Causal role of immune cells in bipolar disorder: a Mendelian randomization study DOI Creative Commons

M. Wang,

Shuo Wang,

Guoshan Yuan

и другие.

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Авг. 16, 2024

Background The understanding of the immunological mechanisms underlying bipolar disorder (BD) has enhanced in recent years due to extensive use high-density genetic markers for genotyping and advancements genome-wide association studies (GWAS). However, on relationship between immune cells risk BD remain limited, necessitating further investigation. Methods Bidirectional two-sample Mendelian Randomization (MR) analysis was employed investigate causal cell morphologies disorder. Immune traits were collected from a research cohort Sardinia, whereas GWAS summary statistics obtained Psychiatric Genomics Consortium. Sensitivity analyses conducted, combination MR-Egger MR-Presso used assess horizontal pleiotropy. Cochran’s Q test evaluate heterogeneity, results adjusted false discovery rate (FDR). Results study identified six phenotypes significantly associated with incidence ( P < 0.01). These include IgD- CD27- %lymphocyte, CD33br HLA DR+ CD14- AC, CD8 CD28+ CD45RA+ CD8br, CD14 CD14+ CD16+ monocyte, HVEM CD45RA- CD4+. After adjusting FDR 0.2, two remained statistically significant: IgD-CD27-% lymphocyte (OR=1.099, 95% CI: 1.051-1.149, = 3.51E-05, FDR=0.026) CD14-AC (OR=0.981, 0.971-0.991, 2.17E-04, FDR=0.079). In reverse MR analysis, impacted four monocytes 0.01), including CD64 CX3CR1 CD16-, CD16- monocyte. after applying correction (FDR 0.2), no significant observed. Conclusions This investigation reveals associations phenotypes, disorder, genetics, providing novel perspectives prospective therapeutic targets

Язык: Английский

Causal role of immune cells in bipolar disorder: a Mendelian randomization study DOI Creative Commons

M. Wang,

Shuo Wang,

Guoshan Yuan

и другие.

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Авг. 16, 2024

Background The understanding of the immunological mechanisms underlying bipolar disorder (BD) has enhanced in recent years due to extensive use high-density genetic markers for genotyping and advancements genome-wide association studies (GWAS). However, on relationship between immune cells risk BD remain limited, necessitating further investigation. Methods Bidirectional two-sample Mendelian Randomization (MR) analysis was employed investigate causal cell morphologies disorder. Immune traits were collected from a research cohort Sardinia, whereas GWAS summary statistics obtained Psychiatric Genomics Consortium. Sensitivity analyses conducted, combination MR-Egger MR-Presso used assess horizontal pleiotropy. Cochran’s Q test evaluate heterogeneity, results adjusted false discovery rate (FDR). Results study identified six phenotypes significantly associated with incidence ( P < 0.01). These include IgD- CD27- %lymphocyte, CD33br HLA DR+ CD14- AC, CD8 CD28+ CD45RA+ CD8br, CD14 CD14+ CD16+ monocyte, HVEM CD45RA- CD4+. After adjusting FDR 0.2, two remained statistically significant: IgD-CD27-% lymphocyte (OR=1.099, 95% CI: 1.051-1.149, = 3.51E-05, FDR=0.026) CD14-AC (OR=0.981, 0.971-0.991, 2.17E-04, FDR=0.079). In reverse MR analysis, impacted four monocytes 0.01), including CD64 CX3CR1 CD16-, CD16- monocyte. after applying correction (FDR 0.2), no significant observed. Conclusions This investigation reveals associations phenotypes, disorder, genetics, providing novel perspectives prospective therapeutic targets

Язык: Английский

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