Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 21, 2025
Rapid
vaccine
development
and
innovative
immunotherapeutics
are
critical
in
the
fight
against
emerging
outbreaks
global
pandemic
threats,
yet
high
costs
prolonged
timelines
for
developing
new
vaccines
underscore
urgent
need
robust,
predictive
pre-clinical
testing
platforms.
The
rapid
down-selection
of
candidates
identification
optimal
formulations
can
be
performed
using
human
vitro
immunization
(IVI)
assays
that
recapitulate
complex
interactions
innate
adaptive
immune
response.
In
this
review,
we
present
a
comprehensive
evaluation
three
key
IVI
platforms:
whole
blood
assay
(WBA),
monocyte-derived
dendritic
cell
(MoDC)
with
cell-T
interface
(DTI),
microphysiological
tissue
construct
(HTC).
WBA
offers
cost-effective
straightforward
approach,
while
MoDC
+
DTI
system
represents
current
gold
standard
balancing
experimental
efficiency
immunological
complexity.
HTC
assay,
by
mimicking
both
spatial
temporal
aspects
interactions,
provides
enhanced
physiological
relevance.
We
discuss
methodological
advantages
limitations
each
platform,
explore
their
roles
candidate
screening,
propose
strategies
integrating
these
complementary
vivo
models.
These
insights
pave
way
refining
accelerating
translational
pipeline
next-generation
immunotherapies.
Vaccines,
Год журнала:
2024,
Номер
12(8), С. 891 - 891
Опубликована: Авг. 7, 2024
The
COVID-19
pandemic
has
underscored
the
critical
importance
of
adaptable
and
resilient
public
health
systems
capable
rapid
response
to
emerging
crises.
This
paper
synthesizes
lessons
learned
from
vaccination
campaign
explores
strategies
enhance
vaccine
uptake
in
post-pandemic
era.
Key
challenges
identified
include
logistical,
economic,
sociocultural,
policy
dimensions
that
impact
efforts,
particularly
low-resource
settings.
analysis
highlights
need
for
supply
chains,
effective
communication,
community
engagement,
equitable
access
healthcare
resources.
development
deployment
mRNA
vaccines
exemplify
potential
innovative
technologies,
though
trust
acceptance
remain
crucial.
Strategies
such
as
partnerships
with
local
leaders,
tailored
messaging,
integration
digital
tools
are
essential
combating
hesitancy.
By
applying
these
insights,
future
campaigns
can
be
more
efficient,
equitable,
resilient,
ultimately
improving
outcomes
globally.
aims
inform
practice,
ensuring
evidence
based
context
specific,
thus
better
preparing
challenges.
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1201 - 1201
Опубликована: Сен. 13, 2024
Chitosan
is
the
most
commonly
investigated
functional
cationic
biopolymer
in
a
wide
range
of
medical
applications
due
to
its
promising
properties
such
as
biocompatibility,
biodegradability,
and
bioadhesivity,
well
numerous
bioactive
properties.
Within
last
three
decades,
chitosan
derivatives
have
been
biomaterials
for
drug
vaccine
delivery
systems,
besides
their
Due
groups
structure,
it
possible
tailor
systems
with
desired
There
has
great
interest
application
chitosan-based
also
prevention
treatment
infectious
diseases,
specifically
antimicrobial,
antiviral,
immunostimulatory
effects.
In
this
review,
recent
diseases
are
reviewed,
possibilities
limitations
regards
technical
regulatory
aspects
discussed.
Finally,
future
perspectives
on
utilization
biomaterial
Discourse & Communication,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
The
digital
infrastructure
of
anti-vaccination
tweets
circulates
and
amplifies
vaccine
hesitancy,
leading
to
declined
vaccination
rates,
amplified
susceptibility
preventable
diseases,
an
endangered
public
health
landscape.
article
carefully
looks
at
a
collection
from
different
sources,
such
as
individuals,
political
leaders,
agencies,
find
out
how
arguments
for
against
vaccinations
are
discussed,
people
interact
with
each
other,
what
makes
Twitter
users
in
the
USA
India
different.
We
applied
Mann–Whitney
U
test
understand
engagement
patterns
pro-
tweets,
used
critical
discourse
analysis
method
on
corpus
reveal
four
discursive
strategies
vaccination:
(a)
management,
(b)
government
emergency
preparedness,
(c)
concerns
criticisms,
(d)
emotional
spectrum
surrounding
vaccination.
findings
show
that
is
higher
proponents
vaccines
both
countries.
However,
motivation
factors
boycotts
differ
substantially
those
USA.
These
results
underscore
imperative
healthcare
entities,
governments,
policymakers
develop
population-specific
strategies,
considering
their
geographical
cultural
backgrounds,
address
epidemics
vaccines.
Abstract
Background
Despite
data
supporting
the
safety
of
SARS‐CoV‐2
vaccination,
concerns
regarding
receipt
blood
products
from
donors
previously
infected
or
vaccinated
against
persist.
We
assessed
whether
transfusions
plasma
platelet
with
prior
infection
vaccination
were
associated
adverse
outcomes
in
patients
without
COVID‐19.
