The association of body roundness index and body mass index with frailty and all-cause mortality: a study from the population aged 40 and above in the United States

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 30, 2025

The relationship between body roundness index (BRI), a new obesity index, and frailty has not been established. This study aims to compare the associations of traditional mass (BMI) BRI with risk all-cause mortality. clinical data 15,157 participants over 40 years old from National Health Nutrition Examination Survey (NHANES) 2003 2018 were analyzed. Based on weighted logistic regression, COX regression restricted cubic spline, BMI odds mortality estimated. receiver operating characteristic curve (ROC) concordance used evaluate ability predict survival. Weighted showed that trend increasing increase (P for < 0.0001, respectively). After adjusting all confounding factors, association was stronger (OR: 1.20, 95% CI: 1.13–1.27, P 0.0001), slightly weaker 1.14, 1.08–1.21, 0.0001). ROC area under (AUC) predicting 0.628, while AUC 0.603, difference two significant (PDeLong 0.001). In addition, in survival analysis, U-shaped Piecewise based inflection point shows when 7.33, an reduces (HR: 0.85, 0.78–0.92, ≥ increases 1.19, 1.03–1.38, = 0.02); 33.57, 0.84, 0.78–0.91, 1.18, 1.04–1.34, 0.01). Moreover, time-dependent c-index frail people comparable BMI. American population old, both are independently positively associated frailty. than have individuals, abilities

Язык: Английский

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Associations of neutrophil/high-density lipoprotein cholesterol ratio with frailty and its mortality

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

Frailty is an increasingly important determinant in the field of health, and its identification has clinical significance critical care medicine. However, there are still a large number challenges quick accurate frailty. This study aims to evaluate value neutrophil/high-density lipoprotein cholesterol ratio (NHR) frailty long-term survival. Adult participants from seven cycles National Health Nutrition Examination Survey (NHANES) database were included. was assessed with 49-item Index (FI). Weighted logistic regression, restricted cubic spline (RCS), Cox regression used analyze association NHR In addition, subgroup interaction analyses also performed. A total 34,382 adult aged 47.6 on average included, 16,950 (48.8%) them males. After adjustment potential confounding variables, increase one standard deviation (SD) resulted incidence by 11% (OR: 1.11, 95% CI: 1.04-1.18, P = 0.002). RCS showed J-shaped between frailty, which robust all subgroups according analysis. survival analysis revealed that significantly positively associated all-cause (HR: 1.12, 1.07-1.17, < 0.0001), cardiocerebrovascular disease (CCD)-specific 1.21, 1.11-1.33, cancer-specific mortality risks 1.13, 1.07-1.19, 0.0001) frail individuals. American population, maintains relationship can help predict demonstrates may become effective predictor mortality.

Язык: Английский

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Predictive Value of Inflammation Markers for Frailty in Older Patients with CVD

Clinical Interventions in Aging, Год журнала: 2025, Номер Volume 20, С. 435 - 447

Опубликована: Апрель 1, 2025

Chronic inflammation plays a pivotal role in the development of frailty patients with cardiovascular diseases (CVD). Systemic inflammatory response index (SIRI) has been shown to reflect overall status. This study aimed investigate relationship between SIRI and older CVD, develop nomogram for predicting risk this population. A total 234 CVD were included. Inflammation markers derived from routine blood tests, status was assessed using FRAIL scale. Clinical laboratory characteristics compared or without frailty. Multivariate logistic regression employed identify significant variables inclusion nomogram. The performance nomogram, including its discrimination calibration, rigorously evaluated. 98 cases assigned group 136 non-frailty group. Patients generally younger, more likely have normal kidney function, better pressure control. Frail exhibited higher degree systemic non-frail (P < 0.05). Age, LDL-C identified as three independent factors potential patients. Therefore, we constructed clinical model based on age, SIRI. had considerable discriminative calibrating abilities. In summary, our demonstrated association elevated levels markers, particularly SIRI, an increased Furthermore, by integrating established predict CVD.

