Obstetric Outcomes during COVID-19 Pandemic: Vaccination and Infection in Pregnancy DOI Creative Commons
Merve Dizdar, Ayşegül Çakmak, Işıl Ada Uçar

и другие.

Clinical and Experimental Obstetrics & Gynecology, Год журнала: 2024, Номер 51(1), С. 13 - 13

Опубликована: Янв. 9, 2024

Background: Coronavirus disease 2019 (COVID-19) infection is associated with increased perinatal morbidity and mortality. Despite this, vaccination hesitancy among pregnant women remains to be a huge problem. In this study we aimed evaluate COVID-19 safety uptake in pregnancy, adverse outcomes compared non-infected women. Methods: This retrospective single-institution cohort of who gave birth 2021. The primary the were during comparison infected pregnancy group vs non-infected. secondary included vaccine rate, trimester evaluation safety, side effects. Results: Among 3620 deliveries, 1943 individuals eligible before delivery analysis. Out women, 212 (10.9%) received at least one dose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pregnancy. 189 (89.2%) them BNT162b2 (Pfizer/BioNTech) 23 (10.8%) CoronaVac (Sinovac). Following propensity score matching, no significant increase emergency cesarean section (C-section) rates, intrapartum complications, stillbirth, congenital anomalies, maternal or neonatal intensive care unit (NICU) admissions found vaccinated non-vaccinated (p > 0.05, for all). 436 history polymerase chain reaction (PCR) positivity 2972 tested negative. No overall effects identified due Perinatal similar both groups subgroup analysis NICU admission was lowest third < 0.001). Antenatal higher pregestational diabetes, hypothyroidism autoimmune diseases rate (23%, 14%, 20.8% 10.9% respectively). Conclusions: study, not outcomes. Overall, Our results should confirmed bigger order draw more definite conclusions.

Язык: Английский

Vaccine delivery systems and administration routes: Advanced biotechnological techniques to improve the immunization efficacy DOI Creative Commons
Abdellatif Bouazzaoui, Ahmed A. H. Abdellatif

Vaccine X, Год журнала: 2024, Номер 19, С. 100500 - 100500

Опубликована: Май 24, 2024

Since the first use of vaccine tell last COVID-19 pandemic caused by spread SARS-CoV-2 worldwide, advanced biotechnological techniques has accelerated development different types and methods for immunization. The showed that nucleic acid-based vaccine, especially mRNA, an advantage in terms time; however, it a very critical drawback namely, higher costs when compared to other strategies, its inability protect against new variants. This need more improvement reach better delivery efficacy. In this review we will describe systems including, most used viral vector, also variable strategies delivering vaccines lipid-based nanoparticles formulation, polymersomes, electroporation powerful tools which is based on cell-penetrating peptides (CPPs). Additionally, discuss main challenges associated with each system. Finlay, efficacy safety depends not only formulations systems, but dosage route administration are important players, therefore see routes including traditionally (intramuscular, Transdermal, subcutaneous), oral inhalation or via nasal mucosa, advantages disadvantage route.

Язык: Английский

Процитировано

6
Sociodemographic Factors Associated With Established and Novel Antenatal Vaccination Uptake in a Cohort of Pregnant Women in Uganda DOI
Sarah Sturrock, Hannah G Davies, Gordon Rukundo

и другие.

The Pediatric Infectious Disease Journal, Год журнала: 2025, Номер 44(2S), С. S92 - S96

Опубликована: Фев. 1, 2025

Introduction: Vaccination is a key strategy to safeguard the health of pregnant women and newborns. Although vaccine acceptance often higher in low- middle-income countries, COVID-19 pandemic has highlighted increasing hesitancy. Vaccine hesitancy, specifically women, must be understood increase uptake. We used data from Ugandan pregnancy registry study examine sociodemographic factors linked uptake vaccines (tetanus toxoid later COVID-19) pregnancy. Methods: Pregnant were recruited Kampala, Uganda, as part PREPARE (Prevention invasive Group B Streptococcus disease young infants: pathway for evaluation & licensure an investigational maternal GBS vaccine) September 1, 2020 until February 24, 2022. Demographic, socioeconomic obstetric collected alongside tetanus vaccination. Results: One thousand five hundred sixty-eight participants included: 151 (10%) unvaccinated, 11 (1%) received only, 1230 (78%) only 176 (11%) both. Lower vaccination rates seen attending fewer than 4 antenatal care episodes ( P < 0.001), those with parity = 0.036). Higher managerial or professional occupation education level, but paternal was not significantly associated Parish varied 0% 100%, 49 (29%) parishes showing rate <90%. Conclusions: This highlights route promotion, stark difference between new established vaccines. Further qualitative studies should investigate effective interventions establish safety benefit newer across all demographic groups.

