Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Апрель 26, 2025
Язык: Английский
Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Апрель 26, 2025
Язык: Английский
Medicina, Год журнала: 2024, Номер 60(10), С. 1647 - 1647
Опубликована: Окт. 8, 2024
The most prevalent reason for vision impairment in aging inhabitants is age-related macular degeneration (AMD), a posterior ocular disease with poor understanding of the anatomic, genetic, and pathophysiological progression disease. Recently, new insights exploring role atrophic changes retinal pigment epithelium, extracellular drusen deposits, lysosomal lipofuscin, various genes have been investigated AMD. Hence, this review explores incidence risk factors AMD, such as oxidative stress, inflammation, complement system, involvement bioactive lipids their angiogenesis. In addition to intravitreal anti-vascular endothelial growth factor (VEGF) therapy other therapeutic interventions oral kinase inhibitors, photodynamic, gene, antioxidant therapy, well benefits drawbacks AMD treatment options, strategic drug delivery methods, including routes focus on pharmacokinetics, are investigated. Further, recent advancements nanoformulations polymeric lipid nanocarriers, liposomes, etc., intended pros cons too summarized. Therefore, purpose give researchers an pathophysiology, emphasis angiogenesis, function lipids, options. Additionally, options that development system(s) via several can aid advancement choices.
Язык: Английский
Процитировано
5Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 285, С. 117068 - 117068
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
3Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Апрель 26, 2025
Язык: Английский
Процитировано
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