The nature of self-medication in Uganda: a systematic review and meta-analysis
BMC Public Health,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 17, 2025
In
Uganda,
many
people
self-medicate
and
the
practice
raises
important
questions
about
access
to
healthcare,
patient
choices,
increasing
prevalence
of
antimicrobial
resistance.
This
systematic
review
meta-analysis
investigated
factors
associated
with
self-medication
in
Uganda.
We
searched
Scopus,
PubMed,
Embase
databases,
WHO
AFRO,
UNIPH
registries,
Google
Scholar
search
engine
from
inception
November
2024
using
algorithm
"Self-Medication"
AND
"Uganda".
Twenty-two
eligible
studies
were
included
while
adhering
preferred
reporting
items
for
reviews
(PRISMA).
A
total
9113
participants
represented
across
different
demographics
regions
Our
analysis
revealed
a
55.63%
(95%CI
[40.40;
70.66]
pooled
Antibiotics
are
commonly
self-medicated
drugs
ease
medications,
perceived
cost
effectiveness,
long
hospital
waiting
time,
home
storage
(leftovers),
perceptions
minor
illnesses
key
contributors
behaviour.
At
least
1
2
Ugandans
antibiotics
constitute
dominant
compounding
situation
an
era
Awareness
campaigns
on
dangers
will
be
timely.
Язык: Английский
Assessment of health conditions from patient electronic health record portals vs self-reported questionnaires: an analysis of the INSPIRE study
Journal of the American Medical Informatics Association,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Direct
electronic
access
to
multiple
health
record
(EHR)
systems
through
patient
portals
offers
a
novel
avenue
for
decentralized
research.
Given
the
critical
value
of
characterization,
we
sought
compare
computable
evaluation
conditions
from
patient-portal
EHR
against
traditional
self-report.
In
nationwide
Innovative
Support
Patients
with
SARS-CoV-2
Infections
Registry
(INSPIRE)
study,
which
linked
self-reported
questionnaires
multiplatform
data,
compared
across
different
clinical
domains
definitions
based
on
diagnosis
codes,
medications,
vital
signs,
and
laboratory
testing.
We
assessed
their
concordance
using
Cohen's
Kappa
prognostic
significance
differentially
captured
features
as
predictors
1-year
all-cause
hospitalization
risk.
Among
1683
participants
(mean
age
41
±
15
years,
67%
female,
63%
non-Hispanic
Whites),
prevalence
varied
substantially
between
self-report
(-13.2%
+11.6%
definitions).
Compared
comprehensive
phenotypes,
under-captured
all
conditions,
including
hypertension
(27.9%
vs
16.2%),
diabetes
(10.1%
6.2%),
heart
disease
(8.5%
4.3%).
However,
codes
alone
were
insufficient.
The
risk
was
better
defined
by
same
(area
under
receiver
operating
curve
[AUROC]
0.79)
than
(AUROC
0.68).
EHR-derived
phenotypes
identified
higher
comorbidities
self-report,
additionally
features.
solely
often
undercaptured
suggesting
role
broader
elements.
this
patient-portal-derived
data
enabled
extensive
capture
characteristics
platforms,
allowing
phenotyping
Язык: Английский
Role of Gut Microbiota in Long COVID: Impact on Immune Function and Organ System Health
Archives of Microbiology & Immunology,
Год журнала:
2025,
Номер
9(1)
Опубликована: Янв. 1, 2025
SARS-CoV-2
infection
has
led
to
a
range
of
long-lasting
symptoms,
collectively
referred
as
long
COVID.
Current
research
highlights
the
critical
role
angiotensin-converting
enzyme
2
(ACE2)
in
regulating
gut
microbiota
diversity,
vascular
function,
and
homeostasis
within
renin-angiotensin
system
(RAS).
ACE2
is
utilized
by
virus
enter
host
cells,
but
its
downregulation
following
contributes
dysbiosis
RAS
disruption.
These
imbalances
have
been
linked
COVID
including
joint
pain,
chest
chronic
cough,
fatigue,
brain
fog,
anxiety,
depression,
myalgia,
peripheral
neuropathy,
memory
difficulties,
impaired
attention.
This
review
investigates
dysregulation
caused
long-term
effects
it
on
various
organ
systems,
musculoskeletal,
neurological,
renal,
respiratory,
cardiovascular
systems.
We
explored
bidirectional
interactions
between
microbiota,
immune
these
focusing
how
inflammation
dysfunction
observed
symptoms.