Язык: Английский

Процитировано

0
Knowledge, Attitude, Acceptance, and Perceived Risks of COVID-19 Vaccines among Pregnant Women: Findings and Implications DOI Open Access
Steward Mudenda,

Gastone Tembo,

Ruth Lindizyani Mfune

и другие.

SAS Journal of Medicine, Год журнала: 2024, Номер 10(01), С. 9 - 19

Опубликована: Янв. 2, 2024

Introduction: COVID-19 vaccines are essential in reducing symptoms and severity of the disease as well preventing infection with COVID-19. Vaccination pregnant women against has been recommended globally. In Zambia, there is a paucity information on knowledge, attitude, acceptance, perceived risks among women. Therefore, this study assessed vaccination attending antenatal care at Women Newborn Hospital (WNH) University Teaching Hospitals (UTHs) Lusaka, Zambia. Methods: This was descriptive cross-sectional conducted from August 2023 to October 300 Data were collected using structured questionnaire analysed Statistical Package for Social Science (SPSS) version 23.0. The Chi-square test used relationship between dependent independent variables. statistical significance 95% confidence level. Results: Of participants, 186 (62.0%) aged 24 34 years 185 (61.5%) aware that vaccine pregnancy. Overall, 284 (94.7%) had good 258 (86.0%) positive vaccinated. Additionally, 20 (17.5%) who not vaccinated willing be Furthermore, most participants felt safe use results show lower acceptance compared knowledge attitude levels. Having associated education status (X^2=33.011, p=0.001 level) (X^2=9.132, p=0.029 level). Conclusion: found WNH attitudes, perceptions, high ..........

Язык: Английский

Процитировано

2
Factors Affecting COVID-19 Vaccine Acceptance among Pregnant Women: A Cross Sectional Study from Abha City, Saudi Arabia DOI Creative Commons

Asma Saad Habbash,

Aesha Farheen Siddiqui

Vaccines, Год журнала: 2023, Номер 11(9), С. 1463 - 1463

Опубликована: Сен. 7, 2023

Background: Pregnant women can get infected with COVID-19 serious sequelae to them and their fetus. Concerns about vaccination safety mothers babies, doubts its effectiveness, have hindered vaccine acceptance throughout the crisis. The objective of current investigation was estimate rates among pregnant in Abha city, Aseer region, Saudi Arabia, determine clinical demographic correlates. Method: Descriptive questionnaire-based cross-sectional survey a sample attending regular antenatal care services Abha. We used backward stepwise multiple logistic regression analysis evaluate predictability terms baseline factors. Results: included 572 women. prevalence high (93.7%; 95%CI: 91.7-95.7%). University graduates later gestational age were more likely accept (OR = 6.120, p 0.009), (t 2.163, 0.036), respectively. Confidence associated better 3.431, 0.001). Conclusions: rate for Abha, is higher compared international rate. However, our results indicate that confidence acceptance. Hence, overarching predictor harboring positive attitudes towards it. Public health policies should capitalize on such aim total coverage including booster dosages.

Язык: Английский

Процитировано

2
Obstetric Outcomes during COVID-19 Pandemic: Vaccination and Infection in Pregnancy DOI Creative Commons
Merve Dizdar, Ayşegül Çakmak, Işıl Ada Uçar

и другие.

Clinical and Experimental Obstetrics & Gynecology, Год журнала: 2024, Номер 51(1), С. 13 - 13

Опубликована: Янв. 9, 2024

Background: Coronavirus disease 2019 (COVID-19) infection is associated with increased perinatal morbidity and mortality. Despite this, vaccination hesitancy among pregnant women remains to be a huge problem. In this study we aimed evaluate COVID-19 safety uptake in pregnancy, adverse outcomes compared non-infected women. Methods: This retrospective single-institution cohort of who gave birth 2021. The primary the were during comparison infected pregnancy group vs non-infected. secondary included vaccine rate, trimester evaluation safety, side effects. Results: Among 3620 deliveries, 1943 individuals eligible before delivery analysis. Out women, 212 (10.9%) received at least one dose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pregnancy. 189 (89.2%) them BNT162b2 (Pfizer/BioNTech) 23 (10.8%) CoronaVac (Sinovac). Following propensity score matching, no significant increase emergency cesarean section (C-section) rates, intrapartum complications, stillbirth, congenital anomalies, maternal or neonatal intensive care unit (NICU) admissions found vaccinated non-vaccinated (p > 0.05, for all). 436 history polymerase chain reaction (PCR) positivity 2972 tested negative. No overall effects identified due Perinatal similar both groups subgroup analysis NICU admission was lowest third < 0.001). Antenatal higher pregestational diabetes, hypothyroidism autoimmune diseases rate (23%, 14%, 20.8% 10.9% respectively). Conclusions: study, not outcomes. Overall, Our results should confirmed bigger order draw more definite conclusions.

Язык: Английский

Процитировано

0