The effects of low-carbohydrate diet on glucose and lipid metabolism in overweight or obese patients with T2DM: a meta-analysis of randomized controlled trials DOI Creative Commons

Wende Tian,

Suyan Cao, Y. Guan

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 6, 2025

The dual burden of Type 2 Diabetes Mellitus (T2DM) and obesity is a critical public health issue. Low-carbohydrate diets have emerged as potential intervention, yet clinical evidence remains inconclusive. This meta-analysis assesses the impact low-carbohydrate on metabolic profiles in overweight or obese T2DM patients, aiming to guide practice. A systematic review identified randomized trials (RCTs) comparing control patients from PubMed, Embase, Cochrane Library databases up April 2023. Seventeen RCTs, encompassing 1,197 participants, demonstrated that significantly improved HbA1c levels fasting plasma glucose (mean difference [MD] = -0.36, 95% CI -0.44 -0.29, p < 0.00001; MD -10.71, -14.39 -7.03, 0.00001). They also reduced triglycerides increased HDL cholesterol (MD -19.91, -28.83 -10.99, 2.49, 1.07-3.91, 0.0006), without affecting LDL total cholesterol. Weight loss, BMI, lower diastolic blood pressure, decreased waist circumference were additional benefits. may enhance glycemic lipid warranting consideration management. However, variability diet definitions methodologies underscores necessity for further research standardize dietary guidelines evaluate long-term effects.

Язык: Английский

The effects of low-carbohydrate diet on glucose and lipid metabolism in overweight or obese patients with T2DM: a meta-analysis of randomized controlled trials DOI Creative Commons

Wende Tian,

Suyan Cao, Y. Guan

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 6, 2025

The dual burden of Type 2 Diabetes Mellitus (T2DM) and obesity is a critical public health issue. Low-carbohydrate diets have emerged as potential intervention, yet clinical evidence remains inconclusive. This meta-analysis assesses the impact low-carbohydrate on metabolic profiles in overweight or obese T2DM patients, aiming to guide practice. A systematic review identified randomized trials (RCTs) comparing control patients from PubMed, Embase, Cochrane Library databases up April 2023. Seventeen RCTs, encompassing 1,197 participants, demonstrated that significantly improved HbA1c levels fasting plasma glucose (mean difference [MD] = -0.36, 95% CI -0.44 -0.29, p < 0.00001; MD -10.71, -14.39 -7.03, 0.00001). They also reduced triglycerides increased HDL cholesterol (MD -19.91, -28.83 -10.99, 2.49, 1.07-3.91, 0.0006), without affecting LDL total cholesterol. Weight loss, BMI, lower diastolic blood pressure, decreased waist circumference were additional benefits. may enhance glycemic lipid warranting consideration management. However, variability diet definitions methodologies underscores necessity for further research standardize dietary guidelines evaluate long-term effects.

Язык: Английский

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