Understanding
key
for
identifying
effective
therapeutic
strategies
interventional
targets
aimed
at
mitigating
impact
health
improving
patient
outcomes.
Язык: Английский
Engaging health system, service and consumer representatives in the co-design of a multi-criteria decision-making framework for commissioning overweight and obesity programs and services
Health Research Policy and Systems,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 20, 2025
Obesity
is
a
multi-faceted
problem
that
requires
complex
health
system
responses.
While
no
single
program
or
service
sufficient
to
meet
every
individual's
needs,
some
criteria
increase
the
likelihood
of
program/service
quality
delivery
produce
effective
outcomes
exist.
However,
although
research
on
commissioning
available
internationally
and
growing
within
Australian
context,
evidence
exists
multi-criteria
decision-making
framework
address
complexity
required
for
overweight
obesity
early
intervention
weight
management
programs
services.
This
study
aimed
develop
set
support
in
this
context.
A
mixed-methods
co-design
approach
was
used
framework.
literature
review
informed
three-stage
consensus-gathering
approach.
Participants
included
Western
stakeholders
from
system,
services
consumers,
who
reviewed,
ranked
validated
responses
through
ongoing
discussions.
deliberative
forum
held
between
two
online,
modified
Delphi
surveys
reach
consensus
among
stakeholders.
Through
co-design,
total
63
were
identified:
24
completed
round
1
survey
assessing
22
proposed
criteria,
40
attended
30
2
survey.
4
themes
arose
process:
(1)
reduce
duplication,
(2)
demote
(3)
re-organize
(4)
simplify
language,
10
established:
safety,
collaboration
consultation,
appropriateness,
effectiveness,
efficiency,
equity,
evidence-based,
model,
sustainability
workforce
capacity
competence.
The
underpinned
by
indicators
highlighting
relevant
sub-themes.
developed
its
application
process
will
enable
selection
likely
have
an
impact
individuals'
use
satisfaction
with
services,
obesity-related
inter-agency
collaborations
maximize
economic
resources.
Язык: Английский
RETRACTED ARTICLE: Changes in Blood Pressure is Associated with Bone Loss in US Adults: A Cross-Sectional Study from NHANES 2005–2018
Calcified Tissue International,
Год журнала:
2024,
Номер
114(3), С. 276 - 285
Опубликована: Янв. 23, 2024
Язык: Английский
Pandemic Impact on Research Faculty in Academic Medicine: A Mixed Method Study
Women s Health Reports,
Год журнала:
2025,
Номер
6(1), С. 21 - 28
Опубликована: Янв. 1, 2025
This
mixed-method
study
sought
to
elucidate
the
impact
of
COVID-19
on
professional
environments
and
career
trajectories
midcareer
research
faculty
in
U.S.
medical
schools.
Participants
were
40
school
enrolled
Brandeis
University
C-Change
Mentoring
Leadership
Institute,
a
group
peer
mentoring
development
course
being
tested
National
Institutes
Health-funded
randomized
controlled
trial.
We
observed
gender
disparity
both
quantitative
qualitative
data,
with
women
describing
more
negatively
impacting
their
trajectory.
negative
was
independent
having
children
home.
largely
reported
no
change
commitment
conducting
or
interest
applying
for
funding.
A
total
54%
effect
pandemic
relationships
colleagues
(n
=
21)
33%
13).
trend
emerged
when
examining
data
by
degree,
however,
PhD
about
twice
as
likely
physicians
report
relationship
(47%
n
9
vs.
20%
4,
respectively).
The
ordinal
test
5-point
scale
approached
statistical
significance
but
did
not
meet
standard
0.05
cut-off
(p
value
0.06;
Z-value
-1.86).
While
initially
some
positive
outcomes
SARS-CoV-2
own
experiences
April
2020,
1
year
later
reflected
impacts
trajectory,
especially
women,
colleagues,
higher
intensity
signal
scientists.
Язык: Английский
Race, Ethnicity, and Gender Differences in Patient Reported Well-Being and Cognitive Functioning Within 3 Months of Symptomatic Illness During COVID-19 Pandemic
Journal of Racial and Ethnic Health Disparities,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 22, 2024
Differences
in
acute
COVID-19
associated
morbidity
based
on
race,
ethnicity,
and
gender
have
been
well
described;
however,
less
is
known
about
differences
subsequent
longer
term
health-related
quality
of
life
well-being.
Язык: Английский