Trend Analysis of Global, Regional, and National Burdens of Visual Impairment Due to Refraction Disorders from 1990 to 2021: Findings from the Global Burden of Disease Study 2021 DOI
Qing Zhou,

Ting Tang,

Yongbing Cai

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Abstract Purpose To estimate the global, regional, and national burden of vision impairment due to refraction disorders (RD) from 1990 2021 based on sex, age, Socio-demographic Index (SDI), predict future disease trends.Methods This retrospective demographic analysis utilized data Global Burden Disease (GBD) database. Prevalence, years lived with disability (YLDs), age-standardized prevalence rates (ASPR), YLDs (ASYR) RD were analyzed assess temporal, sex-specific trends. We calculated Average Annual Percentage Change (AAPC) determine changes in used Bayesian Age-Period-Cohort (BAPC) model forecast 2020 2035.Results ASPR ASYR declined 2021, AAPC is -3.76 (95% confidence interval [CI]: -4.20~-3.32) − 0.26 CI: -0.28~-0.25), respectively. In global was 159,765,917 uncertainty [UI]: 142,526,915 ~ 178,698,348). The slightly higher females than males, a among middle-aged elderly populations. There slight negative correlation regional (r≈-0.32, P < 0.001), South Asia exhibiting highest (3,398/100,000 people [95% UI: 2992 3860]). predicted increase, while expected decrease 2022 2035.Conclusion has increased past 30 continue increasing over next 15 years. heavier females, middle-aged,

Язык: Английский

Age-Related Macular Degeneration (AMD): Pathophysiology, Drug Targeting Approaches, and Recent Developments in Nanotherapeutics DOI Creative Commons
Mahendra Pratap Singh,

Riyakshi Negi,

Alka

и другие.

Medicina, Год журнала: 2024, Номер 60(10), С. 1647 - 1647

Опубликована: Окт. 8, 2024

The most prevalent reason for vision impairment in aging inhabitants is age-related macular degeneration (AMD), a posterior ocular disease with poor understanding of the anatomic, genetic, and pathophysiological progression disease. Recently, new insights exploring role atrophic changes retinal pigment epithelium, extracellular drusen deposits, lysosomal lipofuscin, various genes have been investigated AMD. Hence, this review explores incidence risk factors AMD, such as oxidative stress, inflammation, complement system, involvement bioactive lipids their angiogenesis. In addition to intravitreal anti-vascular endothelial growth factor (VEGF) therapy other therapeutic interventions oral kinase inhibitors, photodynamic, gene, antioxidant therapy, well benefits drawbacks AMD treatment options, strategic drug delivery methods, including routes focus on pharmacokinetics, are investigated. Further, recent advancements nanoformulations polymeric lipid nanocarriers, liposomes, etc., intended pros cons too summarized. Therefore, purpose give researchers an pathophysiology, emphasis angiogenesis, function lipids, options. Additionally, options that development system(s) via several can aid advancement choices.

Язык: Английский

Процитировано

5

Global, regional, and national burden and trends of air pollution-related neoplasms from 1990 to 2019: An observational trend study from the Global Burden of Disease Study 2019 DOI Creative Commons
Fang Ren, Gang Liu

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 285, С. 117068 - 117068

Опубликована: Сен. 24, 2024

Язык: Английский

Процитировано

3

Trend Analysis of Global, Regional, and National Burdens of Visual Impairment Due to Refraction Disorders from 1990 to 2021: Findings from the Global Burden of Disease Study 2021 DOI
Qing Zhou,

Ting Tang,

Yongbing Cai

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Abstract Purpose To estimate the global, regional, and national burden of vision impairment due to refraction disorders (RD) from 1990 2021 based on sex, age, Socio-demographic Index (SDI), predict future disease trends.Methods This retrospective demographic analysis utilized data Global Burden Disease (GBD) database. Prevalence, years lived with disability (YLDs), age-standardized prevalence rates (ASPR), YLDs (ASYR) RD were analyzed assess temporal, sex-specific trends. We calculated Average Annual Percentage Change (AAPC) determine changes in used Bayesian Age-Period-Cohort (BAPC) model forecast 2020 2035.Results ASPR ASYR declined 2021, AAPC is -3.76 (95% confidence interval [CI]: -4.20~-3.32) − 0.26 CI: -0.28~-0.25), respectively. In global was 159,765,917 uncertainty [UI]: 142,526,915 ~ 178,698,348). The slightly higher females than males, a among middle-aged elderly populations. There slight negative correlation regional (r≈-0.32, P < 0.001), South Asia exhibiting highest (3,398/100,000 people [95% UI: 2992 3860]). predicted increase, while expected decrease 2022 2035.Conclusion has increased past 30 continue increasing over next 15 years. heavier females, middle-aged,

Язык: Английский

Процитировано

0