Methods
linked
donor
spike
and
nucleocapsid
antibody
history
to
transfused
between
June
1,
2020
March
31,
2022.
used
logistic
regression,
adjusting
for
demographics
comorbidities,
calculate
odds
ratios
95%
confidence
intervals
(CI)
posttransfusion
thrombosis,
increased
respiratory
requirement,
hospital
mortality.
Outcomes
as
per
unit
compared
units
uninfected
unvaccinated
donors.
Results
Among
8715
hospitalizations
7773
transfusion
recipients
data,
there
251
thromboses,
700
requirements,
1443
deaths.
15,167
units,
4993
1106
donors,
respectively.
19,295
8530
1368
There
no
associations
mortality
(all
CI
including
1).
Nor
recently
high
titers
outcomes.
Discussion
Donor
SARS‐Cov‐2
not
patient
do
need
be
considered
allocation.
Vaccines,
Год журнала:
2024,
Номер
12(5), С. 533 - 533
Опубликована: Май 13, 2024
Merkel
cell
carcinoma
is
a
rare,
aggressive
skin
cancer
that
mainly
occurs
in
elderly
and
immunocompromised
patients.
Due
to
the
success
of
immune
checkpoint
inhibition
MCC,
importance
immunotherapy
vaccines
MCC
has
increased
recent
years.
In
this
article,
we
aim
present
current
progress
perspectives
development
for
disease.
Here,
summarize
discuss
literature
ongoing
clinical
trials
investigating
against
MCC.
We
identified
10
articles
through
PubMed
search
vaccine
From
international
trial
database
Clinical.Trials.gov,
nine
studies
on
management
which
seven
are
actively
recruiting.
Most
preclinical
or
phase
1/2
trials.
The
principles
included
DNA-
(synthetic)
peptide-based
vaccines,
but
RNA-based
oncolytic
viruses,
combination
also
under
investigation
treatment
Although
changing,
when
compared
times
before
approval
inhibitors,
it
will
still
take
some
time
first
ready
approval.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(22), С. 25287 - 25313
Опубликована: Ноя. 12, 2024
The
emergence
of
antibiotic-resistant
biofilms
poses
a
significant
challenge
in
healthcare,
as
these
complex
microbial
communities
demonstrate
an
increased
resistance
to
conventional
treatment
methods.
Traditional
antibiotics
often
fail
against
biofilms,
resulting
persistent
infections
and
failures.
To
address
this
urgent
issue,
innovative
strategies
such
bioinspired
nanomaterials,
antimicrobial
peptides,
quorum
sensing
inhibitors,
combination
therapies
show
promise
disrupting
biofilm
structures,
enhancing
activity,
overcoming
mechanisms.
Bioinspired
nanomaterials
have
emerged
pivotal
approach
for
tackling
the
challenges
presented
by
pathogens
across
various
sectors,
including
industry,
environmental
protection.
Their
advantages
include
enhanced
biocompatibility,
targeted
delivery,
improved
efficacy
formation
threats.
Recent
advancements
highlight
potential
solutions,
nanoparticles,
smart
nanocarriers,
surface
modifications,
nanozymes,
combating
biofilm-related
issues.
Despite
progress
nanomaterial
research,
remain.
intricate
interactions
within
evolving
nature
necessitate
multidisciplinary
approaches.
Furthermore,
translating
laboratory
findings
into
practical
applications
faces
obstacles
related
scalability,
stability,
regulatory
compliance.
Future
are
expected
focus
on
multifunctional
nanoparticles
that
disrupt
advanced
modifications
better
interaction,
nanocarriers
nanozymes
dismantle
structures.
This
review
focuses
development
application
pathogen
challenges.
It
emphasizes
roles
targeting
capabilities.
Additionally,
explores
formulating
management
practices,
providing
insights
advantages,
limitations,
future
perspectives
Vaccines,
Год журнала:
2025,
Номер
13(1), С. 78 - 78
Опубликована: Янв. 16, 2025
Recoding
strategies
have
emerged
as
a
promising
approach
for
developing
safer
and
more
effective
vaccines
by
altering
the
genetic
structure
of
microorganisms,
such
viruses,
without
changing
their
proteins.
This
method
enhances
vaccine
safety
efficacy
while
minimizing
risk
reversion
to
virulence.
frequency
CpG
dinucleotides,
which
in
turn
activates
immune
responses
ensures
strong
attenuation
pathogens.
Recent
advancements
highlight
synonymous
recoding's
potential,
offering
improved
stability
immunogenicity
compared
traditional
methods.
Live
attenuated
using
classical
methods
pose
virulence
can
be
time-consuming
produce.
Synonymous
recoding,
involving
numerous
codon
alterations,
boosts
stability.
One
challenge
is
balancing
with
yield;
however,
innovations
like
Zinc-finger
antiviral
protein
(ZAP)
knockout
cell
lines
enhance
production.
Beyond
viral
vaccines,
recoding
apply
bacterial
exemplified
modified
Escherichia
coli
Streptococcus
pneumoniae
strains,
show
reduced
Despite
results,
challenges
ensuring
stability,
high
yield,
regulatory
approval
remain.
Briefly,
ongoing
research
aims
harness
these
comprehensive
improvements
design
deployment.
In
this
commentary,
we
sought
further
engage
community's
interest
elegant
briefly
highlighting
its
main
advantages,
disadvantages,
future
prospects.