Язык: Английский

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Inflammatory parameters mediates the relationship between dietary index for gut microbiota and frailty in middle-aged and older adults in the United States: findings from a large-scale population-based study

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 16, 2025

Background Frailty is a prevalent geriatric syndrome marked by diminished physiological reserves and heightened vulnerability to stressors, leading adverse health outcomes imposing significant economic burdens on healthcare systems. Methods This study investigates the relationship between Dietary Index for Gut Microbiota (DI-GM) risk of frailty in middle-aged older adults, using data from National Health Nutrition Examination Survey (NHANES) collected 2007 2018. Weighted logistic regression, subgroup analysis, restricted cubic splines (RCS) were performed evaluate DI-GM risk. Additionally, mediation analysis was conducted investigate influence relevant inflammatory parameters complete blood count, including leukocyte neutrophil lymphocyte ratio (NLR), systemic response index (SIRI), elucidate how may onset progression frailty. Results In this cross-sectional 8,695 participants with mean age 65.56 years, 3,173 individuals classified as frail. After adjusting all covariates, inverse observed Quartile revealed that highest quartile had significantly lower odds compared those lowest (OR: 0.80, 95% CI: 0.65–0.99, p = 0.04). Trend analyses across models demonstrated consistent higher quartiles ( &lt; 0.0001 crude model; 0.001 Model 1; 0.04 2). Subgroup confirmed stability impact various subgroups. RCS showed decreased linearly increasing levels. Mediation indicated effects NLR, SIRI, proportions 5.7, 7.9, 4.4, 5.5%, respectively (all 0.001). Conclusion The levels are inversely associated frailty, part association mediated parameters.

Язык: Английский

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Correlation of nighttime fasting duration with cognitive decline in older adults: a cross-sectional study based on NHANES 2011-2014

Опубликована: Март 30, 2025

Background: Cognitive dysfunction is a significant health challenge in the global elderly population, and its prevalence associated with multiple factors, including modifiable lifestyle factors. The relationship between nighttime fasting duration, potential factor, cognitive function has yet to be thoroughly investigated. Objective: To investigate association duration function. Methods: This cross-sectional study was based on data from National Health Nutrition Examination Survey (NHANES) 2011 2014. Weighted linear regression utilized examine function, additional curve fitting inflection point analysis conducted further elucidate this Results: There negative (Learn: β = -1.2, 95% CI: -1.98, -0.43, P 0.006; Recall: -1.1, -2.11, -0.09, 0.036; Animal Fluency: -4.49, -7.26, -1.72, 0.004; Digit Symbol Substitution Test: -12.66, -19.30, -6.01, 0.002). Subgroup analyses showed that correlation prevalent most subgroups. Curve revealed scores, but did not identify point. Conclusions: Longer times may decline, either as continuous or categorical variable.

Язык: Английский

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Association of platelet-to-HDL cholesterol ratio with frailty and all-cause mortality

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Окт. 23, 2024

Frailty often requires intensive care, and the admission outcomes of frail patients are poor. However, owing to lack reliable diagnostic indicators, quickly identifying frailty is challenging. The present study aimed explore associations platelet/high-density lipoprotein cholesterol ratio (PHR; a novel inflammatory indicator) with all-cause mortality. analyzed data from National Health Nutrition Examination Survey (NHANES) 2005 2018. was assessed on basis 49-item Index. PHR long-term survival prognosis were explored through weighted logistic regression, restricted cubic spline (RCS), Cox adjustments for demographic factors, lifestyle, blood lipids, medication history, complications. In addition, subgroup interaction analyses conducted. Finally, several sensitivity performed. A total 15,615 adult participants included, 7,928 women (53.63%) an average age 60.76 years. After fully adjusting confounding variables, prevalence in highest quartile group significantly greater than that lowest (OR: 1.23, 95% CI: 1.04–1.47; P = 0.02). RCS showed inflection point 166.7. Before after point, negatively associated 0.88, 0.80–0.97, 0.01) positively 1.10, 1.02–1.19, frailty, respectively. Subgroup analysis suggested association between stronger men. 5,544 included analysis. revealed mortality risk U-shaped manner, 240.4. decreased (HR: 0.89, 0.81–0.97, increased 1.08, 1.02–1.14, 0.01), suggests there J-shaped population United States women. has relationship patients.

Язык: Английский

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Letter to the editor—Association between ethylene oxide levels and depressive symptoms: A cross-sectional study based on NHANES 2013–2018 database

Journal of Affective Disorders, Год журнала: 2024, Номер 360, С. 114 - 115

Опубликована: Май 27, 2024

Язык: Английский

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