Incidence and factors associated with SARS-CoV-2 infection and re-infection among people experiencing homelessness in Toronto, Canada: A prospective cohort study DOI Creative Commons
Lucie Richard,

Brooke Carter,

Michael Liu

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0319296 - e0319296

Опубликована: Фев. 28, 2025

People experiencing homelessness are at elevated risk of SARS-CoV-2 infection, yet estimates generally exclude re-infections and rely on data sources affected by testing policies or study timing. In this prospective cohort study, we report incidence infection over time using a combination community-based study-administered testing, assessed individual housing-related factors associated with new infection. Individuals were randomly selected from 62 sites across Toronto, Canada, between June September 2021. Participants provided detailed surveys biological samples to test for (by RT-PCR ELISA) every three months one year. Self-reported verified augmented through linkage health administrative databases. Among 640 participants who completed 2,401 interviews, identified 613 events, representing an rate 35.3 infections/100-person years (95% CI 31.6-39.4) prior the onset Omicron 97.2 infections/100 person-years 86.8-108.8) after Omicron. Nearly 30% (n = 182) these events re-infections. multivariable models, post-Omicron interviews (adjusted ratio [aRR] 3.54 [95% 3.12-4.02]), history COVID-19 (1 aRR 2.55 2.29-2.83]; 2 + infections 2.28 1.80-2.89]) residing in high- moderate-exposure (congregate shared) housing settings (high-exposure 1.74 1.43-2.11]; 1.39 [1.15-1.68]) most significantly Our findings highlight that existing reports underestimate burden among people homelessness, but confirms previously reported including congregate shared settings. Reducing reliance overcrowded emergency is necessary reduce population as well inequities downstream acute chronic complications.

Язык: Английский

Incidence and factors associated with SARS-CoV-2 infection and re-infection among people experiencing homelessness in Toronto, Canada: A prospective cohort study DOI Creative Commons
Lucie Richard,

Brooke Carter,

Michael Liu

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0319296 - e0319296

Опубликована: Фев. 28, 2025

People experiencing homelessness are at elevated risk of SARS-CoV-2 infection, yet estimates generally exclude re-infections and rely on data sources affected by testing policies or study timing. In this prospective cohort study, we report incidence infection over time using a combination community-based study-administered testing, assessed individual housing-related factors associated with new infection. Individuals were randomly selected from 62 sites across Toronto, Canada, between June September 2021. Participants provided detailed surveys biological samples to test for (by RT-PCR ELISA) every three months one year. Self-reported verified augmented through linkage health administrative databases. Among 640 participants who completed 2,401 interviews, identified 613 events, representing an rate 35.3 infections/100-person years (95% CI 31.6-39.4) prior the onset Omicron 97.2 infections/100 person-years 86.8-108.8) after Omicron. Nearly 30% (n = 182) these events re-infections. multivariable models, post-Omicron interviews (adjusted ratio [aRR] 3.54 [95% 3.12-4.02]), history COVID-19 (1 aRR 2.55 2.29-2.83]; 2 + infections 2.28 1.80-2.89]) residing in high- moderate-exposure (congregate shared) housing settings (high-exposure 1.74 1.43-2.11]; 1.39 [1.15-1.68]) most significantly Our findings highlight that existing reports underestimate burden among people homelessness, but confirms previously reported including congregate shared settings. Reducing reliance overcrowded emergency is necessary reduce population as well inequities downstream acute chronic complications.

Язык: Английский

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