years. Methods Patient information was extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Least absolute shrinkage selection operator (LASSO) Cox regression analysis performed screen variables. Cases Nanchang Central Hospital were collected external validation. The new nomogram American Joint Committee on Cancer (AJCC) criteria evaluated using integrated discrimination improvement (IDI) net reclassification index (NRI) indicators. Survival curves presented prognosis of classification system AJCC criteria. In total, 17,621 eligible included. Lasso selected 4 variables including age, chemotherapy, radiotherapy stage. C-index training cohort 0.721. value validation 0.729. AUCs cohorts at 1, 2, 3 years 0.749, 0.729, 0.715, respectively. calibration showed that predicted actual probabilities matched. External confirmed model’s outstanding predictive power. Decision curve indicated clinical benefit higher than staging system. evaluation indices preceded NRI (1-year: 0.88, 2-year: 0.94, 3-year: 0.72) IDI 0.24, 0.23, 0.22). Kaplan–Meier implied more capable distinguishing between different risks. Conclusions established risk pancreatic cancer in provide practical tool management adenocarcinoma.

Язык: Английский

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Comparison of the burden of digestive diseases between China and the United States from 1990 to 2019

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Май 17, 2024

Introduction China has experienced unprecedented transformations unseen in a century and is gradually progressing toward an emerging superpower. The epidemiological trends of digestive diseases the United States (the US) have significant prescient effects on China. Methods We extracted data 18 from Global Burden Diseases 2019 Data Resource. Linear regression analysis conducted by JoinPoint software assessed average annual percentage change burden. performed subgroup analyses based sex age group. Results In 2019, there were 836.01 180.91 million new cases US, causing 1558.01 339.54 thousand deaths. age-standardized incidence rates US 58417.87/100,000 55018.65/100,000 respectively, resulting mortality 81.52/100,000 60.88/100,000. annually decreased 2.149% for 2.611% disability-adjusted life year (DALY). DALY had changes −0.219 −0.251. Enteric infections cirrhosis other chronic liver accounted highest prevalence both counties, respectively. burden multiple exhibited notable disparities. middle-old persons higher rates. Conclusion bore greater diseases, evolving patterns more noticeable. Targeted interventions urgent measures should be taken countries to address specific their different epidemic degree.

Язык: Английский

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Trends and cross-country inequality in the incidence of GI cancers among the working-age population from 1990 to 2021: a Global Burden of Disease 2021 analysis

Gut, Год журнала: 2024, Номер unknown, С. gutjnl - 333932

Опубликована: Дек. 31, 2024

GI cancers pose an increasing global health burden, with their impact on the working-age population (WAP) aged 15-64 years remaining largely unexplored despite crucial role of this group in societal and economic well-being.

Язык: Английский

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Short-term outcomes of laparoscopic D2 lymphadenectomy versus D2 lymphadenectomy plus complete mesogastric excision in distal gastric cancer patients with high body mass index

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 23, 2025

The technical challenges and safety issues involving laparoscopic D2 lymphadenectomy plus complete mesogastric excision (D2 + CME) for high body mass index (BMI) patients are still unknown. This study was conducted to compare the short-term outcomes of CME in distal gastric cancer different BMI status. We retrospectively analyzed data with who underwent laparoscopic-assisted gastrectomy (LADG) at our center between 2019 June 2023 September. Patients traditional were divided into group, while undergoing group. In each further subdivided based on their group (H-BMI, ≥ 25) normal (N-BMI, BMI<25) A comparison made characteristics two subgroups, respectively. Propensity score matching (PSM) 1:1 ratio performed assess groups. AII qualified (n = 329) 261). subgroup analysis early surgical had longer surgery time (p 0.007), more blood loss 0.006) first flatus 0.001), compared subgroup. Conversely, significant differences not observed subgroups(p > 0.05). PSM yielded 44 comparable baseline B Compared received shorter time(p<0.001), less loss(p 0.004), retrieved lymph nodes (LNs) 0.016). No statistical terms time, pT stage, pN pathological stage(pStage), vascular invasion, postoperative complications, or hospital stay(p Our findings suggest status a impact results conventional lymphadenectomy. However, unaffected by BMI. addition, benefit from outcomes. Laparoscopic is recommended technique BMI, which deserves promotion.

Язык: Английский

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