Global burden and trends of norovirus-associated diseases from 1990 to 2021 an observational trend study

Frontiers in Public Health, Год журнала: 2025, Номер 12

Опубликована: Янв. 7, 2025

Norovirus remains a significant viral cause of waterborne and foodborne gastroenteritis outbreaks epidemics worldwide. The burden norovirus extends across different income settings. Leveraging secondary data from the 2021 Global Burden Diseases Study, our analysis spanned period 1990 to assess norovirus-associated diseases (NADs). We utilized descriptive statistics examine global mortality rates disability-adjusted life years (DALYs). For trend analysis, we employed annual percentage change (EAPC) through linear regression applied Joinpoint identify changes over time. A comprehensive age-period-cohort model evaluated key risk factors. Furthermore, Bayesian was conducted forecast trends up 2035, providing valuable insights for policy formulation resource allocation. In 2021, age-standardized rate (ASMR) NADs 1.62 per 100,000 population (95% UI: 0.35 2.91), while DALY (ASDR) 79.02 26.61 132.26). downward observed in most regions countries, with EAPC -4.29% -4.53 -4.05) ASMR -4.40% -4.62 -4.19) ASDR 2021. Notably, children under 5 old had considerably higher ASDR: 475.52 160.73 893.72) males 335.44 112.29 623.48) females. Mortality escalated age, peak 69.27 CI: 64.04 74.92) under-five age group, 11.38 10.59 12.22) individuals 95 years. Age-Period Cohort projections indicate continued decline 2035. Between significantly declined due public health interventions, vaccination, improved sanitation. However, highly contagious, especially among older adult. Projections suggest decrease such by To further reduce this burden, preventive measures like vaccination infection control strategies are essential high-risk populations, alongside ongoing research into epidemiology transmission dynamics.

Язык: Английский

---

Global temporal trends and projections of hepatitis B-related cirrhosis among adolescents and young adults from 1990 to 2035: an analysis based on the global burden of disease study 2021

Frontiers in Public Health, Год журнала: 2025, Номер 12

Опубликована: Янв. 8, 2025

Chronic hepatitis B and cirrhosis pose significant global health threats. Few studies have explored the disease burden mortality trend of caused by virus infection among adolescents young adults (AYAs, aged 15-39 years). This study aimed to assess trends. Publicly available data were obtained from 2021 GBD database. The rates incidence, mortality, disability-adjusted life years calculated at global, regional, national levels. Temporal trends assessed using joinpoint regression analysis, while Bayesian age-period-cohort model was used predict future From 1990 2021, incidence rate B-related decreased 111.33 (95% uncertainty interval: 89.18 134.98) 67.75 (54.06 82.71) per 100,000 with an average annual percentage change -1.58 confidence -1.66 -1.51, p < 0.001). However, between numbers in 30-34 35-39 age groups increased 23.75 21.24%, respectively. number deaths low low-middle Socio-demographic Index (SDI) areas 79.51 20.62%, Moreover, it is predicted that incidences will continue rise SDI. At regional level, Central Sub-Saharan Africa had highest rates. In Somalia Democratic Republic Congo rates, whereas Kiribati Cambodia overall AYAs has over past three decades. Nevertheless, there a slight increase individuals 30-39 years. substantial SDI underscore need for sustained targeted public interventions.

Язык: Английский

---

Therapeutic Potential of Vanillic Acid in Ulcerative Colitis Through Microbiota and Macrophage Modulation

Molecular Nutrition & Food Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

This study investigated the protective effects of dietary polyphenol vanillic acid (VA) on dextran sulfate sodium-induced acute ulcerative colitis (UC) in mice, focusing its impact gut microbiota and inflammatory responses. VA was supplemented following sodium administration, key indicators, including body weight, disease activity index, colon length, spleen markers, were assessed. supplementation significantly alleviated UC symptoms, preserved intestinal barrier integrity, reduced pro-inflammatory cytokine levels. Additionally, positively altered composition, promoting beneficial bacteria such as Akkermansia muciniphila while suppressing arachidonic metabolism pathway. Fecal transplantation confirmed that VA-modified contributed to these effects. also facilitated macrophage polarization from M1 phenotype anti-inflammatory M2 phenotype, further mitigating inflammation. These findings highlight potential a natural intervention for UC, emphasizing role regulating pathways, which may have significant nutritional relevance managing bowel diseases.

Язык: Английский

---

Psoriasis Burden: Global Burden of Disease Study 2021

Опубликована: Янв. 1, 2025

---

Dissecting the rising tide of inflammatory bowel disease among youth in a changing world: insights from GBD 2021

International Journal of Colorectal Disease, Год журнала: 2025, Номер 40(1)

Опубликована: Фев. 18, 2025

This study investigates the alarming epidemiological trends of inflammatory bowel disease (IBD) among children and young adults, highlighting associated burden on global health. Utilizing data from Global Burden Disease (GBD) 2021, we conducted a comprehensive analysis age-standardized incidence rates (ASIR), mortality (ASMR), disability-adjusted life years (DALYs), estimated annual percentage changes (EAPC). Future were forecasted using Bayesian age-period-cohort model. From 1990 to IBD DALY remained persistently high, with concerning upward trend noted adults. While men experienced decline in rates, women faced increasing burdens. In high-income regions, particularly North America, reported highest contrasting sharply Central Latin which exhibited lowest ASIR. Southeast Asia presented most favorable rates. A notable negative correlation was identified between socio-demographic index (SDI) at national level, high high-middle SDI countries continuing bear substantial burden, while low middle nations rising challenges. The persistent adults signifies critical public health concern. marked geographical gender disparities underscore urgent need for tailored regional population-based strategies aimed primary prevention effective management. illuminates pressing necessity policy interventions address growing epidemic vulnerable populations.

Язык: Английский

---